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 | Issue Date FY: 2024 ( Subtotal = $7,068,994 ) |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL160747 | Gut-microbial metabolism of aromatic amino acids and cardiovascular disease | 000 | 3 | NIH | 11/22/2023 | $502,296 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA277966 | Macrophage-based Therapy and Immune Checkpoint Blockade for Glioblastoma | 000 | 2 | NIH | 11/6/2023 | $331,459 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA244958 | Mechanisms of nuclear Mcl-1 mediated chemoresistance | 000 | 4 | NIH | 11/9/2023 | $331,459 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R37CA244613 | Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung Cancer | 000 | 5 | NIH | 11/29/2023 | $402,867 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI168411 | Innate immune responses to tissue infection by intestinal fungi inhibit wound repair | 000 | 1 | NIH | 11/14/2023 | $729,559 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI040459 | Post-Transplant Inflammatory Response | 000 | 25 | NIH | 11/9/2023 | $434,702 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35NS097303 | Pathogenesis of Neurological Disability in Primary Diseases of Myelin | 000 | 8 | NIH | 11/9/2023 | $784,575 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R00DE031372 | Role of sulfide in oral microbiota-host interactions that promote periodontitis | 000 | 3 | NIH | 11/7/2023 | $249,000 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124581 | Childhood-onset hypomyelinating leukodystrophy and the multi-tRNA synthetase complex | 000 | 2 | NIH | 12/4/2023 | $563,973 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124081 | lncRNA regulation of glioblastoma progression and therapeutic resistance | 000 | 3 | NIH | 12/4/2023 | $492,501 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS119178 | The role of the astrocyte immunoproteasome during chronic CNS autoimmunity | 000 | 4 | NIH | 11/10/2023 | $362,250 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL162772 | Novel regulation of beta-adrenergic receptor function by phosphoinositide 3-kinase | 000 | 2 | NIH | 11/8/2023 | $573,958 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F32DK136180 | Internalization of dead cells governs intestinal stem cell activity | 001 | 1 | NIH | 11/30/2023 | $0 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F32DK136180 | Internalization of dead cells governs intestinal stem cell activity | 000 | 1 | NIH | 11/30/2023 | $71,580 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE023926 | KSHV Epigenetic Regulation | 000 | 11 | NIH | 11/3/2023 | $388,045 |
| | 2024 | 2024 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31EY035133 | Characterizing the role of mitochondrial DNA mutations on retinal degeneration. | 000 | 1 | NIH | 11/30/2023 | $47,694 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U2CDK129440 | Cleveland Kidney, Urology and Hematology Training Network | 000 | 3 | NIH | 11/28/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U01NS116776 | Central Vein Sign: A Diagnostic Biomarker in Multiple Sclerosis | 000 | 3 | NIH | 11/6/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK121019 | Protective factors in diabetic kidney disease in patients with type 1 diabetes | 002 | 4 | NIH | 10/25/2023 | $719,885 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U01DK114908 | Cleveland Precision Medicine Chronic Kidney Disease Cohort | 000 | 7 | NIH | 11/30/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R56NS134148 | Endogenous synthesis of TRAIL by glioma cancer stem cells and resistance to TRAIL therapy | 000 | 1 | NIH | 12/4/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AT011005 | Feasibility and Acceptability of Telephone-delivered MBCT for Migraine and Depression (FATE-MD) | 001 | 3 | NIH | 10/11/2023 | $627,390 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R56AG079897 | Integrin regulation of vascular function in Alzheimer's disease | 000 | 1 | NIH | 10/13/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AG083003 | Precision Medicine Digital Twins for Alzheimer?s Target and Drug Discovery and Longevity | 000 | 1 | NIH | 10/13/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | P50AA024333 | Alcohol and tissue injury, from mechanisms to treatments | 000 | 8 | NIH | 10/24/2023 | $0 |
| | 2024 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | P30AG072959 | Cleveland Alzheimers Disease Research Center | 000 | 3 | NIH | 10/14/2023 | $0 |
| | 2024 | 2022 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35CA200422 | Molecular Basis of KSHV oncogenesis | 000 | 8 | NIH | 12/6/2023 | $0 |
| | 2024 | 2022 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08CA237842 | Chromatin Modifier Gene Mutation and Enhancer Dysfunction in Bladder Cancer | 000 | 4 | NIH | 10/13/2023 | -$199,535 |
| | 2024 | 2022 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL156987 | Impact of microfibril turnover on vascular development and disease | 000 | 1 | NIH | 10/23/2023 | -$253,491 |
| | 2024 | 2022 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL094505 | ER-to-Golgi transport of coagulation factors V and VIII | 000 | 13 | NIH | 10/13/2023 | $0 |
| | 2024 | 2022 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U01HL143402 | Novel approaches to improve prediction of cancer-associated thrombosis | 000 | 5 | NIH | 11/6/2023 | $0 |
| | 2024 | 2021 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01CA205426 | Elucidating genetics of response to immune checkpoint blockade in lung cancer | 000 | 6 | NIH | 10/13/2023 | $0 |
| | 2024 | 2021 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AA027456 | Transcriptional and non-transcriptional functions of IRF3 in ALD | 000 | 3 | NIH | 11/9/2023 | $0 |
| | 2024 | 2021 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL142772 | Platelets in Cancer | 000 | 4 | NIH | 10/11/2023 | $0 |
| | 2024 | 2021 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL141892 | Impact of Disparities Affecting Survival among Advanced Heart Failure Patients and Transplant Recipients | 000 | 4 | NIH | 12/1/2023 | -$57,553 |
| | 2024 | 2021 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL139984 | Development of a Miniaturized, Pediatric Continuous-Flow Total Artificial Heart with a Single Moving Part | 000 | 4 | NIH | 12/6/2023 | -$7,750 |
| | 2024 | 2020 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG055480 | Cardiovascular Risk among Transgender Persons in a Regional Electronic Health Record Registry | 000 | 4 | NIH | 12/7/2023 | -$18,267 |
| | 2024 | 2020 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AG065914 | Neuronal activity modulation and age-related neurodegeneration | 001 | 1 | NIH | 11/22/2023 | -$90 |
| | 2024 | 2020 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AG065914 | Neuronal activity modulation and age-related neurodegeneration | 000 | 1 | NIH | 11/22/2023 | -$159 |
| | 2024 | 2020 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R03AG063235 | Pyroglutamate-modified Amyloid-B protein as a marker for future cognitive decline in preclinical Alzheimer?s disease | 000 | 2 | NIH | 12/7/2023 | -$7,339 |
| | 2024 | 2020 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS092730 | Chronic physiologic and behavior changes induced by novel STN DBS patterns for PD | 000 | 6 | NIH | 11/30/2023 | -$14 |
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| Issue Date FY: 2023 ( Subtotal = $134,701,113 ) (Continued on the next page) |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL164516 | Mechanisms of cancer immunotherapy-associated thrombosis | 001 | 1 | NIH | 5/22/2023 | -$721,398 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG082118 | Characterize neuronal and glial cell-specific vulnerability to proteinopathies in Alzheimer's disease using multimodal single-nuclei genomic and epigenomic approaches | 000 | 1 | NIH | 8/23/2023 | $811,605 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | U54CA274513 | Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies | 004 | 2 | NIH | 8/2/2023 | $66,643 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | DP2AI170515 | Developing a renewable and dissectible human liver for the study of HBV/HCV infection | 000 | 2 | NIH | 7/13/2023 | $483,000 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI171201 | Reassortment of Bunyavirus in ticks and animal models | 000 | 2 | NIH | 7/24/2023 | $577,846 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AR078498 | The proteolytic landscape of osteoarthritic cartilage | 000 | 2 | NIH | 4/12/2023 | $177,100 |
| | 2023 | 2023 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | 9500 EUCLID AVE | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS124081 | lncRNA regulation of glioblastoma progression and therapeutic resistance | 001 | 2 | NIH | 1/31/2023 | $54,720 |
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