Thursday, November 21, 2024 11/21/2024

Mechanisms of chromatin and transcriptional regulation

Award Number: R35GM126900
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Our long-term goal has been to reveal the molecular mechanisms of histone-modifying enzymes, histone chaperones and other transcriptional regulators that control genome function. Many of the proteins and their modifications we study are dysregulated in human disease, including cancer. Despite considerable progress by our lab and others, crucial knowledge gaps remain in our fundamental understanding of chromatin regulation. With the renewal of this MIRA award, we will continue our studies into the function of chromatin regulators and address three of the foremost fundamental questions in chromatin biology: 1) How do histone-modifying enzymes and chaperones contribute to chromatin organization and gene transcription? 2) How do more recently discovered histone PTMs and reader domains contribute to gene transcription? 3) What are the rules by which histone readers engage nucleosomes and how do these binding events regulate downstream events in chromatin? For each question, we highlight several examples of the types of studies we are pursuing and describe how they will advance the field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	7	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $673,380 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	003	7	5/29/2024	SUPPLEMENT FOR EXPANSION	$86,867
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	7	4/10/2024	NON-COMPETING CONTINUATION	$527,862
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	004	7	6/26/2024	NON-COMPETING CONTINUATION	$58,651
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	6	3/18/2024	COMPETING CONTINUATION	$43,505
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	5	3/18/2024	SUPPLEMENT FOR EXPANSION	-$43,505
														Subtotal = $673,380

Issue Date FY: 2023 ( Subtotal = $586,513 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	6	3/30/2023	COMPETING CONTINUATION	$586,513
														Subtotal = $586,513

Issue Date FY: 2022 ( Subtotal = $651,718 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	5	7/25/2022	SUPPLEMENT FOR EXPANSION	$89,938
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	4/20/2022	NON-COMPETING CONTINUATION	$561,780
														Subtotal = $651,718

Issue Date FY: 2021 ( Subtotal = $561,780 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	4	4/21/2021	NON-COMPETING CONTINUATION	$561,780
														Subtotal = $561,780

Issue Date FY: 2020 ( Subtotal = $584,921 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	3	8/26/2020	SUPPLEMENT FOR EXPANSION	$23,141
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	3	3/31/2020	NON-COMPETING CONTINUATION	$561,780
														Subtotal = $584,921

Issue Date FY: 2019 ( Subtotal = $631,403 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	2	6/18/2019	SUPPLEMENT FOR EXPANSION	$69,623
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	2	4/10/2019	NON-COMPETING CONTINUATION	$561,780
														Subtotal = $631,403

Issue Date FY: 2018 ( Subtotal = $638,875 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	1	3/2/2018	NEW	$638,875
														Subtotal = $638,875

Grand Total All Awards = $4,328,590

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Mechanisms of chromatin and transcriptional regulation

Award Number: R35GM126900

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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