Thursday, November 21, 2024 11/21/2024

Renewal: MIRA: Epigenetic regulation of genome integrity, environmental interaction, and inheritance

Award Number: R35GM124806
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Although the genome is a blueprint for making an organism, the epigenome (modification on the genome without DNA sequence change) governs the functional outcome of genes and ultimately shapes the organism. Epigenetic modification is a conserved and important gene regulatory mechanism and plays quintessential roles in genome integrity, development, environmental responses, and diseases. Despite the large number of correlative studies describing the altered modification patterns in abnormal developmental and pathological tissues, whether they are a cause or a consequence is poorly understood. This proposal dissects the molecular mechanism of epigenetic regulation and functional consequences of epigenome perturbation under developmental and physiological conditions. Specifically, we investigate i) how epigenome reprogramming in response to environmental cues might lead to stress adaptation; ii) how an epigenetic switch regulates developmental phase transition; and iii) how epigenetic modification safeguards the genome integrity. We will further dissect the causal roles of epigenetic marks on gene expression and develop an innovative CRISPR/Cas9-mediated cis- engineering system for epigenome editing. Our approach is highly interdisciplinary making use of the powerful Arabidopsis genetic system, high-throughput proteomics and genomics, live-cell imaging techniques, biochemical and structural tools to tackle mechanistic problems from genome-wide scale to atomic resolution. As we probe basic principles governing epigenetic regulation that are conserved across eukaryotes, the mechanistic knowledge and epigenome technologies acquired from our pioneering Arabidopsis studies will help accelerate progress in deciphering the relevant mechanisms in human. Such knowledge will lead to the development of innovative tools to correct aberrant epigenetic modifications and ultimately enable new applications for medicine and human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	000	8	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $427,625 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	8	7/11/2024	NON-COMPETING CONTINUATION	$427,625
														Subtotal = $427,625

Issue Date FY: 2023 ( Subtotal = $648,964 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	003	7	9/18/2023	SUPPLEMENT FOR EXPANSION	$221,339
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	002	7	7/7/2023	NON-COMPETING CONTINUATION	$427,625
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	001	6	11/16/2022	COMPETING CONTINUATION	$130,410
2023	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	5	11/16/2022	NON-COMPETING CONTINUATION	-$130,410
														Subtotal = $648,964

Issue Date FY: 2022 ( Subtotal = $432,667 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	001	6	7/26/2022	COMPETING CONTINUATION	$432,667
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	5	7/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $432,667

Issue Date FY: 2021 ( Subtotal = $376,140 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	5	6/30/2021	NON-COMPETING CONTINUATION	$376,140
														Subtotal = $376,140

Issue Date FY: 2020 ( Subtotal = $376,140 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	4	7/23/2020	NON-COMPETING CONTINUATION	$376,140
														Subtotal = $376,140

Issue Date FY: 2019 ( Subtotal = $376,140 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	3	7/16/2019	NON-COMPETING CONTINUATION	$376,140
														Subtotal = $376,140

Issue Date FY: 2018 ( Subtotal = $376,140 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	2	6/29/2018	NON-COMPETING CONTINUATION	$376,140
														Subtotal = $376,140

Issue Date FY: 2017 ( Subtotal = $376,140 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	1	7/24/2017	NEW	$376,140
														Subtotal = $376,140

Grand Total All Awards = $3,389,956

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Renewal: MIRA: Epigenetic regulation of genome integrity, environmental interaction, and inheritance

Award Number: R35GM124806

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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