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 | Issue Date FY: 2025 ( Subtotal = $100,560,961 ) (Continued on the next page) |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99AR083482 | Elucidating the neuroimmune mechanisms underlying pain and inflammation in autoimmune arthritis (Admin Supplement) | 000 | 1 | NIH | 4/4/2025 | $75,600 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL150106 | Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activation | 000 | 5 | NIH | 12/13/2024 | $398,250 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R37AI116550 | Defining the pathways activated by Toll-like Receptors to stimulate immunity | 001 | 9 | NIH | 1/7/2025 | $531,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167723 | Sphingolipid signaling in the endothelium during viral host defense | 000 | 2 | NIH | 1/10/2025 | $623,678 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY036071 | Signal Generation and Processing in the Retinohypothalamic Pathway | 000 | 2 | NIH | 4/21/2025 | $701,343 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32NS136267 | Leveraging Choroid Plexus M-CSF Signaling to Prevent Inflammatory-Driven Hydrocephalus | 000 | 2 | NIH | 4/22/2025 | $79,756 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB034757 | Low-dose contrast enhanced fast pediatric brain MRI | 000 | 2 | NIH | 3/24/2025 | $536,405 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL152063 | Single cell, whole genome analysis of the aging human cardiomyocyte | 000 | 5 | NIH | 12/19/2024 | $741,911 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01HL171354 | Associations between Perfluoroalkyl Substances (PFAS) Exposure and Aeroallergen Sensitization among Infants at High-Risk for Developing Asthma | 000 | 2 | NIH | 11/21/2024 | $161,316 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA282477 | Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF | 000 | 2 | NIH | 4/28/2025 | $630,260 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD076258 | Neonatal Hypoxic Ischemic Encephalopathy: Potential of Innovative NIRS to Optimize Hypothermia | 000 | 9 | NIH | 5/2/2025 | $758,755 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL161605 | Glypicans in Bacterial Lung Infection | 000 | 2 | NIH | 4/8/2025 | $561,477 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY036220 | Promoting myelination of regenerating axons for vision restoration | 000 | 2 | NIH | 4/10/2025 | $560,851 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI178865 | Spatial, temporal, and functional study of the basal complex in Plasmodium falciparum | 000 | 2 | NIH | 1/15/2025 | $691,974 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD107060 | Inflammatory stressors in serotonergic brainstem dysfunction and SIDS | 000 | 3 | NIH | 4/2/2025 | $723,152 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK115217 | Type III interferon Control of Mucosal Immunity | 000 | 7 | NIH | 12/30/2024 | $699,678 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS133228 | Improved 3D EPI for Pre-Surgical Mapping of Epilepsy | 000 | 2 | NIH | 5/13/2025 | $534,141 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | P01AI089618 | Structure-function analysis of infection- and vaccine-induced B-cell repertoires | 000 | 13 | NIH | 4/18/2025 | $2,950,624 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS131098 | eCD4-Mediated Control of SIV Infection in the Brain | 000 | 3 | NIH | 4/30/2025 | $830,924 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HG012871 | An ensemble framework for regulatory variant prediction. | 001 | 3 | NIH | 4/28/2025 | $51,542 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HG012871 | An ensemble framework for regulatory variant prediction. | 000 | 3 | NIH | 4/7/2025 | $463,882 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01DA057374 | Mobile health applications in adolescent marijuana use: assessing the interplay among sleep, pain and inhibitory control | 000 | 3 | NIH | 1/8/2025 | $189,363 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AG078423 | Shared Genetic and Environmental Influences on Age-Related Hearing Loss, Cognitive Decline, and Dementia Risk | 000 | 3 | NIH | 4/4/2025 | $656,205 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI170632 | Macrophage immunometabolism controls septic shock | 000 | 3 | NIH | 4/25/2025 | $639,636 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS107490 | Axonal Transport of mRNA for Mitochondrial Proteins | 001 | 7 | NIH | 4/9/2025 | $578,845 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL163937 | CMYA5 regulation of cardiac dyad structure and function | 000 | 3 | NIH | 11/11/2024 | $541,964 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 000 | 2 | NIH | 12/11/2024 | $463,780 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK128455 | HSPG Interactions in Liver Disease | 000 | 4 | NIH | 4/17/2025 | $451,079 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R35HL166556 | Inflammation and thrombosis fuel cardiovascular and pulmonary disease: Focus on the interplay of neutrophil inflammasomes with NETs | 000 | 3 | NIH | 3/10/2025 | $1,115,101 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL164710 | The role N-terminal acetylation in dilated cardiomyopathy and associated arrhythmia | 000 | 3 | NIH | 5/9/2025 | $752,579 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DA055916 | Use of Digital Phenotyping to Understand Digital Media Influence on Adolescent Substance Use | 000 | 3 | NIH | 4/18/2025 | $194,891 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL159714 | Latent TGF-β2 Structure and Activation | 000 | 9 | NIH | 3/4/2025 | $635,818 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167513 | Targeting ZNF410 for HbF reactivation | 000 | 3 | NIH | 2/28/2025 | $605,162 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI175556 | Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic Dermatitis | 000 | 3 | NIH | 2/12/2025 | $757,963 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL158192 | High resolution lineage tracing of developmental hematopoiesis | 000 | 3 | NIH | 3/6/2025 | $668,787 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH130356 | Effects of 16p11.2 copy number variation on neuronal development and pathology | 000 | 3 | NIH | 2/19/2025 | $699,666 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 000 | 2 | NIH | 3/12/2025 | $127,305 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HS028930 | A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities | 000 | 4 | AHRQ | 2/10/2025 | $199,324 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DK127251 | Effect of Thickened Feeds on Swallow Physiology and Clinical Outcomes in Children with Brief Resolved Unexplained Event | 000 | 5 | NIH | 2/26/2025 | $194,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI112652 | Global regulators converge to orchestrate metabolism, biofilm, and pathogenesis | 000 | 9 | NIH | 2/13/2025 | $577,362 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI169648 | Functional investigation of a novel and essential subcellular compartment in Plasmodium falciparum transmission stage parasites | 000 | 4 | NIH | 2/18/2025 | $687,521 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL155632 | Transcription Factor 4 Maintain Endothelial identity to Oppose Heart Failure | 000 | 4 | NIH | 11/19/2024 | $451,532 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01GM148392 | CD11c as a novel target to improve neutrophil effector functions and sepsis outcome | 000 | 3 | NIH | 12/20/2024 | $343,785 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167925 | Simple and Effective Laceration of Potentially-calcified Leaflets as an Adjunct to Transcatheter Valve Replacement | 000 | 2 | NIH | 12/13/2024 | $718,215 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI179563 | Controlling and Preventing Asthma Progression and Severity in Kids with Omalizumab Extension (PARK-EXT) | 000 | 2 | NIH | 5/12/2025 | $2,250,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK138023 | Leveraging glycan-metabolite interactions to shape structure and function of the gut microbiome | 000 | 2 | NIH | 4/16/2025 | $644,539 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD114338 | Developing novel MR tools to optimize surgical planning and fetal outcome in TTTS | 000 | 2 | NIH | 4/2/2025 | $717,249 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB032708 | Fetal MRI: robust self-driving brain acquisition and body movement quantification | 000 | 4 | NIH | 11/26/2024 | $623,514 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32MD017452 | Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation | 001 | 3 | NIH | 3/22/2025 | $0 |
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