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Characterization of neurovascular and neurometabolic coupling of the negative BOLD response in human

Award Number: R01NS121040
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary For task-based functional magnetic resonance imaging (fMRI), the positive blood-oxygen-level-dependent (BOLD) response has been widely used and often assumed that it linearly reflects local neural activity. However, a significant portion of brain regions responds with signal decreases upon activation, known as the negative BOLD response (NBR). Although the negative BOLD response (NBR) and its origin have been explored extensively, temporal characteristics and spatial structure of the NBR, and corresponding underlying physiological dynamics are still poorly understood. We propose to investigate dynamics of the NBR evoked by a brief stimulus –the negative hemodynamic response function (nHRF) and its underlying neurovascular and neurometabolic responses using our novel experimental paradigms with high spatiotemporal resolution BOLD and arterial spin labelling (ASL) fMRI modalities. High spatial and temporal resolution BOLD measurements will resolve temporal dynamics of the nHRF as a functional of cortical depth and distance from adjacent positive BOLD responses along the cortical surface. We also evaluated shift-invariant temporal linearity by measuring dynamics of the NBR for varying stimulus durations. Fine spatiotemporal sampling ASL measurements in conjunction with a novel stimulus- onset-time dithering scheme will provide accurate quantification of the cerebral blood flow associated with the NBR within gray matter. We advance our novel computational model based on prompt arterial dynamics observed in recent experimental studies, enabling estimation of realistic neurometabolic response associated with the nHRF. The model will offer a better detailed interpretation of the underlying physiological components associated with the nHRF. Our proposed research will provide a detailed understanding of neurovascular and neurometabolic (de-)coupling associated with nHRF, expanding our knowledge of normal brain functions. Such details with precision to understand the NBR and its physiology was not available in previous studies. Ultimately, success of our proposed research will motivate use of the proposed fMRI approaches and modeling schemes for brain pathologies that involve neurovascular and neurometabolic coupling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $365,955 )
2024	2024	UNIVERSITY OF HEALTH SCIENCE CENTER	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	11/14/2023	NON-COMPETING CONTINUATION	$339,546
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	5/3/2024	NON-COMPETING CONTINUATION	$26,409
2024	2023	UNIVERSITY OF HEALTH SCIENCE CENTER	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	10/26/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $365,955

Issue Date FY: 2023 ( Subtotal = $420,222 )
2023	2023	UNIVERSITY OF HEALTH SCIENCE CENTER	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	9/25/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$420,220
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	9/25/2023	NON-COMPETING CONTINUATION	-$417,630
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	2/1/2023	NON-COMPETING CONTINUATION	$41,762
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/23/2022	NON-COMPETING CONTINUATION	$375,870
														Subtotal = $420,222

Issue Date FY: 2022 ( Subtotal = $395,248 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/24/2021	NEW	$395,248
														Subtotal = $395,248

Grand Total All Awards = $1,181,425

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Characterization of neurovascular and neurometabolic coupling of the negative BOLD response in human

Award Number: R01NS121040

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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