Wednesday, December 31, 2025 12/31/2025

The relationship between neuronal activity and stroke

Award Number: R01NS126526
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2022
PERIOD OF PERFORMANCE END DATE: 11/30/2027

Group Awards By:

View Award Description

The relationship between neuronal activity and stroke - Stroke is the one of the leading causes for death and the leading cause of long-term disability in the USA, and most strokes originate from blood flow blockage known as ischemic stroke. Since the majority of cortical ischemic strokes originate from blockage in the middle cerebral artery (MCA), our lab has studied stroke protection in a rat model of permanent middle cerebral artery occlusion (pMCAo). Our findings have demonstrated that sensory stimulation in the early 2 hours following pMCAo is protective but later (3-4 hours) the same stimulation becomes damaging (known as infarct). It is assumed that the location and volume of either the damaged or protected territory depends on the spatial structure of the occluded artery (e.g., MCA), but research results in our lab point to an alternative hypothesis that the location and volume of an infarcted or protected territory depends on the spread of evoked neuronal activity in cortex. To address our hypothesis, we plan to apply state-of-the-art multi-modal battery of in vivo wide-field imaging techniques including blood flow imaging and functional imaging of cortical activity. These imaging techniques are complemented by optogentic stimulation, electrophysiological recordings using microelectrode arrays, histological, pharmacological treatment studies, and by the development of machine learning algorithms. These techniques will be employed to provide an unprecedented spatiotemporal, quantitative understanding on how the spread of evoked activity is pivotal for predicating the location and volume of the infarcted or protected cortical territory. Finally, to increase the translational potential of these studies, these techniques will be applied in old rats that represent the population most vulnerable to stroke, and in awake, head-fixed young and old rats to increase the translational potential of our research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $416,948 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/8/2025	NON-COMPETING CONTINUATION	$416,948
														Subtotal = $416,948

Issue Date FY: 2025 ( Subtotal = $415,549 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/3/2024	NON-COMPETING CONTINUATION	$415,549
														Subtotal = $415,549

Issue Date FY: 2024 ( Subtotal = $459,204 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/17/2023	NON-COMPETING CONTINUATION	$426,066
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/24/2024	NON-COMPETING CONTINUATION	$33,138
														Subtotal = $459,204

Issue Date FY: 2023 ( Subtotal = $486,389 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/8/2022	NEW	$486,389
														Subtotal = $486,389

Grand Total All Awards = $1,778,090

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The relationship between neuronal activity and stroke

Award Number: R01NS126526

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2022

PERIOD OF PERFORMANCE END DATE: 11/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer