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 | Issue Date FY: 2025 ( Subtotal = $13,926,200 ) (Continued on the next page) |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R13AR083805 | Clinical Scholars Career Development Program (CSCDP) | 000 | 2 | NIH | 1/13/2025 | $30,000 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG070736 | CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease | 000 | 5 | NIH | 1/8/2025 | $1,006,459 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AT011905 | Sensing active movement of the self: reconsidering the cellular basis kinesthesia | 000 | 4 | NIH | 1/16/2025 | $499,836 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS132437 | The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) Trial | 000 | 2 | NIH | 1/10/2025 | $552,473 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R03EB034863 | Development of motion correction algorithms for functional MRI data using a custom simultaneously excited multi-slice MRI acquisition with prospectively injected motion | 000 | 1 | NIH | 1/21/2025 | $80,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R61HL171717 | Small Molecule Therapeutic for Heart Failure | 000 | 2 | NIH | 12/17/2024 | $499,322 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE033391 | Molecular mechanism of Zika virus-induced premature craniofacial suture closure | 000 | 2 | NIH | 12/17/2024 | $362,250 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AI182702 | Modulation of Monocyte and T Cell Functions by Immune Inhibitory Receptors during Subclinical Malaria | 000 | 1 | NIH | 12/19/2024 | $184,109 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31EY035133 | Characterizing the role of mitochondrial DNA mutations on retinal degeneration. | 000 | 2 | NIH | 1/14/2025 | $48,974 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08HL168348 | Nocturnal hypoxemia dysregulates skeletal muscle protein homeostasis in COPD | 000 | 1 | NIH | 12/24/2024 | $151,578 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG086247 | Improving colorectal cancer screening decisions through consideration of life expectancy | 000 | 1 | NIH | 12/31/2024 | $625,452 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK135265 | Mechanisms of Kidney Diseases Associated With APOL1 Variation | 000 | 3 | NIH | 12/31/2024 | $615,838 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG080486 | Digital Twin Neighborhoods for Research on Place-Based Health Inequalities in Mid-Life | 000 | 3 | NIH | 12/30/2024 | $636,431 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124547 | The mammalian multi-tRNA synthetase complex | 000 | 4 | NIH | 12/26/2024 | $433,715 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35GM156762 | Synthetic biology tools and strategies to streamline the sensing and responding to disease cues in engineered theragnostic bacteria. | 000 | 1 | NIH | 12/26/2024 | $402,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01MH124530 | Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and Genetics | 000 | 5 | NIH | 12/24/2024 | $353,731 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124581 | Childhood-onset hypomyelinating leukodystrophy and the multi-tRNA synthetase complex | 000 | 3 | NIH | 12/3/2024 | $563,973 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124081 | lncRNA regulation of glioblastoma progression and therapeutic resistance | 000 | 4 | NIH | 11/20/2024 | $492,501 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS119178 | The role of the astrocyte immunoproteasome during chronic CNS autoimmunity | 000 | 5 | NIH | 11/19/2024 | $362,250 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL160747 | Gut-microbial metabolism of aromatic amino acids and cardiovascular disease | 000 | 4 | NIH | 11/6/2024 | $502,296 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI040459 | Post-Transplant Inflammatory Response | 000 | 26 | NIH | 11/15/2024 | $505,876 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI168411 | Innate immune responses to tissue infection by intestinal fungi inhibit wound repair | 000 | 2 | NIH | 11/4/2024 | $771,486 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R00DE031372 | Role of sulfide in oral microbiota-host interactions that promote periodontitis | 000 | 4 | NIH | 10/25/2024 | $249,000 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F32DK136180 | Internalization of dead cells governs intestinal stem cell activity | 000 | 2 | NIH | 12/23/2024 | $77,284 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL167831 | Gut microbial dietary phenylalanine metabolism and heart failure | 000 | 2 | NIH | 1/13/2025 | $711,062 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA244958 | Mechanisms of nuclear Mcl-1 mediated chemoresistance | 000 | 5 | NIH | 11/26/2024 | $331,459 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01MH133584 | Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors | 000 | 1 | NIH | 12/13/2024 | $241,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS137230 | Molecular Mechanism of Glucocorticoid Receptor, Cytochrome P450, and P-Glycoprotein Axis on Drug Regulation at the Blood-Brain Barrier in Epilepsy with Focal Cortical Dysplasia | 000 | 1 | NIH | 12/5/2024 | $431,676 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK137822 | Actin methylation as a novel mechanism that regulates gut barrier integrity and repair | 000 | 2 | NIH | 12/17/2024 | $479,101 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R37CA295609 | Molecular mediators of disparate outcomes experienced by patients of African ancestry with lung cancer | 000 | 1 | NIH | 12/4/2024 | $368,288 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K01NS136791 | Analysis of C9ORF72-associated poly (GR) interactions on BAF chromatin remodeling complex structure and function | 000 | 1 | NIH | 12/10/2024 | $236,668 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31AI174784 | Host and microbe-dependent mechanisms of enhanced autoimmune susceptibility driven by checkpoint inhibitors | 000 | 2 | NIH | 12/17/2024 | $53,974 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK126772 | Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine | 000 | 5 | NIH | 12/12/2024 | $433,135 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K23ES035447 | Air Pollution, Environmental Injustice and Progressive Pulmonary Fibrosis | 000 | 1 | NIH | 12/12/2024 | $241,811 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL162772 | Novel regulation of beta-adrenergic receptor function by phosphoinositide 3-kinase | 000 | 3 | NIH | 11/29/2024 | $573,958 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG070736 | CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease | 000 | 5 | NIH | 1/8/2025 | $349,512 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA277966 | Macrophage-based Therapy and Immune Checkpoint Blockade for Glioblastoma | 000 | 3 | NIH | 11/25/2024 | $331,459 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35NS097303 | Pathogenesis of Neurological Disability in Primary Diseases of Myelin | 000 | 8 | NIH | 1/17/2025 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AR084758 | Evaluating Over Constraint of the Patella following MPFL Reconstruction as a Contributing Factor to Progressive Cartilage Degradation | 000 | 1 | NIH | 12/24/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K25AG070321 | Characterization of sarcopenia in heart failure by T1rho magnetic resonance fingerprinting | 001 | 3 | NIH | 12/30/2024 | -$139,170 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | P30AG072959 | Cleveland Alzheimers Disease Research Center | 000 | 4 | NIH | 11/13/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U01DK114908 | Cleveland Precision Medicine Chronic Kidney Disease Cohort | 000 | 8 | NIH | 11/14/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HD105049 | Modeling Autism and Comorbid Cancer Risk in Individuals with Germline PTEN Mutations | 000 | 3 | NIH | 12/3/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35HG011922 | Model-based methods for single cell chromatin interactomic data | 000 | 4 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R33AG069729 | A Cognitive Risk Calculator and Screening tool for Primary Care Settings | 000 | 5 | NIH | 11/15/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35GM149240 | Immune Function in Sepsis: Role of Sirtuin | 000 | 2 | NIH | 11/7/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U01CA294881 | Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study | 000 | 1 | NIH | 12/5/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01EB024573 | Reproducibility in simulation-based prediction of natural knee mechanics | 000 | 6 | NIH | 10/15/2024 | $0 |
| | 2025 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS135080 | Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy | 000 | 1 | NIH | 12/5/2024 | $0 |
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