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 | Issue Date FY: 2025 ( Subtotal = $41,840,826 ) (Continued on the next page) |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31CA284668 | Ribonucleotide Reductase as a Driver of Breast Cancer Aggressiveness | 000 | 2 | NIH | 4/24/2025 | $48,684 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG070736 | CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease | 000 | 5 | NIH | 1/8/2025 | $349,512 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R00DE031372 | Role of sulfide in oral microbiota-host interactions that promote periodontitis | 000 | 4 | NIH | 10/25/2024 | $249,000 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG070736 | CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease | 000 | 5 | NIH | 1/8/2025 | $1,006,459 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31AI174784 | Host and microbe-dependent mechanisms of enhanced autoimmune susceptibility driven by checkpoint inhibitors | 000 | 2 | NIH | 12/17/2024 | $53,974 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21CA288673 | Forging a new path with cyclin-dependent kinase inhibitors to treat epithelioid hemangioendothelioma | 000 | 2 | NIH | 1/23/2025 | $169,353 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL169427 | Developing hemophilia A therapeutics by targeting translational and posttranslational regulation of FVIII | 000 | 2 | NIH | 2/19/2025 | $466,266 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK126772 | Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine | 001 | 5 | NIH | 5/19/2025 | $48,126 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK126772 | Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine | 000 | 5 | NIH | 12/12/2024 | $433,135 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL169290 | Nutrition, terminal NAD metabolites and cardiovascular disease | 000 | 2 | NIH | 4/3/2025 | $705,896 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL166544 | The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumonia | 000 | 2 | NIH | 3/17/2025 | $507,150 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01EY032459 | Molecular Mechanisms of TULP1-Mediated Photoreceptor Degeneration | 000 | 4 | NIH | 4/7/2025 | $402,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS130798 | Sema3C Signaling as an Alternative Activator of Canonical Wnt Signaling in Glioblastoma | 000 | 3 | NIH | 4/9/2025 | $402,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK135265 | Mechanisms of Kidney Diseases Associated With APOL1 Variation | 000 | 3 | NIH | 12/31/2024 | $615,838 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI040459 | Post-Transplant Inflammatory Response | 002 | 26 | NIH | 5/1/2025 | $0 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI040459 | Post-Transplant Inflammatory Response | 000 | 26 | NIH | 11/15/2024 | $505,876 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS127374 | Hydrogen sulfide functions as a tumor suppressor in glioblastoma | 000 | 3 | NIH | 4/16/2025 | $515,147 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL164516 | Mechanisms of cancer immunotherapy-associated thrombosis | 000 | 3 | NIH | 3/27/2025 | $648,664 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35GM149240 | Immune Function in Sepsis: Role of Sirtuin | 001 | 3 | NIH | 2/20/2025 | $362,250 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DK131550 | Novel cytoskeletal mechanisms of pathogenic bacteria interactions with intestinal epithelium | 000 | 4 | NIH | 4/16/2025 | $506,825 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08HL159236 | Developing a Donor-Candidate Risk Prediction System to Optimize Lung Allocation and Transplant Outcomes | 000 | 4 | NIH | 4/1/2025 | $151,077 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG092591 | A Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer’s Disease and Longevity | 000 | 1 | NIH | 5/21/2025 | $802,034 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31CA290723 | SMARCA5 Inhibition as a Therapeutic Target for Glioblastoma | 000 | 1 | NIH | 5/1/2025 | $41,312 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31NS141426 | Investigating the role of sulfide oxidation and declining hydrogen sulfide in glioblastoma | 000 | 1 | NIH | 5/21/2025 | $42,574 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL179780 | Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease | 000 | 1 | NIH | 4/25/2025 | $743,302 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL173543 | Mitochondria in cardiomyocyte-fibroblast transcellular cross-talk | 000 | 1 | NIH | 5/12/2025 | $639,621 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI150931 | Manipulation of host factors that promote HCMV latency | 000 | 5 | NIH | 4/1/2025 | $477,589 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AI153173 | Uncovering aryl polyene biology to identify new drug targets in Gram-negative bacterial pathogens | 000 | 5 | NIH | 4/7/2025 | $402,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08AA028794 | Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease | 000 | 5 | NIH | 4/24/2025 | $179,129 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08DK137042 | Deep Learning of Renal Scans and Kidney Ultrasounds in Children with Antenatal Hydronephrosis | 000 | 1 | NIH | 3/4/2025 | $155,011 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R00EY033909 | The role of neuronal activity on retinal angiogenesis and blood-retina barrier (BRB) maturation | 000 | 3 | NIH | 4/23/2025 | $248,999 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL172805 | Artificial sweeteners and cardiovascular disease | 000 | 1 | NIH | 3/4/2025 | $796,395 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01GM121428 | The effect of nucleosomes on the earliest stages of RNA polymerase II transcription | 002 | 6 | NIH | 5/14/2025 | $373,119 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01NS136997 | Neural Coding and Control of Pain Detection in Somatosensory Cortex | 000 | 1 | NIH | 3/28/2025 | $560,934 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K23AT012484 | A Daily, Digital Mindfulness-Based Intervention for Depressive Symptoms After Serious Illness | 000 | 1 | NIH | 3/24/2025 | $165,240 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R37CA300540 | Assessing feasibility of gastric cancer screening in the US | 000 | 1 | NIH | 3/20/2025 | $564,414 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01HL058758 | Molecular basis of ILK-mediated cell adhesion | 002 | 24 | NIH | 3/20/2025 | $495,369 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01EY034755 | Inflammatory Signaling and Regeneration in Zebrafish models of Retinal Degeneration | 000 | 3 | NIH | 1/24/2025 | $515,193 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R03EB034863 | Development of motion correction algorithms for functional MRI data using a custom simultaneously excited multi-slice MRI acquisition with prospectively injected motion | 000 | 1 | NIH | 1/21/2025 | $80,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | F31EY035133 | Characterizing the role of mitochondrial DNA mutations on retinal degeneration. | 000 | 2 | NIH | 1/14/2025 | $48,974 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K08HL168348 | Nocturnal hypoxemia dysregulates skeletal muscle protein homeostasis in COPD | 000 | 1 | NIH | 12/24/2024 | $151,578 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | K23HL150279 | Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric Analyses | 000 | 5 | NIH | 1/28/2025 | $159,163 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01AG086247 | Improving colorectal cancer screening decisions through consideration of life expectancy | 000 | 1 | NIH | 12/31/2024 | $625,452 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R35GM156762 | Synthetic biology tools and strategies to streamline the sensing and responding to disease cues in engineered theragnostic bacteria. | 000 | 1 | NIH | 12/26/2024 | $402,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01MH133584 | Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors | 001 | 1 | NIH | 4/21/2025 | $353,125 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01MH133584 | Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors | 000 | 1 | NIH | 12/13/2024 | $241,500 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R21AI182702 | Modulation of Monocyte and T Cell Functions by Immune Inhibitory Receptors during Subclinical Malaria | 000 | 1 | NIH | 12/19/2024 | $184,109 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE033391 | Molecular mechanism of Zika virus-induced premature craniofacial suture closure | 001 | 2 | NIH | 5/5/2025 | $40,250 |
| | 2025 | 2025 | CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY | 9500 EUCLID AVE. | CLEVELAND | OH | 44195-0001 | CUYAHOGA | USA | R01DE033391 | Molecular mechanism of Zika virus-induced premature craniofacial suture closure | 000 | 2 | NIH | 12/17/2024 | $362,250 |
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