Saturday, June 28, 2025 6/28/2025

Novel Autonomous Roles of CNS Angiogenesis

Award Number: R01NS100808
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2023

Group Awards By:

View Award Description

Novel Autonomous Roles of CNS Angiogenesis - Abstract The central nervous system (CNS) acquires its vasculature by angiogenesis, a process that is critical for its development and repair. Our work has changed notions of cerebral vascularization which implied that blood vessels sprout passively into the brain parenchyma from pial vascular plexuses to meet metabolic needs of growing neuronal populations or treated endothelial cells of the CNS as a homogenous population. Based on origins, anatomical location, independent growth patterns and developmental regulation, forebrain vascular networks fall into two categories: pial and periventricular. The periventricular vascular network that develops in advance of and independent of neuronal development is strategically positioned to provide support and critical guidance cues to instruct neurogenesis and GABAergic interneuron migration in the developing telencephalon. These findings offer new solutions for transplanted primary neuronal precursors that are unable to migrate and integrate into regions requiring new neurons in the absence of proper guidance mechanisms. This application will explore this novel paradigm of neurovascular interactions in diverse ways. It will identify novel angiogenesis mechanisms underlying the origin and etiology of neuropsychiatric diseases. It aims to highlight the novel concept that endothelial GABA signaling is indispensable for brain development shaping postnatal and adult behavior. It attempts to rescue abnormal vascular GABA signaling during embryonic development as a therapeutic approach for long-lasting mental health outcomes. It will examine whether periventricular–like human endothelial cells promote human GABAergic neuronal migration to facilitate development of novel cell based therapies for GABA-related diseases. Results will have far-reaching effects on concepts and mechanisms of regulation of angiogenesis, offer new perspectives on telencephalic histogenesis principles and will lead to discoveries with unprecedented implications for regenerative medicine and treatment of many neurological and psychiatric diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $339,867 )
2021	2021	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	7/29/2021	NON-COMPETING CONTINUATION	$339,867
2021	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	4/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$23,815
2021	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/21/2021	NON-COMPETING CONTINUATION	-$23,815
														Subtotal = $339,867

Issue Date FY: 2020 ( Subtotal = $339,867 )
2020	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/20/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$339,867
2020	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/18/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $339,867

Issue Date FY: 2019 ( Subtotal = $333,965 )
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/8/2019	NON-COMPETING CONTINUATION	$333,965
														Subtotal = $333,965

Issue Date FY: 2018 ( Subtotal = $333,965 )
2018	2018	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/26/2018	NON-COMPETING CONTINUATION	$333,965
														Subtotal = $333,965

Issue Date FY: 2017 ( Subtotal = $347,025 )
2017	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2017	NEW	$347,025
														Subtotal = $347,025

Grand Total All Awards = $1,694,689

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Novel Autonomous Roles of CNS Angiogenesis

Award Number: R01NS100808

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer