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 | Issue Date FY: 2023 ( Subtotal = $26,501,458 ) (Continued on the next page) |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35NS097303 | Pathogenesis of Neurological Disability in Primary Diseases of Myelin | 001 | 7 | NIH | 2/6/2023 | $0 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG080486 | Digital Twin Neighborhoods for Research on Place-Based Health Inequalities in Mid-Life | 000 | 1 | NIH | 12/28/2022 | $465,501 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG080486 | Digital Twin Neighborhoods for Research on Place-Based Health Inequalities in Mid-Life | 000 | 1 | NIH | 12/28/2022 | $150,000 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124547 | The mammalian multi-tRNA synthetase complex | 000 | 2 | NIH | 12/2/2022 | $433,715 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA244958 | Mechanisms of nuclear Mcl-1 mediated chemoresistance | 000 | 3 | NIH | 11/15/2022 | $331,459 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U54CA274513 | Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies | 000 | 1 | NIH | 3/20/2023 | $36,982 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124081 | lncRNA regulation of glioblastoma progression and therapeutic resistance | 001 | 2 | NIH | 1/31/2023 | $54,720 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124081 | lncRNA regulation of glioblastoma progression and therapeutic resistance | 000 | 2 | NIH | 12/2/2022 | $492,501 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI150931 | Manipulation of host factors that promote HCMV latency | 000 | 3 | NIH | 1/13/2023 | $470,877 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01MH124530 | Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and Genetics | 000 | 3 | NIH | 3/10/2023 | $444,052 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA244958 | Mechanisms of nuclear Mcl-1 mediated chemoresistance | 001 | 3 | NIH | 3/15/2023 | $29,463 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL060917 | Nitric Oxide in Pulmonary Hypertension | 001 | 24 | NIH | 3/15/2023 | $75,910 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124581 | Childhood-onset hypomyelinating leukodystrophy and the multi-tRNA synthetase complex | 000 | 1 | NIH | 12/15/2022 | $626,635 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS123532 | Understanding role of circadian disruption in pathogenesis of MS | 000 | 2 | NIH | 3/1/2023 | $470,782 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL160747 | Gut-microbial metabolism of aromatic amino acids and cardiovascular disease | 001 | 2 | NIH | 3/6/2023 | $55,811 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA257502 | Discovering the role of YES1 in triple negative breast cancer | 000 | 3 | NIH | 1/31/2023 | $452,109 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS119178 | The role of the astrocyte immunoproteasome during chronic CNS autoimmunity | 000 | 3 | NIH | 12/5/2022 | $362,250 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS119178 | The role of the astrocyte immunoproteasome during chronic CNS autoimmunity | 001 | 3 | NIH | 1/31/2023 | $40,250 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL060917 | Nitric Oxide in Pulmonary Hypertension | 000 | 24 | NIH | 1/13/2023 | $683,196 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL162772 | Novel regulation of beta-adrenergic receptor function by phosphoinositide 3-kinase | 000 | 1 | NIH | 12/14/2022 | $637,731 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL160747 | Gut-microbial metabolism of aromatic amino acids and cardiovascular disease | 000 | 2 | NIH | 12/4/2022 | $502,296 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AT011905 | Sensing active movement of the self: reconsidering the cellular basis kinesthesia | 000 | 2 | NIH | 1/19/2023 | $524,355 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K23HL150279 | Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric Analyses | 002 | 3 | NIH | 2/27/2023 | $172,788 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35HL135795 | Therapeutic Implications of Molecular Defects in Bone Marrow Failure | 001 | 7 | NIH | 1/25/2023 | $122,674 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI040459 | Post-Transplant Inflammatory Response | 000 | 24 | NIH | 11/14/2022 | $483,002 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK135265 | Mechanisms of Kidney Diseases Associated With APOL1 Variation | 001 | 1 | NIH | 2/17/2023 | $0 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG067146 | Adipokines, Aging, and Alzheimers Disease | 000 | 4 | NIH | 3/15/2023 | $474,473 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35HL135795 | Therapeutic Implications of Molecular Defects in Bone Marrow Failure | 002 | 7 | NIH | 3/3/2023 | $95,100 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK135265 | Mechanisms of Kidney Diseases Associated With APOL1 Variation | 000 | 1 | NIH | 2/2/2023 | $701,266 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K00CA253768 | Sex Differences in Blood-Brain and Blood-Tumor Barrier Dynamics in Glioblastoma | 000 | 4 | NIH | 11/22/2022 | $90,746 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI160740 | Mechanisms of alloantibody production following renal transplantation | 000 | 3 | NIH | 1/9/2023 | $596,809 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG066627 | Early Stage Studies of a Novel Positive Allosteric Modulator of the Alpha1-Adrenergic Receptor to Treat Alzheimer's Disease | 000 | 4 | NIH | 3/15/2023 | $402,500 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS110700 | T cell-dependent regulation of microglia demyelinating functions | 000 | 5 | NIH | 1/28/2023 | $352,188 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35HL135795 | Therapeutic Implications of Molecular Defects in Bone Marrow Failure | 000 | 7 | NIH | 1/17/2023 | $855,900 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K99CA277136 | Modifiable Determinants of Disparities in Multiple Myeloma Treatment Patterns | 000 | 1 | NIH | 2/1/2023 | $160,018 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F32CA268665 | Elucidating a novel metabolic mechanism of glucosamine-driven treatment resistance in castration-resistant prostate cancer through stimulation of 3b-HSD1-mediated DHEA metabolism | 000 | 2 | NIH | 2/28/2023 | $73,772 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08AA028794 | Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease | 000 | 3 | NIH | 2/20/2023 | $179,129 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK121689 | The role of acetogenic, methanogenic, and sulfate-reducing bacteria in oxalate metabolism and hyperoxaluria | 000 | 4 | NIH | 2/23/2023 | $451,797 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08HL141598 | Personalizing Preoperative Stress Testing Using Machine Learning | 000 | 5 | NIH | 1/30/2023 | $161,047 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA223370 | Targeting oncogenic dopamine receptor signaling in glioblastoma | 001 | 5 | NIH | 3/15/2023 | $38,503 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | T32EY024236 | Cole Eye Institute Vision Science Training Program | 000 | 8 | NIH | 2/27/2023 | $36,248 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL161674 | Gender and Asthma | 000 | 1 | NIH | 12/22/2022 | $419,061 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA261995 | CYP17A1-independent androgen synthesis and prostate cancer resistance to next-generation hormonal therapy | 000 | 2 | NIH | 1/25/2023 | $360,922 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG070736 | CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer?s Disease | 000 | 3 | NIH | 1/23/2023 | $1,544,290 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG066707 | Endophenotype Network-based Approaches to Prediction and Population-based Validation of in Silico Drug Repurposing for Alzheimer?s Disease | 000 | 4 | NIH | 1/26/2023 | $721,981 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA223370 | Targeting oncogenic dopamine receptor signaling in glioblastoma | 000 | 5 | NIH | 11/2/2022 | $433,159 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE028521 | KSHVmediated regulation of proline metabolism | 000 | 6 | NIH | 11/22/2022 | $415,955 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE023926 | KSHV Epigenetic Regulation | 000 | 10 | NIH | 11/22/2022 | $388,045 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA277966 | Macrophage-based Therapy and Immune Checkpoint Blockade for Glioblastoma | 000 | 1 | NIH | 11/30/2022 | $368,288 |
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