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Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications

Award Number: R35GM119770
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2016
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications - PROJECT SUMMARY/ABSTRACT The immune system is arguably the second most complex human system after the brain. Its proper response to foreign stimuli is governed by network-like interactions among various types of cells and cytokines as their communication mediators. The complexity at the inter-cellular level of the immune system is further exacerbated by the similarly complex biological and biochemical networks within each cell (metabolism, gene regulation, etc.) responsible for the dynamics and decision-making at the single-cell level. Such multiscale complexity makes it incredibly challenging to understand the complete etiology and pathology of immune-system-related diseases. My research program aims to identify how the immune system can be rewired en masse to elicit higher-order decision-making while still enabling the system to remain otherwise “healthy.” To this end, my research program is leveraging a highly interdisciplinary research team (computational and experimental immunologists, software engineers, and education researchers) and collaborators to build a Virtual Immune System -- a multi-scale, multi-approach computational framework to understand better the complex dynamical nature of the immune system, identify more accurate multi-dimensional biomarkers, and identify safe and effective treatments within a reasonable time and cost. In the next five years, in addition to expanding the Virtual Immune system, my program will continue to develop methods and technologies for data-driven model construction, visualization, computation, real-time simulations, and reproducibility to advance multi-scale modeling of the immune system and beyond. We will continue to decipher the dynamics of the immune system under various pathologies and the re-programmability of CD4+ T cells under the milieu of their microenvironments. My laboratory will continue to iteratively predict, validate, and refine predictions generated using the systems approaches and technologies. To do this, we will generate our multi-omics data to more precisely validate immune system behaviors and apply our findings to refine the computational approaches directly. My team will continue to build collaborations and deepen our existing relationships, including with translational partners to advance the impact of our systems work on drug discovery, the international team modeling COVID-19, and with virologists and immunologists to further validate our computational predictions experimentally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $371,250 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	9	8/5/2025	NON-COMPETING CONTINUATION	$37,125
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	9	11/19/2024	NON-COMPETING CONTINUATION	$334,125
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	8	11/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $371,250

Issue Date FY: 2024 ( Subtotal = $371,250 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	8	6/19/2024	NON-COMPETING CONTINUATION	$37,125
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	8	12/13/2023	NON-COMPETING CONTINUATION	$334,125
														Subtotal = $371,250

Issue Date FY: 2023 ( Subtotal = $618,605 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	7	12/6/2022	NON-COMPETING CONTINUATION	$334,125
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	7	2/21/2023	NON-COMPETING CONTINUATION	$37,125
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	7	7/12/2023	SUPPLEMENT FOR EXPANSION	$247,355
														Subtotal = $618,605

Issue Date FY: 2022 ( Subtotal = $594,000 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	004	6	8/30/2022	SUPPLEMENT FOR EXPANSION	$222,750
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	6	12/23/2021	COMPETING CONTINUATION	$371,250
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	003	6	7/26/2022	COMPETING CONTINUATION	$29,613
2022	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	5	12/15/2021	NON-COMPETING CONTINUATION	$0
2022	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	5	7/26/2022	NON-COMPETING CONTINUATION	-$29,613
														Subtotal = $594,000

Issue Date FY: 2020 ( Subtotal = $355,364 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	5	6/18/2020	NON-COMPETING CONTINUATION	$355,364
														Subtotal = $355,364

Issue Date FY: 2019 ( Subtotal = $600,364 )
2019	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	4	8/27/2019	SUPPLEMENT FOR EXPANSION	$245,000
2019	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	6/24/2019	NON-COMPETING CONTINUATION	$355,364
														Subtotal = $600,364

Issue Date FY: 2018 ( Subtotal = $356,295 )
2018	2018	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	3	7/2/2018	NON-COMPETING CONTINUATION	$356,295
														Subtotal = $356,295

Issue Date FY: 2017 ( Subtotal = $356,699 )
2017	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	2	6/15/2017	NON-COMPETING CONTINUATION	$356,699
														Subtotal = $356,699

Issue Date FY: 2016 ( Subtotal = $356,845 )
2016	2016	UNIVERSITY OF NEBRASKA LINCOLN	303 ADMINISTRATION BUILDING	LINCOLN	NE	68588	LANCASTER	USA	Biomedical Research and Research Training	000	1	8/29/2016	NEW	$356,845
														Subtotal = $356,845

Grand Total All Awards = $3,980,672

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Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications

Award Number: R35GM119770

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2016

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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