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 | Issue Date FY: 2025 ( Subtotal = $148,227,751 ) (Continued on the next page) |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA287076 | Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity | 000 | 2 | NIH | 3/3/2025 | $659,763 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R61NS130215 | Development and Validation of a Nocturnal Sleep Signature for the Diagnosis of Idiopathic Hypersomnia | 000 | 2 | NIH | 5/20/2025 | $731,511 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R61NS130215 | Development and Validation of a Nocturnal Sleep Signature for the Diagnosis of Idiopathic Hypersomnia | 001 | 2 | NIH | 5/29/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99HG013991 | Deciphering Determinants of Somatic Evolution with Single-Cell Genealogy | 000 | 1 | NIH | 1/27/2025 | $126,830 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DA056771 | Engineering CAR-B cells for an HIV-1 functional cure | 002 | 4 | NIH | 6/27/2025 | $686,549 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U19AI158076 | Attacking failure of antibiotic treatment by targeting antimicrobial resistance enabler cell-states | 003 | 4 | NIH | 6/27/2025 | $2,470,464 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DE033701 | Architecture and function of the neural crest genome | 001 | 2 | NIH | 5/7/2025 | $55,404 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DE033701 | Architecture and function of the neural crest genome | 000 | 2 | NIH | 1/27/2025 | $498,631 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 002 | 2 | NIH | 6/9/2025 | $36,071 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 001 | 2 | NIH | 6/4/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 000 | 2 | NIH | 12/11/2024 | $463,780 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI181964 | Consortium for food allergy research clinical center CoFar | 000 | 2 | NIH | 4/1/2025 | $380,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI160087 | Novel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s Hospital | 000 | 5 | NIH | 4/11/2025 | $1 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL172489 | In vivo hematopoietic stem cell genetic modification by viral particles | 000 | 2 | NIH | 5/23/2025 | $874,907 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | UM1HL172702 | Pediatric Heart Network Clinical Research Centers - Boston Children's Hospital | 000 | 2 | NIH | 12/25/2024 | $448,031 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R35GM151000 | Understanding Immune-Stromal Interactions in Tissue Homeostasis and Inflammation | 000 | 3 | NIH | 5/22/2025 | $442,500 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | RC2DK131963 | Generation of a temporal, spatial, and molecular map of in situ hematopoiesis | 000 | 4 | NIH | 6/27/2025 | $964,223 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167925 | Simple and Effective Laceration of Potentially-calcified Leaflets as an Adjunct to Transcatheter Valve Replacement | 000 | 2 | NIH | 12/13/2024 | $718,215 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI179563 | Controlling and Preventing Asthma Progression and Severity in Kids with Omalizumab Extension (PARK-EXT) | 000 | 2 | NIH | 5/12/2025 | $2,250,000 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD114338 | Developing novel MR tools to optimize surgical planning and fetal outcome in TTTS | 000 | 2 | NIH | 4/2/2025 | $717,249 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS138758 | Molecular Pathways that Strengthen GABAergic Inhibition and Reduce Seizure Susceptibility | 000 | 2 | NIH | 6/10/2025 | $515,889 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI186793 | An Env apex-focused HIV-1 vaccine strategy | 000 | 2 | NIH | 5/15/2025 | $867,099 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99HD115830 | Neural Markers of Developmental Delays in Premature and Full Term Infants | 000 | 2 | NIH | 5/6/2025 | $132,705 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32MD017452 | Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation | 001 | 3 | NIH | 3/22/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32MD017452 | Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation | 000 | 3 | NIH | 11/10/2024 | $78,784 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB032708 | Fetal MRI: robust self-driving brain acquisition and body movement quantification | 001 | 4 | NIH | 5/19/2025 | $69,278 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EB032708 | Fetal MRI: robust self-driving brain acquisition and body movement quantification | 000 | 4 | NIH | 11/26/2024 | $623,514 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL155632 | Transcription Factor 4 Maintain Endothelial identity to Oppose Heart Failure | 000 | 4 | NIH | 11/19/2024 | $451,532 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01GM148392 | CD11c as a novel target to improve neutrophil effector functions and sepsis outcome | 000 | 3 | NIH | 12/20/2024 | $343,785 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK138023 | Leveraging glycan-metabolite interactions to shape structure and function of the gut microbiome | 000 | 2 | NIH | 4/16/2025 | $644,539 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI180137 | Mechanism of the transcription factor FoxP3 in regulatory T cell development | 001 | 2 | NIH | 6/25/2025 | $0 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI180137 | Mechanism of the transcription factor FoxP3 in regulatory T cell development | 000 | 2 | NIH | 10/24/2024 | $772,604 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY032539 | Molecular mechanisms underlying strabismus risk | 000 | 4 | NIH | 12/19/2024 | $642,268 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HS028930 | A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities | 000 | 4 | AHRQ | 2/10/2025 | $199,324 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 000 | 2 | NIH | 3/12/2025 | $127,305 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167513 | Targeting ZNF410 for HbF reactivation | 000 | 3 | NIH | 2/28/2025 | $605,162 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH130356 | Effects of 16p11.2 copy number variation on neuronal development and pathology | 000 | 3 | NIH | 2/19/2025 | $699,666 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL158192 | High resolution lineage tracing of developmental hematopoiesis | 000 | 3 | NIH | 3/6/2025 | $668,787 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI175556 | Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic Dermatitis | 000 | 3 | NIH | 2/12/2025 | $757,963 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI169648 | Functional investigation of a novel and essential subcellular compartment in Plasmodium falciparum transmission stage parasites | 000 | 4 | NIH | 2/18/2025 | $687,521 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DK127251 | Effect of Thickened Feeds on Swallow Physiology and Clinical Outcomes in Children with Brief Resolved Unexplained Event | 000 | 5 | NIH | 2/26/2025 | $194,940 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182177 | Armed nanobodies as anti-infectives and anti-tumor agents | 001 | 2 | NIH | 5/23/2025 | $299,967 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182177 | Armed nanobodies as anti-infectives and anti-tumor agents | 001 | 2 | NIH | 5/23/2025 | $242,933 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI112652 | Global regulators converge to orchestrate metabolism, biofilm, and pathogenesis | 000 | 9 | NIH | 2/13/2025 | $577,362 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI181618 | HIV-1 membrane fusion and inhibition | 000 | 2 | NIH | 3/18/2025 | $752,675 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | T32HD098061 | Neonatal Research Training Program | 004 | 7 | NIH | 5/30/2025 | $686 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | T32HD098061 | Neonatal Research Training Program | 003 | 7 | NIH | 5/29/2025 | $8,568 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | T32HD098061 | Neonatal Research Training Program | 002 | 7 | NIH | 4/11/2025 | $591,193 |
| | 2025 | 2025 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01MH129636 | Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI? | 000 | 4 | NIH | 3/14/2025 | $659,667 |
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