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Phylogenetic modeling of viral transmission dynamics at the human-wildlife interface in Uganda

Award Number: R01TW012704
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Phylogenetic modeling of viral transmission dynamics at the human-wildlife interface in Uganda - Modified Project Summary/Abstract Section Emerging infectious disease (EID) outbreaks in humans are increasing in frequency and are often the result of zoonotic transmission due to interactions with other animals, particularly in areas of Africa and Southeast Asia where recent global outbreaks have originated. Many nations in these areas lack the surveillance infrastructure necessary to detect and prevent the spread of EIDs, creating a major health challenge that threatens the safety and prosperity of the United States of America. Due to the lack of proactive surveillance, emerging zoonotic diseases are largely identified passively, only after an outbreak in humans, resulting in unnecessary suffering and economic costs. The spread of SARS-CoV-2 serves as a strong example of the costs of this passive monitoring approach. EID threats would be better managed with increased surveillance of systems where zoonotic disease transmission is likely and of species likely to harbor pathogens of concern. Understanding transmission in these systems and the factors that impact infection patterns can help inform mitigation strategies and allow us to understand these pathogens before they become a threat to our nation's health and security. Of particular concern are viruses, which disproportionately make up the zoonotic pathogens that result in human transmission and worldwide dissemination. To protect the U.S. from potential future EID threats, we will study an ecosystem in which wildlife are known to carry viruses of concern to human health and interact closely with people living nearby. Our project focuses on red colobus monkeys in Kibale National Park, Uganda, and the people who live around the boundary of the park who are the first line of exposure to zoonotic pathogens from wildlife in the forest. Red colobus monkeys are carriers for a variety of virus types that are known to cause widespread outbreaks in humans (e.g. pox viruses, Ebola). Overlap has been shown between pathogens infecting red colobus and people in these communities. After transmission to people, these viruses can spread around the world, including to the U.S.A. either directly or indirectly, threatening the health and safety of people here. American tourists and service members stationed overseas are also at risk of exposure to these diseases when they travel. These conditions present an opportunity to conduct research in Uganda where red colobus live and where people are exposed to zoonotic pathogens that are known to threaten human health. We will define the viromes of red colobus and humans living in close proximity to the red colobus and develop models to understand patterns of virus transmission both within and between red colobus and human communities. Our main goal is to understand factors that impact transmission dynamics between wild animals and humans and how to interrupt these transmission patterns. Importantly, principles discovered in this study could potentially be more broadly generalizable to understanding virus transmission from any animals to humans in any part of the globe. In this way, the project will promote the health and safety of people in the U.S.A.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $500,002 )
2026	2026	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	International Research and Research Training	002	4	9/10/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$500,002
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	000	3	8/13/2026	NON-COMPETING CONTINUATION	$0
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	001	3	9/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $500,002

Issue Date FY: 2025 ( Subtotal = $685,413 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	001	3	9/15/2025	NON-COMPETING CONTINUATION	$185,412
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	000	3	8/13/2025	NON-COMPETING CONTINUATION	$500,001
														Subtotal = $685,413

Issue Date FY: 2024 ( Subtotal = $667,311 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	International Research and Research Training	002	2	9/16/2024	NON-COMPETING CONTINUATION	$167,311
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	International Research and Research Training	001	2	5/30/2024	NON-COMPETING CONTINUATION	$500,000
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	International Research and Research Training	000	1	5/24/2024	NEW	$0
														Subtotal = $667,311

Issue Date FY: 2023 ( Subtotal = $540,590 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	000	1	7/24/2023	NEW	$540,590
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	International Research and Research Training	001	1	8/7/2023	NEW	$0
														Subtotal = $540,590

Grand Total All Awards = $2,393,316

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Phylogenetic modeling of viral transmission dynamics at the human-wildlife interface in Uganda

Award Number: R01TW012704

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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