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Improving the reliability of eye tracking to diagnose concussion

Award Number: R15NS121788
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Improving the reliability of eye tracking to diagnose concussion - PROJECT SUMMARY / ABSTRACT Although concussion or mild Traumatic Brain Injury (mTBI) affects more than a million of Americans each year, and represents a great societal burden, diagnosis is still difficult, and reliable biomarkers are still lacking. The long-term goal is to develop measurable physiological indicators that differ between healthy individuals, and those who sustained an mTBI. The overall objective in this application is to increase the reliability of using eye-movements to diagnose concussion. Circuits in the brain, devoted to vision, vestibular or oculomotor function are so omnipresent in the brain that almost any blow to the head affects sight and eye movements. Therefore, many researchers agree that eye tracking to monitor oculomotor behavior shows great potential of revealing mTBI. Results from studies, using eye movements as a biomarker to predict concussion, are encouraging, albeit not sufficiently strong to proof its clinical utility. The central hypothesis is that the inclusion of microsaccades, the tiny eye movements made when the gaze is fixed on a target, in the continuum of eye movements, will provide an improved technique to diagnose concussion. The central hypothesis will be tested by two specific aims: the first one is to increase the resolution of using eye movements to diagnose concussion. To execute this aim, participants will be recruited among the more than 300 students of Millsaps. They will conduct a ~25-minute oculomotor task while their eye movements are recorded. Athletes who sustain a head injury during the following sports season will then be invited to retake the test. The second aim is to show that monitoring eye movements are also useful in assessing to what extent an individual has recovered from injury. To execute this aim, recovering athletes will be invited to take the oculomotor task weekly. The research proposed in this application is innovative, because microsaccades have been ignored in eye tracking studies; mainly because they require high frequency sampling and specialized software. The applicant possesses both the hard- and software needed to record those elusive eye movements and his preliminary results suggest that including microsaccades will significantly increase the resolution of assessing oculomotor behavior. The research proposed in this application is significant, because eye tracking has been hailed as one of the most promising techniques to obtain a reliable and objective measurement to diagnose concussion, and recording microsaccades has the potential to advance this technique significantly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2021	UNIVERSITY ENTERPRISES CORPORATION AT CSUSB	5500 UNIVERSITY PKWY	SAN BERNARDINO	CA	92407	SAN BERNARDINO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/30/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	UNIVERSITY ENTERPRISES CORPORATION AT CSUSB	5500 UNIVERSITY PKWY	SAN BERNARDINO	CA	92407	SAN BERNARDINO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/9/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	MILLSAPS COLLEGE	1701 N STATE ST	JACKSON	MS	39210	HINDS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	6/20/2023	NEW	$0
2023	2021	MILLSAPS COLLEGE	1701 N STATE ST	JACKSON	MS	39210	HINDS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/20/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$4,936 )
2022	2021	MILLSAPS COLLEGE	1701 N STATE ST	JACKSON	MS	39210	HINDS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/24/2022	NEW	-$301,575
2022	2021	UNIVERSITY ENTERPRISES CORPORATION AT CSUSB	5500 UNIVERSITY PKWY	SAN BERNARDINO	CA	92407	SAN BERNARDINO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/25/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$296,639
														Subtotal = -$4,936

Issue Date FY: 2021 ( Subtotal = $400,492 )
2021	2021	MILLSAPS COLLEGE	1701 N STATE ST	JACKSON	MS	39210	HINDS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2021	NEW	$400,492
														Subtotal = $400,492

Grand Total All Awards = $395,556

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Improving the reliability of eye tracking to diagnose concussion

Award Number: R15NS121788

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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