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 | Issue Date FY: 2025 ( Subtotal = $61,181,440 ) (Continued on the next page) |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI189789 | Molecular mechanism of tetanus neurotoxin pathogenesis | 000 | 1 | NIH | 1/2/2025 | $808,216 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01GM148392 | CD11c as a novel target to improve neutrophil effector functions and sepsis outcome | 000 | 3 | NIH | 12/20/2024 | $343,785 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21CA296527 | Advanced Genetic Engineering to Unravel Tumor-Specific B Cell Responses | 000 | 1 | NIH | 12/20/2024 | $249,645 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB032708 | Fetal MRI: robust self-driving brain acquisition and body movement quantification | 000 | 4 | NIH | 11/26/2024 | $623,514 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F31HL178310 | Investigating cellular adaptation to one-carbon metabolism perturbation | 000 | 1 | NIH | 1/13/2025 | $38,987 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HS028930 | A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities | 000 | 4 | AHRQ | 2/10/2025 | $199,324 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DE033701 | Architecture and function of the neural crest genome | 000 | 2 | NIH | 1/27/2025 | $498,631 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK134647 | The Role of Tcf7l2 in maintaining liver zonation and metabolic homeostasis | 000 | 3 | NIH | 1/20/2025 | $474,063 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32HL172637 | Endothelial and mural cell interaction in capillary malformation | 000 | 2 | NIH | 12/5/2024 | $78,892 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F31NS141557 | Neuronal Primary Cilia Dysfunction in Tuberous Sclerosis Complex | 001 | 1 | NIH | 1/3/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R03DK142029 | Identification of isoform-specific WT1 interaction partners | 000 | 1 | NIH | 12/4/2024 | $133,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS121657 | Motion and Distortion Robust Diffusion Weighted Imaging Sequences for Pediatric Patients | 000 | 3 | NIH | 12/16/2024 | $398,250 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS121334 | Fetal Brain MRI as a Predictor of Late Neurodevelopmental Outcome in Congenital Heart Disease | 000 | 4 | NIH | 12/16/2024 | $426,716 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99DC022343 | Defining the role of MET components in vestibular hair cell maturation and gene therapy responsiveness | 000 | 1 | NIH | 12/17/2024 | $132,705 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99HG013991 | Deciphering Determinants of Somatic Evolution with Single-Cell Genealogy | 000 | 1 | NIH | 1/27/2025 | $126,830 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R37NS035129 | Human Epilepsy Genetics - Mosaic Mutations in Focal Epilepsy | 000 | 26 | NIH | 11/28/2024 | $910,212 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS124879 | Developmentally Programmed Remodeling of Apical ECM | 000 | 4 | NIH | 11/27/2024 | $393,522 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS140165 | Use-Dependent Adjustments to Dopamine Reception in Motivational Control | 000 | 1 | NIH | 11/28/2024 | $529,878 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K12HD052896 | Child Health Research Career Development Award (CHRCDA) Program (K12) | 001 | 18 | NIH | 3/6/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R35HL150876 | Cell-cell interactions governing lung epithelial progenitor cells | 000 | 6 | NIH | 3/27/2025 | $796,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA255216 | Non-invasive imaging of the anti-tumor immune response | 001 | 5 | NIH | 2/19/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DK127251 | Effect of Thickened Feeds on Swallow Physiology and Clinical Outcomes in Children with Brief Resolved Unexplained Event | 000 | 5 | NIH | 2/26/2025 | $194,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI125051 | Gene therapy for SCID-X1 with low dose busulfan and a SIN-lentiviral vector | 002 | 8 | NIH | 2/19/2025 | $894,481 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH130356 | Effects of 16p11.2 copy number variation on neuronal development and pathology | 000 | 3 | NIH | 2/19/2025 | $699,666 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH129636 | Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI? | 000 | 4 | NIH | 3/14/2025 | $659,667 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI181618 | HIV-1 membrane fusion and inhibition | 000 | 2 | NIH | 3/18/2025 | $752,675 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21NS135389 | Mitigating Post-Traumatic Epileptogenesis by Enhancing Synaptic Glutamate Transport via Long-Term Non-Bactericidal Beta-Lactam Administration | 000 | 2 | NIH | 3/18/2025 | $265,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083139 | Engineering self-assembled skin-on-a-chip | 001 | 2 | NIH | 3/13/2025 | $628,069 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R37NS035129 | Human Epilepsy Genetics - Mosaic Mutations in Focal Epilepsy | 001 | 26 | NIH | 3/20/2025 | -$26,722 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 000 | 2 | NIH | 3/12/2025 | $127,305 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01DK129409 | Mechanisms of Flow-driven Transcriptional Control of Hematopoietic Stem Cell Development by YAP | 000 | 5 | NIH | 3/28/2025 | $153,046 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY033025 | ECM Regulation of Ocular Surface Disease | 000 | 4 | NIH | 3/20/2025 | $442,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY031715 | G protein-coupled receptor regulation of transcriptional mechanisms in the retinal vasculature. | 000 | 5 | NIH | 3/20/2025 | $475,344 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U19AI168643 | Immune development in early life (IDEAL) shapes vaccine response, respiratory infectious diseaseand asthma | 001 | 4 | NIH | 3/19/2025 | $1,534,027 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K08DK125768 | Delineation of pathogenic mechanisms of NOS1AP and TRIM8 mutations in monogenic SRNS/FSGS. | 000 | 5 | NIH | 3/28/2025 | $167,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167723 | Sphingolipid signaling in the endothelium during viral host defense | 000 | 2 | NIH | 1/10/2025 | $623,678 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD110772 | Accurate, reliable, and interpretable machine learning for assessment of neonatal and pediatric brain micro-structure | 000 | 3 | NIH | 1/9/2025 | $342,495 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL152358 | Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHD | 000 | 5 | NIH | 2/15/2025 | $704,328 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AG070921 | Rates and mechanisms of age-related somatic mutation in normal and Alzheimer brain | 000 | 5 | NIH | 3/24/2025 | $743,704 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167513 | Targeting ZNF410 for HbF reactivation | 000 | 3 | NIH | 2/28/2025 | $605,162 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL171206 | Mechanistic dissection of 22q11.2DS in zebrafish | 000 | 2 | NIH | 2/28/2025 | $559,110 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K08HL173561 | Endothelial cell-based therapy for pulmonary vascular disease using induced pluripotent stem cells | 000 | 2 | NIH | 2/28/2025 | $167,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R00NS126725 | Dissecting Hypothalamic Pathways for Seizure Control | 000 | 4 | NIH | 2/14/2025 | $224,098 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K08NS130150 | The Role of Fos and the BAF Complex in Neuronal Activity-Dependent Chromatin Remodeling and Gene Expression | 000 | 3 | NIH | 3/24/2025 | $192,020 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL151494 | The Biogenesis of Platelet-Derived Extracellular Vesicles and their Impact on Megakaryocyte Maturation | 000 | 5 | NIH | 3/10/2025 | $519,546 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA287076 | Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity | 000 | 2 | NIH | 3/3/2025 | $659,763 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R35HL166556 | Inflammation and thrombosis fuel cardiovascular and pulmonary disease: Focus on the interplay of neutrophil inflammasomes with NETs | 000 | 3 | NIH | 3/10/2025 | $1,115,101 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32MD017452 | Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation | 001 | 3 | NIH | 3/22/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL159714 | Latent TGF-β2 Structure and Activation | 000 | 9 | NIH | 3/4/2025 | $635,818 |
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