Tuesday, February 10, 2026 2/10/2026

Role of Selective Autophagy of Focal Adhesion in Intracranial Aneurysm

Award Number: R01NS126820
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Role of Selective Autophagy of Focal Adhesion in Intracranial Aneurysm - PROJECT SUMMARY An intracranial aneurysm (IA) is a bulge or ballooning of the cerebral artery due to weakness in the blood vessel wall. IA rupture causes subarachnoid hemorrhage (SAH), the most life-threatening form of stroke. However, the molecular mechanisms underlying IA pathogenesis are poorly understood, which greatly impedes the identification of therapeutic targets. To date, no pharmacological treatment is available for IA except for invasive surgical options, such as surgical clipping and endovascular coiling, both of which are generally associated with high hospitalization costs. Our long-term goal is to elucidate the molecular mechanisms of IA and develop new therapeutic avenues for this devastating disease. The overall objective in this application is to determine the role of selective autophagy of endothelial focal adhesion (FA) in cerebrovascular integrity and IA formation and progression. The central hypothesis is that p62- VASP interaction is a critical cargo recognition mechanism for selective autophagy of FA (FA-phagy) in endothelial cells, which impairs cerebrovascular integrity and contributes to IA formation and progression. The central hypothesis will be tested in two specific aims: 1) dissect the molecular mechanisms of FA- phagy in endothelial cells; and 2) determine the role of endothelial FA-phagy in cerebrovascular integrity and IA formation and progression. Our proposal is innovative, because we are the first to identify p62- VASP interaction as a novel cargo recognition mechanism for endothelial FA-phagy, and provide endothelial FA-phagy as a novel pathogenic mechanism for IA. The proposed research is significant because we connect selective autophagy to cerebrovascular integrity, which will not only add cutting- edge knowledge to the selective autophagy field but also provide anti-FA-phagy strategy as a novel therapy for IA disease or potentially for many other diseases that exhibit the loss of vascular integrity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $343,906 )
2026	2026	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/23/2025	NON-COMPETING CONTINUATION	$343,906
														Subtotal = $343,906

Issue Date FY: 2025 ( Subtotal = $343,906 )
2025	2025	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/26/2024	NON-COMPETING CONTINUATION	$343,906
														Subtotal = $343,906

Issue Date FY: 2024 ( Subtotal = $370,651 )
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/13/2023	NON-COMPETING CONTINUATION	$343,906
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/3/2024	NON-COMPETING CONTINUATION	$26,745
														Subtotal = $370,651

Issue Date FY: 2023 ( Subtotal = $382,114 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON, THE	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/10/2023	NEW	$382,114
														Subtotal = $382,114

Grand Total All Awards = $1,440,577

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Role of Selective Autophagy of Focal Adhesion in Intracranial Aneurysm

Award Number: R01NS126820

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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