Friday, March 14, 2025 3/14/2025

Membrane Protein Effectors of Pathogen Interactions With Host

Award Number: R35GM118186
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

SUMMARY Membrane protein effectors of pathogen interactions with host. The goal of this project is to develop a framework for understanding the way in which the human host defenses interact with microbial pathogens and age-related stressors. Many pathogens have evolved strategies to evade innate immunity by recruiting complement regulatory factors onto the microbial cell surface. Moreover, the ectopic deposits that form in age- related macular degeneration (AMD) and Alzheimer's disease (AD) are also rich in blood proteins involved in innate immunity. Despite the biomedical importance of these processes, mechanistic knowledge is limited. This research project is designed to address this knowledge gap. We focus on determining the structural basis for two central interactions of human blood proteins involved in immunity, hemostasis and cell adhesion and cell migration: (1) interactions with outer membrane proteins from the bacterial pathogen Yersinia pestis that are important for pathogenesis, and (2) interactions with lipids and biominerals that are relevant to the formation of pathological deposits associated with AMD and AD. Proteins in these highly heterogenous environments play central roles in human health but are highly under-represented in the scientific knowledge base. We aim to bridge this fundamental knowledge gap. Addressing these problems is important for advancing comprehensive knowledge of the disease process and for developing diagnostic, preventive, and therapeutic approaches. The research strategy is multidisciplinary. It relies significantly on structural biology techniques, particularly solution NMR and solid-state NMR. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	000	10	11/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $773,075 )
2024	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	000	10	5/8/2024	NON-COMPETING CONTINUATION	$647,400
2024	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	001	10	9/6/2024	SUPPLEMENT FOR EXPANSION	$125,675
														Subtotal = $773,075

Issue Date FY: 2023 ( Subtotal = $534,860 )
2023	2023	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	005	9	9/13/2023	NON-COMPETING CONTINUATION	$647,400
2023	2022	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	004	8	7/20/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$98,564
2023	2022	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Biomedical Research and Research Training	002	8	6/22/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$442,260
2023	2022	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	003	7	7/20/2023	NON-COMPETING CONTINUATION	-$98,564
2023	2022	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	7	6/21/2023	NON-COMPETING CONTINUATION	-$554,800
2023	2020	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	5	11/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $534,860

Issue Date FY: 2022 ( Subtotal = $809,250 )
2022	2022	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	7	5/27/2022	NON-COMPETING CONTINUATION	$809,250
														Subtotal = $809,250

Issue Date FY: 2021 ( Subtotal = $809,250 )
2021	2021	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	002	6	9/19/2021	COMPETING CONTINUATION	$250,000
2021	2021	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	6	5/12/2021	COMPETING CONTINUATION	$809,250
2021	2020	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	5	9/19/2021	NON-COMPETING CONTINUATION	-$250,000
														Subtotal = $809,250

Issue Date FY: 2020 ( Subtotal = $752,107 )
2020	2020	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	5	5/22/2020	NON-COMPETING CONTINUATION	$752,107
														Subtotal = $752,107

Issue Date FY: 2019 ( Subtotal = $752,107 )
2019	2019	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	4	5/28/2019	NON-COMPETING CONTINUATION	$752,107
														Subtotal = $752,107

Issue Date FY: 2018 ( Subtotal = $1,127,999 )
2018	2018	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	3	5/15/2018	NON-COMPETING CONTINUATION	$877,999
2018	2018	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	3	9/17/2018	SUPPLEMENT FOR EXPANSION	$250,000
														Subtotal = $1,127,999

Issue Date FY: 2017 ( Subtotal = $877,999 )
2017	2017	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	2	6/27/2017	SUPPLEMENT FOR EXPANSION	$125,892
2017	2017	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	10901 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	2	6/12/2017	NON-COMPETING CONTINUATION	$752,107
														Subtotal = $877,999

Issue Date FY: 2016 ( Subtotal = $752,107 )
2016	2016	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE	10901 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	1	5/20/2016	NEW	$752,107
														Subtotal = $752,107

Grand Total All Awards = $7,188,754

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Membrane Protein Effectors of Pathogen Interactions With Host

Award Number: R35GM118186

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer