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Sox proteins in neural progenitor maintenance and differentiation

Award Number: R15NS116509
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Sox proteins in neural progenitor maintenance and differentiation - Neural development involves the progression of proliferating cells to mature neurons in order to form a complete and precisely functioning central nervous system. The balance of proliferating and differentiating cells are in part controlled by changes in the expression of transcription factors, and the SoxB and C family TFs are integral to this process. Sox11, a member of the SoxC subfamily, has been shown to play a critical role in multiple steps of neural development including: establishment of neuronal identity and promotion of neural differentiation and maturation. Misregulation and loss of Sox11 function have been linked to various diseases and neurodevelopmental disorders including cervical cancer, mantle cell lymphoma and Coffin-Siris Syndrome (CSS), a disorder characterized by developmental disability and digit, facial and cardiac anomalies. Despite Sox11's significant role in development, little is known about the molecular mechanisms underlying its expression or function. In order to understand how Sox11 has different functions at different times in the development of the CNS, we will determine 1) the mechanism by which Sox11 drives the expression of distinct spatial- temporal gene targets and 2) the transcriptional and post-transcriptional mechanisms of regulation during neurogenesis. These goals have led us to identify the Sox11 partner protein interactions in space and time through development and the factors involved in controlling the dynamic expression of Sox11.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$5,617 )
2026	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	10/1/2025	NEW	-$5,617
														Subtotal = -$5,617

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/11/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/14/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $468,000 )
2020	2020	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/10/2020	NEW	$468,000
														Subtotal = $468,000

Grand Total All Awards = $462,383

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Sox proteins in neural progenitor maintenance and differentiation

Award Number: R15NS116509

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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