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Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes

Award Number: R01NS126449
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes - Project Abstract Sport-related concussion (SRC) is a significant public health problem resulting in over 200,000 annual trips to the Emergency Department (ED) in the United States with as many as 3.8 million SRCs occurring annually. From a biomechanical standpoint, the concussion mechanism includes head impact resulting in high magnitude head rotational accelerations. Human studies measuring the accelerations associated with concussive head impacts developed injury risk curves that can be extremely useful from the clinical and safety perspectives. However, recent literature has shown that acceleration magnitudes associated with concussive impacts are extremely variable and not necessarily distinct from the routinely sustained head impact magnitudes. Mounting evidence from human studies has demonstrated that repetitive head impact exposure (HIE) may contribute to decreased SRC tolerance in contact sport athletes. Studies focused on quantifying the relationship between the HIE and incident concussion have been underpowered, as there were limited number of concussions occurring during the observation period. We will utilize the data from the NCAA-DoD Concussion Assessment, Research and Education Consortium (CARE) Head Impact Measurement Core, the largest and most comprehensive study of SRC and repetitive HIE to date, and data from Project Head-to-Head 2 (PHTH2), a large-scale study of SRC and HIE in both collegiate and high school athletes to: (1) determine the association of HIE to SRC occurrence and post-SRC recovery based on the frequency, number, recency, and severity of head impacts sustained in football activities; and (2) build a dynamic predictive algorithm of the SRC risk based on the HIE time series data obtained from the HIT System and other factors, including demographics, concussion history, impact characteristics, and network measures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $319,470 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/26/2025	NON-COMPETING CONTINUATION	$319,470
														Subtotal = $319,470

Issue Date FY: 2024 ( Subtotal = $344,724 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/20/2024	NON-COMPETING CONTINUATION	$319,847
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	5/1/2024	NON-COMPETING CONTINUATION	$24,877
														Subtotal = $344,724

Issue Date FY: 2023 ( Subtotal = $355,784 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/17/2023	NON-COMPETING CONTINUATION	$355,784
														Subtotal = $355,784

Issue Date FY: 2022 ( Subtotal = $370,788 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/23/2022	NEW	$370,788
														Subtotal = $370,788

Grand Total All Awards = $1,390,766

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Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes

Award Number: R01NS126449

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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