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Mechanisms of Eukaryotic Gene Regulation

Award Number: R35GM118060
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/18/2016
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Mechanisms of Eukaryotic Gene Regulation - Project Summary/Abstract The major long-term objective of this research program is to understand the mechanisms of regulation of RNA polymerase II transcription in animals. Why is it important to study gene expression? The basis of a diverse range of biological phenomena, including many human diseases, can be traced to the proper or improper expression of a gene or set of genes. Thus, new insights into the mechanisms of gene expression will have a far-reaching impact upon the biological sciences. Specific emphasis will be placed upon the study of the RNA polymerase II core promoter, which is the short stretch of DNA that directs the initiation of transcription. Why is it important to study the core promoter? First, the core promoter is the gateway to transcription – the site of convergence of the signals that lead to transcription initiation. In this regard, the core promoter is at a key strategic position in the transcription process. Second, the core promoter is a central and integral component of the RNA polymerase II transcription system that comprises the signals in the chromatin (including DNA sequence motifs) and the factors that read those signals and carry out the transcription process. At present, core promoter elements are best understood in organisms other than humans. The human core promoter, which is complex and difficult to decipher, is the next challenge. Hence, future goals include the elucidation of the components of the human core promoter and the identification and analysis of the transcription factors that function with specific sequence elements to mediate the regulation of gene expression in humans. This work should provide new and important insights into the mechanisms of transcriptional regulation in humans. A second objective of this research program is to understand the diverse functions of chromatin – the natural form of DNA in the eukaryotic nucleus. Because DNA is the genetic material and is thus of the utmost importance, there is a strong and broad interest in the factors and mechanisms that affect chromatin and DNA structure and integrity. In particular, these processes will be investigated at the interface of chromatin and DNA – that is, in the context of chromatin rather than with DNA alone. One particular area of interest is the study of factors that protect DNA from damage by binding to nucleosomes. New insights into the protection of DNA against damaging agents such as reactive oxygen species would not only provide important fundamental knowledge of cellular function, but would also be relevant to the understanding and prevention of cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $692,202 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	10	4/3/2025	NON-COMPETING CONTINUATION	$692,202
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	9	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $692,202

Issue Date FY: 2024 ( Subtotal = $704,485 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	9	4/25/2024	NON-COMPETING CONTINUATION	$622,982
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	9	9/4/2024	SUPPLEMENT FOR EXPANSION	$12,283
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	9	7/17/2024	NON-COMPETING CONTINUATION	$69,220
														Subtotal = $704,485

Issue Date FY: 2023 ( Subtotal = $692,202 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	8	5/5/2023	NON-COMPETING CONTINUATION	$692,202
														Subtotal = $692,202

Issue Date FY: 2022 ( Subtotal = $704,335 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	7	3/30/2022	NON-COMPETING CONTINUATION	$622,982
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	7	7/1/2022	NON-COMPETING CONTINUATION	$69,220
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	7	9/20/2022	SUPPLEMENT FOR EXPANSION	$12,133
														Subtotal = $704,335

Issue Date FY: 2021 ( Subtotal = $691,846 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	6	9/10/2021	COMPETING CONTINUATION	$15,002
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	6	4/27/2021	COMPETING CONTINUATION	$691,846
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	5	9/10/2021	NON-COMPETING CONTINUATION	-$15,002
														Subtotal = $691,846

Issue Date FY: 2020 ( Subtotal = $662,756 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	5	4/10/2020	NON-COMPETING CONTINUATION	$651,455
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	5	5/29/2020	SUPPLEMENT FOR EXPANSION	$11,301
														Subtotal = $662,756

Issue Date FY: 2019 ( Subtotal = $675,614 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	4	4/26/2019	NON-COMPETING CONTINUATION	$651,455
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	4	9/23/2019	SUPPLEMENT FOR EXPANSION	$17,651
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	3	3/18/2019	SUPPLEMENT FOR EXPANSION	$6,508
														Subtotal = $675,614

Issue Date FY: 2018 ( Subtotal = $734,221 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	3	3/19/2018	NON-COMPETING CONTINUATION	$609,784
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	3	5/25/2018	NON-COMPETING CONTINUATION	$67,754
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	3	8/23/2018	SUPPLEMENT FOR EXPANSION	$56,683
														Subtotal = $734,221

Issue Date FY: 2017 ( Subtotal = $703,622 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	2	8/17/2017	NON-COMPETING CONTINUATION	$65,146
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	2	4/26/2017	NON-COMPETING CONTINUATION	$586,309
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	2	8/3/2017	SUPPLEMENT FOR EXPANSION	$52,167
														Subtotal = $703,622

Issue Date FY: 2016 ( Subtotal = $413,630 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	1	8/2/2016	SUPPLEMENT FOR EXPANSION	$25,807
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	1	4/18/2016	NEW	$387,823
														Subtotal = $413,630

Grand Total All Awards = $6,674,913

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Mechanisms of Eukaryotic Gene Regulation

Award Number: R35GM118060

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/18/2016

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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