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 | Issue Date FY: 2025 ( Subtotal = $270,235,691 ) (Continued on the next page) |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA287076 | Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity | 001 | 2 | NIH | 5/22/2025 | $73,306 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA287076 | Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity | 000 | 2 | NIH | 3/3/2025 | $659,763 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21DK142111 | Transformation of a human iPSC-derived bone marrow organoid for the study of hematopoiesis | 000 | 1 | NIH | 8/29/2025 | $469,042 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK143991 | Stress Granules in Red Blood Cell Development | 000 | 1 | NIH | 9/10/2025 | $801,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21AI180611 | C. albicans cell wall stress responses and TOR signaling | 000 | 1 | NIH | 7/28/2025 | $489,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01NS142013 | FAST-ET: Fast Automated Serial Tape-Enabled Electron Tomography | 000 | 1 | NIH | 7/31/2025 | $4,095,511 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL176663 | Investigating the pro-regenerative potential of Pontin in the heart. | 000 | 1 | NIH | 7/30/2025 | $833,594 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | RF1AG093462 | Genetics of exceptional resilience and its variation; insights from the world's longest-lived animal | 000 | 1 | NIH | 8/4/2025 | $1,875,196 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB037186 | Motion and distortion-robust quantitative MRI of early brain developments | 001 | 1 | NIH | 8/27/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB037186 | Motion and distortion-robust quantitative MRI of early brain developments | 000 | 1 | NIH | 7/29/2025 | $511,583 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL182042 | Developing a spatiotemporal lineage map of heart development | 000 | 1 | NIH | 7/24/2025 | $865,286 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182177 | Armed nanobodies as anti-infectives and anti-tumor agents | 001 | 2 | NIH | 5/23/2025 | $299,967 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DK127251 | Effect of Thickened Feeds on Swallow Physiology and Clinical Outcomes in Children with Brief Resolved Unexplained Event | 000 | 5 | NIH | 2/26/2025 | $194,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21AI185295 | Unravelling the role of aDb2 as a novel complement receptor in lung injury | 000 | 1 | NIH | 7/23/2025 | $489,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182177 | Armed nanobodies as anti-infectives and anti-tumor agents | 001 | 2 | NIH | 5/23/2025 | $242,933 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI169648 | Functional investigation of a novel and essential subcellular compartment in Plasmodium falciparum transmission stage parasites | 000 | 4 | NIH | 2/18/2025 | $687,521 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | RF1NS142871 | Transposable Element Mobilization and Disrupted Translational Machinery in Down Syndrome | 000 | 1 | NIH | 7/30/2025 | $1,274,904 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01NS142019 | Role of KMT2D in neurodevelopmental disorders | 000 | 1 | NIH | 8/6/2025 | $241,380 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21AI194232 | Human cellular models of TB and innate immunity | 000 | 1 | NIH | 7/23/2025 | $489,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R13AR086669 | Development of a Pediatric Rheumatology Common Data Element set (CDE) for Juvenile Idiopathic Arthritis | 000 | 1 | NIH | 7/24/2025 | $1 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R13AR086669 | Development of a Pediatric Rheumatology Common Data Element set (CDE) for Juvenile Idiopathic Arthritis | 000 | 1 | NIH | 7/24/2025 | $74,833 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21AI180552 | Structural studies of the full-length nucleocapsid protein of SARS-CoV-2 | 000 | 1 | NIH | 7/23/2025 | $489,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32GM159374 | Investigating BMAL1-RNA interactions and their roles in circadian rhythms | 001 | 1 | NIH | 7/25/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32GM159374 | Investigating BMAL1-RNA interactions and their roles in circadian rhythms | 000 | 1 | NIH | 7/25/2025 | $81,040 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD119283 | Neuroendocrine computations underlying an enduring behavioral state | 000 | 1 | NIH | 8/13/2025 | $571,485 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HS028930 | A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities | 000 | 4 | AHRQ | 2/10/2025 | $199,324 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R03AR085214 | Novel Modulators of Limb Development and Chondrocyte Maturation | 000 | 1 | NIH | 8/19/2025 | $177,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01AR085194 | Non-coding genetic risk variants modulating Tregs in arthritis | 000 | 1 | NIH | 8/18/2025 | $122,563 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21EB036775 | Ex vivo and In vivo Model Advancements for Airway Stent Design Optimization | 001 | 1 | NIH | 8/26/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21EB036775 | Ex vivo and In vivo Model Advancements for Airway Stent Design Optimization | 000 | 1 | NIH | 7/4/2025 | $222,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K00NS129126 | Epilepsy Mechanisms and the Path to Intervention | 001 | 3 | NIH | 9/24/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99AI187733 | Macrophage identity as a function of cell of origin | 000 | 1 | NIH | 8/21/2025 | $122,839 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K00NS129126 | Epilepsy Mechanisms and the Path to Intervention | 000 | 3 | NIH | 8/13/2025 | $85,752 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167513 | Targeting ZNF410 for HbF reactivation | 001 | 3 | NIH | 8/19/2025 | $67,241 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167513 | Targeting ZNF410 for HbF reactivation | 000 | 3 | NIH | 2/28/2025 | $605,162 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U19AI189176 | Immunization against Multidrug-resistant Pathogens: Activating T Cell Immunity (IMPACT-CETR) | 000 | 1 | NIH | 8/19/2025 | $4,776,780 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 001 | 2 | NIH | 8/21/2025 | -$74,261 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 000 | 2 | NIH | 3/12/2025 | $127,305 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32HL182158 | Additive Therapeutic Efficacy Of Pluripotent Stem Cell-Derived Cardiovascular Cells Engrafted In Hydrogels To Treat Ischemia-Reperfusion Injury After Myocardial Infarction | 001 | 1 | NIH | 8/15/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32HL182158 | Additive Therapeutic Efficacy Of Pluripotent Stem Cell-Derived Cardiovascular Cells Engrafted In Hydrogels To Treat Ischemia-Reperfusion Injury After Myocardial Infarction | 000 | 1 | NIH | 8/15/2025 | $88,434 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH130356 | Effects of 16p11.2 copy number variation on neuronal development and pathology | 000 | 3 | NIH | 2/19/2025 | $699,666 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL158192 | High resolution lineage tracing of developmental hematopoiesis | 000 | 3 | NIH | 3/6/2025 | $668,787 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL158192 | High resolution lineage tracing of developmental hematopoiesis | 001 | 3 | NIH | 7/16/2025 | $74,310 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI175556 | Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic Dermatitis | 000 | 3 | NIH | 2/12/2025 | $757,963 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R37NS109211 | Kinetochore Protein Functions in Synaptogenesis | 002 | 7 | NIH | 8/4/2025 | $619,447 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA295865 | Evaluating Pathways Involved in Melanoma Initiation | 000 | 1 | NIH | 7/29/2025 | $679,604 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI191995 | Phase 1 study of a SARS-CoV-2 vaccine adjuvanted via controlled biodistribution of mRNA encoding spike protein and IL-12p70 | 000 | 1 | NIH | 9/25/2025 | $1,673,641 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AG071858 | Integrated Platform to study Neurodegeneration in Alzheimer’s Disease | 000 | 5 | NIH | 3/10/2025 | $700,513 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AG071858 | Integrated Platform to study Neurodegeneration in Alzheimer’s Disease | 001 | 5 | NIH | 6/9/2025 | $62,267 |
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