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Endocrine Disruption in the Bovine Antral Follicle

Award Number: R15ES024520
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2019

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Endocrine Disruption in the Bovine Antral Follicle - DESCRIPTION (provided by applicant): Endocrine disrupting compounds (EDCs) are ubiquitous, they threaten the reproduction and health of adults, yet the field fails to grasp their exact risks and mechanisms of action. Normal oocyte development is at the root of embryogenesis, development to term, and even the health of the resulting adult into late in life. There is thus a clear impetus to ensure the quality of oocytes, particularly in face of a large lis of chemical insults in our environment. Once risks, effects, and mechanisms are identified, we will then be in a position to eliminate the insult as well as manage, and even prevent, infertility and certain adult diseases. A complex, dynamic, and vulnerable follicular microenvironment permits the development of a good quality oocyte. It is thus essential to begin addressing the influences of EDCs, including bisphenol-A (BPA), on the function and development of not only the oocyte itself but also each cellular compartment making up the antral follicle. There are numerous experimental limitations to investigations thus far, among which is the fact that an animal model in which the specifics of folliculogenesis and oogenesis recapitulate most closely those occurring in human has not been employed. The bovine model fills in such gap, along with providing many other experimental advantages. With a focus on the bovine oocyte and antral follicle, this research program is particularly well suited to resolve the existing challengs in the field. The proposed experiments will: 1) measure systemic (in serum and urine) and intrafollicular (in follicular fluid) levels of EDCs in three groups of cows (abattoir animals, a conventional dairy herd, and an organic dairy herd); and 2) determine the effects of BPA on the development and function of bovine oocytes, granulosa cells, and theca cells derived from antral follicles. The assessment of cellular differentiation state and function will include meioti progression and chromosomal segregation (for oocytes), cell proliferation and cell death (for granulosa and theca cells), production of steroids and other essential secreted factors (for granulosa and theca cells), redox and pro-/anti-oxidant states (for all cell types), and ability to support early embryonic development (for oocytes). Such comprehensive assessment of EDCs in the follicular milieu and BPA effects on the antral follicle will provide essential knowledge fo future studies and in the long-term, for the protection of human reproductive and adult health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$4,791 )
2020	2014	PRESIDENT AND FELLOWS OF MIDDLEBURY COLLEGE	38 COLLEGE ST	MIDDLEBURY	VT	05753	ADDISON	USA	Environmental Health	000	1	10/1/2019	NEW	-$4,791
														Subtotal = -$4,791

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2014	PRESIDENT AND FELLOWS OF MIDDLEBURY COLLEGE	38 COLLEGE ST	MIDDLEBURY	VT	05753	ADDISON	USA	Environmental Health	000	1	5/6/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2014	PRESIDENT AND FELLOWS OF MIDDLEBURY COLLEGE	38 COLLEGE ST	MIDDLEBURY	VT	05753	ADDISON	USA	Environmental Health	000	1	5/1/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $410,492 )
2014	2014	MIDDLEBURY COLLEGE	OLD CHAPEL BUILDING	MIDDLEBURY	VT	05753	ADDISON	USA	Environmental Health	001	1	8/8/2014	NEW	-$23,858
2014	2014	MIDDLEBURY COLLEGE	OLD CHAPEL BUILDING	MIDDLEBURY	VT	05753	ADDISON	USA	Environmental Health	000	1	7/15/2014	NEW	$434,350
														Subtotal = $410,492

Grand Total All Awards = $405,701

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Endocrine Disruption in the Bovine Antral Follicle

Award Number: R15ES024520

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2019

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