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Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions

Award Number: R01NS142815
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/16/2026
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions - Abstract/Project Summary As an essential component of most behaviors, the sympathetic system regulates many vital physiological processes, such as heart rate, blood pressure, and respiration. Sympathetic activities exhibit an arousal state- dependent basal level (tone), which is subject to behavioral context-dependent regulation (activation and inactivation). In contrast to its importance, much less is known about top-down sympathetic regulation. Our recent studies reveal several populations of spinal projecting neurons (SPNs) with the capacity to regulate sympathetic preganglionic neurons. We hypothesize that medullary and hypothalamic SPNs may form parallel circuits to control state-dependent sympathetic activities with or without accompanying motor engagement. The objective of this proposed study is to test this hypothesis by analyzing the fundamental circuit architectures of sympathetic controlling SPNs, and determining the roles of these SPNs in regulating the basal tone of sympathetic activity, as well as their response to exercise and pain. The outcomes of this study are expected to advance the fundamental knowledge about autonomic regulation and its health impact.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $674,950 )
2026	2026	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/15/2026	NEW	$674,950
														Subtotal = $674,950

Grand Total All Awards = $674,950

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Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions

Award Number: R01NS142815

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/16/2026

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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