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Neural Coding and Control of Pain Detection in Somatosensory Cortex

Award Number: R01NS136997
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2025
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Neural Coding and Control of Pain Detection in Somatosensory Cortex - Summary/Abstract We propose to: Aim 1) Deﬁne the temporal patterns and characterizing the LFP properties of S1 oscillations in relation to pain in healthy and chronic pain conditions using novel behavioral assay; Aim 2) Correlate LFP oscillations to underlying neural activity in S1 at the spiking level using NeuroPixels; Aim 3) Identify neural sub- circuits in S1 using genetically-encoded voltage indicators during nociceptive behavior and investigate the functional signiﬁcance of S1 neurons to nociceptive behavior. These aims will be achieved in mice using state- of-the-art techniques for electrophysiological recordings of LFP and spiking activity in single units with genetically-encoded voltage indicators in vivo combined with optogenetic interventions during sub-second behavioral paradigms, therefore, this application will enhance our scientiﬁc understanding of pain mechanisms in the brain and potentially lead to novel diagnostic and therapeutic approaches to better manage pain in the clinical setting.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $560,934 )
2025	2025	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/28/2025	NEW	$560,934
														Subtotal = $560,934

Grand Total All Awards = $560,934

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Neural Coding and Control of Pain Detection in Somatosensory Cortex

Award Number: R01NS136997

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2025

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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