| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2025 ( Subtotal = $7,941,822 ) |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI151371 | Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease | 000 | 5 | NIH | 2/20/2025 | $472,875 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00AG068303 | Epigenetic Reprogramming to Counteract Neuronal Aging and Degeneration | 000 | 4 | NIH | 2/14/2025 | $224,100 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG085498 | Novel Neuroprotective Roles for the Alzheimer's Disease Risk Gene SORLA in Tau Pathology and Pathogenesis | 000 | 2 | NIH | 11/25/2024 | $777,415 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA267103 | Targeting the FBXO44/SUV39H1 Pathway in Cancer | 000 | 4 | NIH | 11/13/2024 | $401,456 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071694 | Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies | 000 | 4 | NIH | 11/15/2024 | $787,444 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI167977 | Comparative resistomics of Gram-negative bacterial pathogens | 000 | 4 | NIH | 12/23/2024 | $733,500 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL158677 | Regulation of Blood Glycoproteins by Lectin Receptors in Health and Disease | 000 | 3 | NIH | 4/1/2025 | $487,500 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | RF1AG087011 | Fragment-Based Discovery of STEP Modulators in Alzheimer's Disease Administrative Supplement | 000 | 1 | NIH | 1/13/2025 | $111,976 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK132689 | Improving Proinsulin Folding to Ameliorate Type II Diabetes | 000 | 3 | NIH | 4/29/2025 | $760,498 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266828 | Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer | 000 | 4 | NIH | 11/6/2024 | $485,003 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA262746 | Molecular Pathogenesis of AF10-Rearranged Leukemias | 000 | 4 | NIH | 3/26/2025 | $404,348 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071861 | Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions | 000 | 5 | NIH | 3/7/2025 | $385,652 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | F31CA298202 | PIKfyve regulates pH homeostasis and tumor growth in pancreatic cancer | 000 | 1 | NIH | 5/6/2025 | $40,246 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA301721 | Screening for Inhibitors of the Chromatin Reader SGF29 | 000 | 1 | NIH | 4/8/2025 | $751,429 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA301721 | Screening for Inhibitors of the Chromatin Reader SGF29 | 001 | 1 | NIH | 4/22/2025 | $17,008 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01GM131374 | Eph Receptor Heterointeractions in Signaling | 000 | 6 | NIH | 12/24/2024 | $27,399 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG072468 | Microglial heparan sulfate in the modulation of APOE function and neurodegeneration | 000 | 4 | NIH | 11/22/2024 | $522,864 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21CA293150 | Immune Checkpoint Blockade Targeting the Novel PSGL-1/VISTA Axis for Pancreatic Cancer | 000 | 1 | NIH | 3/10/2025 | $268,345 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 000 | 5 | NIH | 3/14/2025 | $223,848 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA276193 | Discovery of Novel Inhibitors Targeting trans-Golgi Network Acidification in Pancreatic Cancer | 000 | 3 | NIH | 2/12/2025 | $580,798 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 000 | 4 | NIH | 3/25/2025 | $401,456 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK133930 | Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases | 001 | 2 | NIH | 3/18/2025 | $310,166 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U54AG079758 | Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics | 000 | 3 | NIH | 2/14/2025 | $0 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35CA283706 | Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance | 002 | 1 | NIH | 4/22/2025 | -$142,750 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35CA283706 | Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance | 000 | 1 | NIH | 4/2/2025 | -$826,436 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U01DA057847 | Safety/Toxicology, ADME and CMC Activities to Support the Assessment of the mGlu2 PAM SBP-9330 in a Phase 2 Clinical Study in Smokers | 000 | 2 | NIH | 3/24/2025 | $0 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI148668 | Characterizing the nuclear pore complex-T cell receptor connection | 000 | 5 | NIH | 4/23/2025 | $0 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | UH3DA050316 | Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders | 000 | 3 | NIH | 1/13/2025 | $0 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK137061 | Dissecting the Intracellular and Extracellular Role of TREM2 in the Pathogenesis of Non-Alcoholic Steatohepatitis. | 001 | 2 | NIH | 3/18/2025 | $181,353 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R33HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 3 | NIH | 10/9/2024 | $47,465 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AR076247 | Denervation activated super-enhancers of pathogenic IL6-STAT3 feedforward loop in FAPs | 000 | 5 | NIH | 3/20/2025 | $0 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG062190 | "A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways" | 000 | 5 | NIH | 2/4/2025 | -$2,407 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG075446 | Epigenetic drift of the Aging Heart in Drosophila | 000 | 2 | NIH | 2/4/2025 | $0 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | F99CA274682 | The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly | 000 | 2 | NIH | 1/23/2025 | -$11,170 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R37CA270362 | Regulation of the tumor microenvironment by DNA damage repair proteins | 000 | 1 | NIH | 2/21/2025 | -$170,016 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG062617 | Discovery of Selective Inhibitors for the EphA4 Kinase | 000 | 4 | NIH | 4/25/2025 | $0 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | F32HL156607 | Identifying novel networks of candidate Atrial Fibrillation genes in the Drosophila cardiac aging model | 000 | 3 | NIH | 1/23/2025 | $0 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R61HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 2 | NIH | 10/9/2024 | -$47,465 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG083782 | Testing the utility of miBioAge as a personalized aging biomarker | 000 | 1 | NIH | 4/16/2025 | -$84,956 |
| | 2025 | 2022 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R56AG073965 | New Down syndrome brain organization revealed by single-cell genomics | 000 | 2 | NIH | 11/12/2024 | -$14,012 |
| | 2025 | 2022 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | T32CA211036 | Cancer Targets and Drug Discovery | 000 | 5 | NIH | 11/6/2024 | -$92,537 |
| | 2025 | 2022 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 000 | 11 | NIH | 1/13/2025 | -$70,574 |
| | 2025 | 2021 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R56AR067731 | Factors Regulating Development of Appendicular Skeletal Progenitors | 000 | 6 | NIH | 12/16/2024 | $0 |
|
| Issue Date FY: 2024 ( Subtotal = $52,781,486 ) (Continued on the next page) |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA272433 | Macropinocytosis Inhibition as a Glutamine Mimetic Sensitization Strategy in Pancreatic Cancer | 000 | 1 | NIH | 7/17/2024 | $561,077 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00AG068303 | Epigenetic Reprogramming to Counteract Neuronal Aging and Degeneration | 000 | 3 | NIH | 1/26/2024 | $248,999 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35CA283706 | Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance | 000 | 1 | NIH | 7/25/2024 | $1,170,000 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 001 | 5 | NIH | 6/10/2024 | $92,970 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 000 | 5 | NIH | 1/4/2024 | $836,735 |
|
