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Land Use Change, Transmission Potential Networks and Disease Spread in Madagascar

Award Number: R01TW011493
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/17/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Land Use Change, Transmission Potential Networks and Disease Spread in Madagascar - Anthropogenic land use alters ecological communities, leading to the question: How do these changes alter infectious disease transmission, including to humans? This question is especially important in low-income countries such as Madagascar, where zoonotic diseases remain major threats to public health. The proposed research aims to model the ecological and socioeconomic factors that influence disease spread and predict how infectious agents spread from small mammals and domesticated animals to people. This goal will be pursued through innovative and interdisciplinary field, laboratory, and analytical approaches. The team of ecologists, social scientists, and a mathematician will integrate and model ecological and socioeconomic data from the field site in rural Madagascar, which includes a protected area surrounded by native forest fragments, agricultural fields, and villages of subsistence agriculturalists. Around four villages and in the park, the team will investigate multiple hypotheses concerning how human land use activities shape zoonotic disease transmission. To extend the findings globally, the researchers will use the Global Mammal Parasite Database to investigate how human land use and network connectivity impact host-parasite relationships and prevalence. The interdisciplinary team is uniquely positioned to investigate infectious disease transmission in this system. By integrating multiple data sources into unified mathematical representations, the team will investigate specific hypotheses for how diseases spread using multilayer transmission potential networks (TPNs). Significantly, they will test how TPNs and disease transmission change with human activities and identify the socioeconomic factors that lead some people to be more connected into transmission networks. Specifically, the team will: (i) identify pathways of disease transmission using cutting-edge field and analytical methods, coupled with infectious disease data representing multiple transmission modes; (ii) investigate socioeconomic characteristics of individual humans that most strongly connect them into TPNs of wildlife and domesticated animals; (iii) characterize how human activities generate entry points of infectious disease. Comparative analyses will extend the findings beyond the Malagasy study system. TPNs will be based on trapping data for small mammals, GPS data for people and domesticated animals, and social network surveys for people. The team will test whether these networks predict infection with multiple pathogens, including Leptospira, Yersinia, Babesia, Rickettsia, and gastrointestinal helminths. The research team has all necessary permits, extensive on-the-ground logistical support, and substantial pilot data on human and animal populations at the site.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$13,867 )
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	International Research and Research Training	000	5	9/11/2025	NON-COMPETING CONTINUATION	-$13,867
														Subtotal = -$13,867

Issue Date FY: 2023 ( Subtotal = $231,019 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	International Research and Research Training	000	5	4/4/2023	NON-COMPETING CONTINUATION	$231,019
														Subtotal = $231,019

Issue Date FY: 2022 ( Subtotal = $626,914 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	002	4	9/7/2022	SUPPLEMENT FOR EXPANSION	$75,792
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	004	4	9/13/2022	SUPPLEMENT FOR EXPANSION	$18,708
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	003	4	9/13/2022	SUPPLEMENT FOR EXPANSION	$75,792
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	001	4	4/14/2022	NON-COMPETING CONTINUATION	$456,622
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	000	3	10/21/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $626,914

Issue Date FY: 2021 ( Subtotal = $569,351 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	000	3	4/2/2021	NON-COMPETING CONTINUATION	$489,024
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	001	3	9/23/2021	SUPPLEMENT FOR EXPANSION	$80,327
														Subtotal = $569,351

Issue Date FY: 2020 ( Subtotal = $497,996 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	001	2	5/26/2020	NON-COMPETING CONTINUATION	$0
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	000	2	4/30/2020	NON-COMPETING CONTINUATION	$497,996
														Subtotal = $497,996

Issue Date FY: 2019 ( Subtotal = $710,151 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	International Research and Research Training	000	1	7/12/2019	NEW	$710,151
														Subtotal = $710,151

Grand Total All Awards = $2,621,564

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Land Use Change, Transmission Potential Networks and Disease Spread in Madagascar

Award Number: R01TW011493

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/17/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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