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Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & Resilience

Award Number: R01NS085002
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & Resilience - SUMMARY White matter hyperintensities (WMH), which are increasingly more prevalent on brain MRIs, are significantly associated with vascular risk factors and linked to age-related mobility and cognitive impairment. However, not everyone with WMH is equally afflicted and some older individuals are able to maintain their mobility and cognition despite a significant burden of WMH on their brain MRI. We do not know what specific attributes of these individuals contribute to their resilience. Identifying which specific factors are associated with cognitive vulnerability and/or resilience in the presence of WMH is critical for favorably impacting the trajectory of brain health in our aging population, especially among health disparity populations. Over the past 5 years we have been able to identify neuroimaging features associated with vascular risk factors, gait and cognition in midlife. Building on these findings, we now propose to continue our line of inquiry and identify the neuroimaging features associated with gait and cognitive performance in mid- to late-life individuals with WMH, with a specific focus on African Americans and women, both of whom are at a high risk for developing WMH, gait and cognitive impairment, but have often been under-represented in such studies. In Aim1, we will characterize the diffusion properties of the normal appearing white matter (NAWM) and resting brain functional network connections in mid- to late-life individuals who have WMH. These are the neuroimaging features that we have already identified in our midlife cohort study. In Aim 2 we will determine how changes in diffusion properties of NAWM and resting brain function network connections change in relation to gait and cognition in mid- to late life individuals with WMH. Aim3 is an exploratory aim to identify other attributes associated with maintaining gait and cognitive performance in mid- to late-life individuals who display WMH on brain MRI. Findings from the proposed work, will serve two overarching objectives. First, identified neuroimaging features that associate with gait and cognitive performance in individuals with WMH will help guide treatment decisions and allocation of appropriate individuals with WMH for future clinical trials. Second, identified neuroimaging features that associated with gait and cognitive vulnerability &/ or resilience in the presence of WMH will reveal underlying mechanisms and facilitate the future possibility of therapeutic development targeted at mitigating progression to impaired mobility and dementia and expression of Alzheimer’s Disease and related Dementias (ADRD) in at- risk individuals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $719,780 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	3/26/2025	NON-COMPETING CONTINUATION	$719,780
														Subtotal = $719,780

Issue Date FY: 2024 ( Subtotal = $975,689 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	8/13/2024	EXTENSION WITH OR WITHOUT FUNDS	$260,804
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	3/1/2024	EXTENSION WITH OR WITHOUT FUNDS	$714,885
														Subtotal = $975,689

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/24/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $447,036 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/15/2017	NON-COMPETING CONTINUATION	$44,702
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/17/2017	NON-COMPETING CONTINUATION	$402,334
														Subtotal = $447,036

Issue Date FY: 2016 ( Subtotal = $447,036 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	5/12/2016	NON-COMPETING CONTINUATION	$93,450
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	4/8/2016	NON-COMPETING CONTINUATION	$353,586
2016	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	12/24/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$292,109
2016	2015	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/23/2015	NON-COMPETING CONTINUATION	-$292,109
														Subtotal = $447,036

Issue Date FY: 2015 ( Subtotal = $380,109 )
2015	2015	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/4/2015	NON-COMPETING CONTINUATION	$380,109
														Subtotal = $380,109

Issue Date FY: 2014 ( Subtotal = $418,259 )
2014	2014	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/16/2014	NEW	$418,259
														Subtotal = $418,259

Grand Total All Awards = $3,387,909

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Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & Resilience

Award Number: R01NS085002

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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