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Environmental Liver Disease

Award Number: R35ES028373
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Environmental Liver Disease - Liver disease is a major global health problem. Fatty liver disease, or excess accumulation of lipids in hepatocytes, affects more than 25% of the worldwide adult population, but children and adolescents may also be affected. Chronic liver disease may progress to cirrhosis and liver cancer resulting in liver-related death or transplantation. Liver disease also impacts the development of diabetes and cardiovascular disease. Liver diseases may be caused or influenced by exposures to environmental chemicals, but this is an understudied area. To address these problems, this project establishes a major integrative and collaborative research program, the Environmental Liver Disease Revolutionizing Innovative, Visionary Environmental Health Research Program (ELD-RIVER). ELD-RIVER will have a transformative impact in the field. The project investigates two broad scientific themes: (i) the impact of endocrine and metabolism disrupting chemicals (EDCs/MDCs) in fatty liver disease, and (ii) other liver diseases (such as liver cancer) associated with chemical exposures. The ELD-RIVER takes a broad integrative scientific approach by investigating relevant chemicals; nutrient:chemical interactions; both animal models and human subjects; and both sexes through state-of-the-art methods including multi-‘omics. EDC/MDC exposures may also impact liver disease through their effects on obesity and diabetes. Thus, obesity and diabetes endpoints will also be evaluated. While the specific projects are expected to evolve over time, the initial work focusses on exposures to polychlorinated biphenyls and vinyl chloride. Both of these chemicals currently rank in the top five in the Agency for Toxic Substances and Disease Registry (ATSDR) Substance Priority List. ELD-RIVER strictly adheres to the principles of scientific rigor and reproducibility and data transparency and availability. ELD-RIVER leverages existing collaborations between multiple organizations including academia, government agencies, industry, and scientific/medical societies. The vision is for ELD-RIVER to become the global hub for environmental liver disease research. To accomplish its translational mission, the program integrates the work of basic scientists, epidemiologists, and physicians. The project will also develop diagnostic biomarkers, new treatments, practice guidelines, and it has the potential to impact policy change. Along the way, unique institutional education/training resources will be utilized so that ELD-RIVER will help produce the next generation of environmental health scientists. The work proposed is relevant to Strategic Plan of the National Institute of Environmental Health Sciences (Themes 1, 2, and 5 and Goals 1, 4, 7, and 8).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$254,353 )
2026	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	8	1/28/2026	NON-COMPETING CONTINUATION	-$254,353
														Subtotal = -$254,353

Issue Date FY: 2024 ( Subtotal = $459,584 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	8	8/16/2024	NON-COMPETING CONTINUATION	$459,584
														Subtotal = $459,584

Issue Date FY: 2023 ( Subtotal = $471,710 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	7	8/22/2023	NON-COMPETING CONTINUATION	$471,710
														Subtotal = $471,710

Issue Date FY: 2022 ( Subtotal = $483,489 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	6	8/25/2022	NON-COMPETING CONTINUATION	$483,489
														Subtotal = $483,489

Issue Date FY: 2021 ( Subtotal = $494,921 )
2021	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	5	8/9/2021	NON-COMPETING CONTINUATION	$494,921
														Subtotal = $494,921

Issue Date FY: 2020 ( Subtotal = $506,019 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	4	8/26/2020	NON-COMPETING CONTINUATION	$506,019
														Subtotal = $506,019

Issue Date FY: 2019 ( Subtotal = $517,229 )
2019	2019	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	3	8/28/2019	NON-COMPETING CONTINUATION	$517,229
														Subtotal = $517,229

Issue Date FY: 2018 ( Subtotal = $529,662 )
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	2	8/13/2018	NON-COMPETING CONTINUATION	$529,662
														Subtotal = $529,662

Issue Date FY: 2017 ( Subtotal = $550,876 )
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Environmental Health	000	1	9/12/2017	NEW	$550,876
														Subtotal = $550,876

Grand Total All Awards = $3,759,137

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Environmental Liver Disease

Award Number: R35ES028373

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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