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 | Issue Date FY: 2024 ( Subtotal = $52,781,486 ) (Continued on the next page) |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 001 | 5 | NIH | 6/10/2024 | $92,970 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 000 | 5 | NIH | 1/4/2024 | $836,735 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA286431 | Discovery of Potent Selective Inhibitors of the Histone Methyltransferase SUV39H1 for the Treatment of Cancer | 000 | 1 | NIH | 7/1/2024 | $809,234 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG072468 | Microglial heparan sulfate in the modulation of APOE function and neurodegeneration | 001 | 3 | NIH | 5/1/2024 | $58,096 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG072468 | Microglial heparan sulfate in the modulation of APOE function and neurodegeneration | 000 | 3 | NIH | 11/29/2023 | $522,864 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071694 | Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies | 001 | 3 | NIH | 5/10/2024 | $87,818 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071694 | Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies | 000 | 3 | NIH | 11/17/2023 | $790,358 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA267103 | Targeting the FBXO44/SUV39H1 Pathway in Cancer | 001 | 3 | NIH | 4/17/2024 | $22,304 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA267103 | Targeting the FBXO44/SUV39H1 Pathway in Cancer | 000 | 3 | NIH | 11/30/2023 | $401,456 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG086914 | Discovery and optimization of ApoE4 correctors for the treatment of Alzheimer's Disease | 000 | 1 | NIH | 7/11/2024 | $919,106 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG083373 | Hormetic regulation of autophagy in aging | 000 | 1 | NIH | 7/1/2024 | $586,599 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AR056712 | Pathogenic Alterations of the 3D Epigenetic Landscape in Dystrophin-Deficient Skeletal Muscles and Reversal by Dystrophin Re-Expression | 000 | 13 | NIH | 6/3/2024 | $636,717 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R33HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 3 | NIH | 4/26/2024 | $596,061 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | RF1AG087011 | Fragment-based discovery of STEP modulators in Alzheimer's disease | 000 | 1 | NIH | 5/15/2024 | $2,835,382 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | S10OD036254 | Beckman Coulter Biomek i7 Hybrid automated workstation | 000 | 1 | NIH | 3/26/2024 | $594,187 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AA030888 | Optimization of Drug-like Properties of CRFBP-CRF2 Negative Allosteric Modulators for Alcohol Use Disorder | 001 | 2 | NIH | 8/6/2024 | $800,043 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U01DA057847 | Safety/Toxicology, ADME and CMC Activities to Support the Assessment of the mGlu2 PAM SBP-9330 in a Phase 2 Clinical Study in Smokers | 002 | 2 | NIH | 7/11/2024 | $3,331,239 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R56AG080525 | Discovery and development of apoE4 correctors for the treatment of Alzheimer's disease | 000 | 2 | NIH | 6/7/2024 | $881,443 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01NS132780 | Investigation of ecDNA as a driver of intratumoral heterogeneity and treatment resistance in high-risk medulloblastoma | 000 | 2 | NIH | 8/1/2024 | $617,669 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 001 | 4 | NIH | 4/10/2024 | $17,412 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 000 | 4 | NIH | 3/1/2024 | $223,848 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK133930 | Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases | 002 | 2 | NIH | 8/27/2024 | $0 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK133930 | Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases | 001 | 2 | NIH | 8/23/2024 | $480,000 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R50CA283813 | Development and Implementation of Advanced Technologies for Cancer Metabolism Research | 000 | 2 | NIH | 8/12/2024 | $142,032 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA276193 | Discovery of Novel Inhibitors Targeting trans-Golgi Network Acidification in Pancreatic Cancer | 001 | 2 | NIH | 4/17/2024 | $32,253 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA276193 | Discovery of Novel Inhibitors Targeting trans-Golgi Network Acidification in Pancreatic Cancer | 000 | 2 | NIH | 2/28/2024 | $580,572 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL158677 | Regulation of Blood Glycoproteins by Lectin Receptors in Health and Disease | 000 | 2 | NIH | 3/29/2024 | $487,500 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK137061 | Dissecting the Intracellular and Extracellular Role of TREM2 in the Pathogenesis of Non-Alcoholic Steatohepatitis. | 001 | 2 | NIH | 8/23/2024 | $661,236 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK132689 | Improving Proinsulin Folding to Ameliorate Type II Diabetes | 000 | 2 | NIH | 5/7/2024 | $730,079 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01GM143583 | Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control | 000 | 3 | NIH | 6/27/2024 | $555,975 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U54AG079758 | Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics | 001 | 3 | NIH | 7/8/2024 | $2,690,250 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266973 | GCDH Addiction in Melanoma | 000 | 3 | NIH | 6/4/2024 | $699,580 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 000 | 3 | NIH | 3/26/2024 | $401,456 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 001 | 3 | NIH | 4/16/2024 | $22,304 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35GM147487 | Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes | 000 | 3 | NIH | 7/23/2024 | $487,500 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK134099 | Augmented Notch signaling as a therapeutic approach for Alagille Syndrome | 000 | 3 | NIH | 5/14/2024 | $411,840 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA262794 | EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction | 001 | 3 | NIH | 9/10/2024 | $111,834 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA262794 | EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction | 000 | 3 | NIH | 5/10/2024 | $508,287 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA287114 | Rewiring T cell exhaustion with immune checkpoint blockade therapy | 000 | 1 | NIH | 8/7/2024 | $674,996 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266828 | Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer | 001 | 3 | NIH | 4/17/2024 | $30,377 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266828 | Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer | 000 | 3 | NIH | 11/13/2023 | $546,821 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01EY031745 | Retinoic acid target genes and transcriptional mechanisms during eye development | 000 | 4 | NIH | 5/22/2024 | $390,000 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL153645 | Discovery of small molecule regulators of atrial cardiomyocyte action potential duration to restore normal cardiac rhythm in atrial fibrillation | 000 | 4 | NIH | 5/31/2024 | $487,500 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA254806 | Regulation and Function of Stromal Macropinocytosis in Pancreatic Ductal Adenocarcinoma | 000 | 4 | NIH | 9/5/2024 | $556,513 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071861 | Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions | 001 | 4 | NIH | 7/5/2024 | $42,849 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071861 | Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions | 000 | 4 | NIH | 2/2/2024 | $385,652 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071465 | Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brain | 000 | 5 | NIH | 5/16/2024 | $924,514 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071464 | Defining chromostasis - a candidate regulator of healthy aging and longevity | 000 | 5 | NIH | 5/17/2024 | $514,488 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI158552 | Overriding the Immune Evasion Tactics of Coronavirus | 001 | 4 | NIH | 7/30/2024 | $601,563 |
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