Research and Education towards Solutions for Late effects to Innovate, Excel, and Nurture after chronic Graft-versus-Host Disease (RESILIENT after cGVHD) - Project Summary/ Abstract The overarching goal of the Research and Education towards Solutions for Late effects to Innovate, Excel, and Nurture after chronic Graft-versus-Host Disease (RESILIENT after cGVHD) consensus conference is to address the 1) state of the science, 2) recommendations for clinical care, and 3) research priorities for pediatric survivors of Hematopoetic cell transplantation (HCT) diagnosed with cGVHD. The conference is expected to include approximately 150-200 members/ stakeholders of the pediatric HCT community. This one day conference will take place in the same location, and one day prior to the start of the annual to the American Society of Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplantation Research (CIBMTR) Tandem Meetings, the largest HCT meeting in North America. The RESILIENT after cGVHD consensus conference is being led by the Pediatric Transplantation and Cellular Therapy (PTCTC) Late-Effects and Graft-versus-Host Disease strategy groups. Prior to the conference four working comittees have been formed to develop key topics for long-term survivors with cGVHD: 1) Phases of cGVHD, 2) Organ Dysfunction and Immunity, 3) Metabolism, Growth and Development, and 4) Patient Important Outcomes. Each working group is co-lead by a member with expertise in GVHD and a member with expertise in survivorship, and includes 5-7 additional members. Meticulous attention has been paid to ensure the composition of working committees represents experts with diverse backgrounds based on several criteria including: career stage, race, gender, and ethnicity, geographic location across the United States and Canada, HCT program size (i.e. how many HCTs are performed each year, is the program part of a single health system or a standalone children’s hospital), and credentials (e.g. inclusion of pharmacists, psychologists, nurses, physician assistants, physicians, physical therapist). Working group diversity also encompasses experts in research and clinical care to promote both advances in clinical care that could be adapted quickly and broad research questions that could be addressed through collaborations in these groups. The working committees will present their preliminary findings at the consensus conference which will then be followed by a forum for open discussion. Finally, manuscripts from each working group will be submitted for peer-reviewed publication and dissemination throughout the HCT Community.
