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Investigating the relationship between Sympathetic Nervous System Development and Neuroblastoma

Award Number: R01NS128108
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Investigating the relationship between Sympathetic Nervous System Development and Neuroblastoma - Project Summary A common feature of embryonic development is that cells are born in one place and have to move as a cluster and regulate their differentiation before connecting with a vital target in a different location. One result of this dynamic morphogenetic event is assembly of the sympathetic nervous system that is essential for maintaining blood pressure, heart rate, and temperature control with improper development leading to birth defects and neuroblastoma cancer in infants. We are interested in understanding how the signals that regulate the collective cell movement and differentiation of the embryonic neural crest cells are orchestrated, spatially and temporally, to drive the emergence of the patterned sympathetic nervous system. To address this, we will implement an innovative combination of techniques from biological, in vivo imaging and single cell spatial transcriptomic sciences applied to the avian model system, most of which are not currently possible but may be translated to developing mammalian systems. This study will be significant because it will identify the signals involved in sympathetic nervous system development, linking the central and peripheral nervous systems -- with special focus on the role of TrkB and on determining the signals that mediate the migration, differentiation, survival, and molecular crosstalk between neural crest cells that ensure sympathetic nervous system circuit formation. The results of this study will provide critical information for surgical methods to correct by neural repair and mitigate the effects of sympathetic nervous system birth defects and translate into and inform improved drug design efforts targeting receptor tyrosine kinase signaling as a treatment for neuroblastoma and possible increase in infant survival.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/21/2025	NEW	-$1
2025	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	2/21/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $6,251 )
2024	2023	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/29/2024	NEW	-$391,249
2024	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/29/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$397,500
														Subtotal = $6,251

Issue Date FY: 2023 ( Subtotal = $391,250 )
2023	2023	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/30/2023	NEW	$391,250
														Subtotal = $391,250

Grand Total All Awards = $397,501

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Investigating the relationship between Sympathetic Nervous System Development and Neuroblastoma

Award Number: R01NS128108

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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