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 | Issue Date FY: 2025 ( Subtotal = $1,567,354 ) |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA267103 | Targeting the FBXO44/SUV39H1 Pathway in Cancer | 000 | 4 | NIH | 11/13/2024 | $401,456 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071694 | Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies | 000 | 4 | NIH | 11/15/2024 | $787,444 |
| | 2025 | 2025 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266828 | Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer | 000 | 4 | NIH | 11/6/2024 | $485,003 |
| | 2025 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R33HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 3 | NIH | 10/9/2024 | $47,465 |
| | 2025 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R61HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 2 | NIH | 10/9/2024 | -$47,465 |
| | 2025 | 2022 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R56AG073965 | New Down syndrome brain organization revealed by single-cell genomics | 000 | 2 | NIH | 11/12/2024 | -$14,012 |
| | 2025 | 2022 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | T32CA211036 | Cancer Targets and Drug Discovery | 000 | 5 | NIH | 11/6/2024 | -$92,537 |
|
| Issue Date FY: 2024 ( Subtotal = $52,781,486 ) (Continued on the next page) |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 001 | 4 | NIH | 4/10/2024 | $17,412 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 000 | 4 | NIH | 3/1/2024 | $223,848 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P01HL131474 | Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis | 000 | 9 | NIH | 6/7/2024 | $2,622,490 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA287114 | Rewiring T cell exhaustion with immune checkpoint blockade therapy | 000 | 1 | NIH | 8/7/2024 | $674,996 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01GM131374 | Eph Receptor Heterointeractions in Signaling | 002 | 6 | NIH | 5/14/2024 | $484,417 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK099551 | New Congenital Disorders of Glycosylation: Therapy and Models | 001 | 10 | NIH | 9/5/2024 | $809,566 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG083373 | Hormetic regulation of autophagy in aging | 000 | 1 | NIH | 7/1/2024 | $586,599 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071464 | Defining chromostasis - a candidate regulator of healthy aging and longevity | 000 | 5 | NIH | 5/17/2024 | $514,488 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266973 | GCDH Addiction in Melanoma | 000 | 3 | NIH | 6/4/2024 | $699,580 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 000 | 3 | NIH | 3/26/2024 | $401,456 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA262794 | EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction | 000 | 3 | NIH | 5/10/2024 | $508,287 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | S10OD036254 | Beckman Coulter Biomek i7 Hybrid automated workstation | 000 | 1 | NIH | 3/26/2024 | $594,187 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 001 | 3 | NIH | 4/16/2024 | $22,304 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA262794 | EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction | 001 | 3 | NIH | 9/10/2024 | $111,834 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35CA283706 | Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance | 000 | 1 | NIH | 7/25/2024 | $1,170,000 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA286431 | Discovery of Potent Selective Inhibitors of the Histone Methyltransferase SUV39H1 for the Treatment of Cancer | 000 | 1 | NIH | 7/1/2024 | $809,234 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK133930 | Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases | 002 | 2 | NIH | 8/27/2024 | $0 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI148668 | Characterizing the nuclear pore complex-T cell receptor connection | 000 | 5 | NIH | 11/15/2023 | $588,229 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK133930 | Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases | 001 | 2 | NIH | 8/23/2024 | $480,000 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI148668 | Characterizing the nuclear pore complex-T cell receptor connection | 001 | 5 | NIH | 5/16/2024 | $65,358 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P30CA030199 | Cancer Center Support Grant (CCSG) | 001 | 43 | NIH | 9/24/2024 | $0 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P01CA281819 | Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC) | 000 | 1 | NIH | 9/9/2024 | $2,397,277 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA254806 | Regulation and Function of Stromal Macropinocytosis in Pancreatic Ductal Adenocarcinoma | 000 | 4 | NIH | 9/5/2024 | $556,513 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01GM143583 | Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control | 000 | 3 | NIH | 6/27/2024 | $555,975 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R50CA283813 | Development and Implementation of Advanced Technologies for Cancer Metabolism Research | 000 | 2 | NIH | 8/12/2024 | $142,032 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | UH3DA050316 | Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders | 000 | 3 | NIH | 7/19/2024 | $1,348,795 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA272433 | Macropinocytosis Inhibition as a Glutamine Mimetic Sensitization Strategy in Pancreatic Cancer | 000 | 1 | NIH | 7/17/2024 | $561,077 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK137061 | Dissecting the Intracellular and Extracellular Role of TREM2 in the Pathogenesis of Non-Alcoholic Steatohepatitis. | 001 | 2 | NIH | 8/23/2024 | $661,236 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01MH123826 | A Pharmacochaperone-based strategy for identifying chemical probes of brain-derived orphan GPCRs | 001 | 5 | NIH | 8/15/2024 | $78,508 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AA030888 | Optimization of Drug-like Properties of CRFBP-CRF2 Negative Allosteric Modulators for Alcohol Use Disorder | 001 | 2 | NIH | 8/6/2024 | $800,043 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG087544 | The Aging Pancreas as a Pro-tumorigenic Niche | 000 | 1 | NIH | 8/20/2024 | $243,750 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35GM147487 | Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes | 000 | 3 | NIH | 7/23/2024 | $487,500 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AR077448 | Role of Fbxw7-Mediated Proteasomal Degradation in Myofibers in Determining Muscle Stem Cell Pool Size | 000 | 4 | NIH | 7/2/2024 | $631,857 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U54AG079758 | Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics | 001 | 3 | NIH | 7/8/2024 | $2,690,250 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA276193 | Discovery of Novel Inhibitors Targeting trans-Golgi Network Acidification in Pancreatic Cancer | 001 | 2 | NIH | 4/17/2024 | $32,253 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071465 | Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brain | 000 | 5 | NIH | 5/16/2024 | $924,514 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA237536 | Non-Canonical Phosphatidylinositol Kinases in Triple Negative Breast Cancer | 000 | 5 | NIH | 5/22/2024 | $423,760 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI167977 | Comparative resistomics of Gram-negative bacterial pathogens | 001 | 3 | NIH | 5/21/2024 | $73,349 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P30CA030199 | Cancer Center Support Grant (CCSG) | 000 | 43 | NIH | 5/20/2024 | $4,081,820 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R33HL161804 | Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis | 000 | 3 | NIH | 4/26/2024 | $596,061 |
| | 2024 | 2024 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK134099 | Augmented Notch signaling as a therapeutic approach for Alagille Syndrome | 000 | 3 | NIH | 5/14/2024 | $411,840 |
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