| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2023 ( Subtotal = $48,019,370 ) (Continued on the next page) |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P30CA030199 | Cancer Center Support Grant (CCSG) | 001 | 42 | NIH | 9/18/2023 | $500,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG062557 | Targeting neuroinflammation in AD with novel CX3CR1 agonists | 000 | 5 | NIH | 2/24/2023 | $554,644 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01NS105969 | Brain pathology and function in a chronic mouse model of ZIKV transmission | 000 | 5 | NIH | 4/25/2023 | $654,901 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P30CA030199 | Cancer Center Support Grant (CCSG) | 000 | 42 | NIH | 6/7/2023 | $4,081,820 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01MH123826 | A Pharmacochaperone-based strategy for identifying chemical probes of brain-derived orphan GPCRs | 000 | 4 | NIH | 3/30/2023 | $871,671 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG062190 | "A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways" | 000 | 5 | NIH | 1/11/2023 | $974,957 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01GM131374 | Eph Receptor Heterointeractions in Signaling | 001 | 5 | NIH | 7/31/2023 | $511,800 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | RF1AG056130 | Molecular pathobiology of soluble TREM2 in Alzheimer's disease | 000 | 2 | NIH | 8/18/2023 | $2,655,773 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA237536 | Non-Canonical Phosphatidylinositol Kinases in Triple Negative Breast Cancer | 000 | 4 | NIH | 5/31/2023 | $437,141 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 000 | 4 | NIH | 1/26/2023 | $929,705 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P01HL131474 | Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis | 000 | 8 | NIH | 5/26/2023 | $2,676,393 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG065541 | Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains | 001 | 4 | NIH | 1/27/2023 | $83,809 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG062617 | Discovery of Selective Inhibitors for the EphA4 Kinase | 000 | 4 | NIH | 1/27/2023 | $760,964 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA207189 | Regulation of Nutrient Stress-Induced Macropinocytosis in Pancreatic Ductal Adenocarcinoma | 000 | 8 | NIH | 8/10/2023 | $456,813 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI148668 | Characterizing the nuclear pore complex-T cell receptor connection | 000 | 4 | NIH | 11/15/2022 | $653,587 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071464 | Defining chromostasis - a candidate regulator of healthy aging and longevity | 000 | 4 | NIH | 6/12/2023 | $809,706 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL149992 | Genetic Pathways in Ceramide-Associated Lipotoxic Cardiomyopathy and Heart Failure | 000 | 4 | NIH | 11/16/2022 | $438,750 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL149992 | Genetic Pathways in Ceramide-Associated Lipotoxic Cardiomyopathy and Heart Failure | 001 | 4 | NIH | 2/11/2023 | $48,750 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG083782 | Testing the utility of miBioAge as a personalized aging biomarker | 000 | 1 | NIH | 9/14/2023 | $569,786 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U01DA057847 | Safety/Toxicology, ADME and CMC Activities to Support the Assessment of the mGlu2 PAM SBP-9330 in a Phase 2 Clinical Study in Smokers | 000 | 1 | NIH | 9/18/2023 | $3,064,047 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AI167977 | Comparative resistomics of Gram-negative bacterial pathogens | 000 | 2 | NIH | 12/6/2022 | $733,500 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | K99AG073450 | Mitonuclear signaling pathways in senescence-associated inflammation | 000 | 2 | NIH | 8/15/2023 | $117,979 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA269339 | Targeting ER+ Breast Cancer Through Induced Viral Mimicry | 000 | 2 | NIH | 3/31/2023 | $437,141 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA267103 | Targeting the FBXO44/SUV39H1 Pathway in Cancer | 000 | 2 | NIH | 1/30/2023 | $437,141 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AA030888 | Optimization of Drug-like Properties of CRFBP-CRF2 Negative Allosteric Modulators for Alcohol Use Disorder | 000 | 1 | NIH | 9/19/2023 | $851,142 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266828 | Discovery of Glutaryl-CoA Dehydrogenase inhibitors for melanoma and pancreatic cancer | 000 | 2 | NIH | 3/2/2023 | $599,074 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01NS132780 | Investigation of ecDNA as a driver of intratumoral heterogeneity and treatment resistance in high-risk medulloblastoma | 000 | 1 | NIH | 8/24/2023 | $660,522 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG075446 | Epigenetic drift of the Aging Heart in Drosophila | 000 | 2 | NIH | 4/10/2023 | $243,750 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R37CA270362 | Regulation of the tumor microenvironment by DNA damage repair proteins | 000 | 1 | NIH | 7/14/2023 | $498,188 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R50CA283813 | Development and Implementation of Advanced Technologies for Cancer Metabolism Research | 000 | 1 | NIH | 8/1/2023 | $142,032 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R35GM147487 | Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes | 000 | 2 | NIH | 7/20/2023 | $487,500 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | P01AG073084 | Aging as a Risk Factor and Target for Prevention of Liver Cancer | 000 | 3 | NIH | 8/16/2023 | $2,585,419 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | UH3DA050316 | Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders | 000 | 2 | NIH | 9/8/2023 | $5,014,452 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | S10OD032408 | Acquisition of Zeiss LSM980 with Airyscan 2, a super-resolution point scanning confocal microscope | 001 | 1 | NIH | 8/24/2023 | $96,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | F99CA274682 | The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly | 001 | 2 | NIH | 8/1/2023 | $35,294 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA254806 | Regulation and Function of Stromal Macropinocytosis in Pancreatic Ductal Adenocarcinoma | 000 | 3 | NIH | 8/22/2023 | $574,084 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | S10OD032408 | Acquisition of Zeiss LSM980 with Airyscan 2, a super-resolution point scanning confocal microscope | 001 | 1 | NIH | 8/24/2023 | -$96,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | S10OD032408 | Acquisition of Zeiss LSM980 with Airyscan 2, a super-resolution point scanning confocal microscope | 000 | 1 | NIH | 6/2/2023 | $600,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01CA266973 | GCDH Addiction in Melanoma | 000 | 2 | NIH | 7/25/2023 | $721,672 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AR078559 | Mechanisms that couple irregular development of fetal melanoblasts to premature exhaustion of adult melanocyte stem cells | 000 | 3 | NIH | 5/22/2023 | $607,182 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK132689 | Improving Proinsulin Folding to Ameliorate Type II Diabetes | 001 | 1 | NIH | 5/26/2023 | $0 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK134099 | Augmented Notch signaling as a therapeutic approach for Alagille Syndrome | 000 | 2 | NIH | 5/10/2023 | $429,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01HL153645 | Discovery of small molecule regulators of atrial cardiomyocyte action potential duration to restore normal cardiac rhythm in atrial fibrillation | 000 | 3 | NIH | 5/18/2023 | $487,500 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01DK132689 | Improving Proinsulin Folding to Ameliorate Type II Diabetes | 000 | 1 | NIH | 5/5/2023 | $809,598 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | U54AG079758 | Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics | 001 | 2 | NIH | 7/17/2023 | $2,690,250 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01EY031745 | Retinoic acid target genes and transcriptional mechanisms during eye development | 000 | 3 | NIH | 7/14/2023 | $390,000 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R00NS120278 | Spatial Regulators of Skeletal Muscle Regeneration and Disease | 000 | 3 | NIH | 6/29/2023 | $248,721 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R21AG075483 | Novel Strategy to Quantitate Delayed Aging by Caloric Restriction | 000 | 2 | NIH | 2/3/2023 | $250,212 |
| | 2023 | 2023 | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | 10901 N TORREY PINES RD | LA JOLLA | CA | 92037-1005 | SAN DIEGO | USA | R01AG071861 | Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions | 000 | 3 | NIH | 3/6/2023 | $393,372 |
|
