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A Pathway-based Approach To Detecting Gene-environment Interactions Using The Personalized Environment And Genes Study

Award Number: R21ES039003
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2026
PERIOD OF PERFORMANCE END DATE: 09/10/2028

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A Pathway-based Approach To Detecting Gene-environment Interactions Using The Personalized Environment And Genes Study - SUMMARY Most common diseases are caused by both genetic factors and environmental factors. Gene-Environment interactions (GxE) describe when genetic variation influences how individuals respond to their environments. One set of genes that is particularly important to environmental response is the Aryl Hydrocarbon Receptor (AHR) and associated genes that are involved in metabolizing foreign chemicals in the body. We refer to these 29 genes as the AHR Pathway. In this research project, we will show how genetic variation in these genes interacts with common environmental exposures such as diesel exhaust to influence human diseases, such as coronary artery disease. To test this hypothesis, we will use the Personalized Environment and Genes Study (PEGS), which is a human cohort study designed specifically for identifying GxE. We map GxE and Polygenic Risk Score x Environment interactions in the PEGS cohort.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $395,056 )
2026	2026	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	1	9/10/2026	NEW	$395,056
														Subtotal = $395,056

Grand Total All Awards = $395,056

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A Pathway-based Approach To Detecting Gene-environment Interactions Using The Personalized Environment And Genes Study

Award Number: R21ES039003

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2026

PERIOD OF PERFORMANCE END DATE: 09/10/2028

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