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Rapid Estrogen Signaling in Brain Circuits that Guide Complex Behavior

Award Number: R01NS082179
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/22/2014
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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View Award Description

Rapid Estrogen Signaling in Brain Circuits that Guide Complex Behavior - PROJECT SUMMARY Neuromodulators like oxytocin, dopamine, serotonin, and catecholamines regulate the activity of forebrain neurons during sensory and cognitive tasks. This scale of neuromodulation allows neural circuits to dynamically encode and respond to sensory stimuli depending on contexts like parenting, aggression, mating, and stress. Neuromodulators classically enhance stimulus extraction from noisy backgrounds, and this regulation is crucial for learning and memory. A recently-discovered neuromodulatory system - the synthesis and action of ‘neuroestrogens’ by specific neuronal cell types – holds a great deal of promise for sensory perception, memory, and cognitive function. In human patients, estrogens can be beneficial treatments for a variety of neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and epilepsy. Yet because the neuromodulatory perspective of brain estrogen synthesis is relatively new, the therapeutic potential of neuroestrogen signaling itself is untapped. This unmet potential is also hampered by our poor understanding of the cellular and circuit mechanisms for neuroestrogen signaling, and their implications for complex behavior. The research program in this proposal will specifically study how neuroestrogens regulate the cellular, microcircuit, and network interactions between excitatory and inhibitory neurons, and situate these outcomes in ethologically-relevant behaviors. Our proposed experiments will clarify the neural circuit mechanisms for neuroestrogen signaling by unraveling the specific contribution of inhibitory and excitatory neurons, including their chemical and electrical synaptic interactions. The proposed projects will take advantage of recent molecular and technological advances that allow us to genetically target fast-spiking inhibitory neurons and principal excitatory neurons in the songbird forebrain. This work will therefore address a fundamental gap in our understanding of how estrogen production within the brain guides complex behavior, and could ultimately inform the development of highly-targeted estrogen therapies for cognitive and neurological disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $437,823 )
2026	2026	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	4/24/2026	COMPETING CONTINUATION	$437,823
														Subtotal = $437,823

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	8/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $337,162 )
2023	2023	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	2/25/2023	NON-COMPETING CONTINUATION	$337,162
														Subtotal = $337,162

Issue Date FY: 2022 ( Subtotal = $337,162 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	3/28/2022	NON-COMPETING CONTINUATION	$33,718
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	2/25/2022	NON-COMPETING CONTINUATION	$303,444
														Subtotal = $337,162

Issue Date FY: 2021 ( Subtotal = $337,162 )
2021	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	3/15/2021	NON-COMPETING CONTINUATION	$337,162
														Subtotal = $337,162

Issue Date FY: 2020 ( Subtotal = $334,531 )
2020	2020	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	3/9/2020	NON-COMPETING CONTINUATION	$334,531
														Subtotal = $334,531

Issue Date FY: 2019 ( Subtotal = $363,406 )
2019	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	6/7/2019	COMPETING CONTINUATION	$203,962
2019	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	4/3/2019	COMPETING CONTINUATION	$363,406
2019	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/7/2019	NON-COMPETING CONTINUATION	-$203,962
														Subtotal = $363,406

Issue Date FY: 2018 ( Subtotal = $342,134 )
2018	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	4/27/2018	NON-COMPETING CONTINUATION	$34,214
2018	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/29/2018	NON-COMPETING CONTINUATION	$307,920
														Subtotal = $342,134

Issue Date FY: 2017 ( Subtotal = $342,405 )
2017	2017	UNIVERSITY OF MASSACHUSETTS	70 BUTTERFIELD TERRACE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	6/5/2017	NON-COMPETING CONTINUATION	$34,241
2017	2017	UNIVERSITY OF MASSACHUSETTS	70 BUTTERFIELD TERRACE	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/5/2017	NON-COMPETING CONTINUATION	$308,164
														Subtotal = $342,405

Issue Date FY: 2016 ( Subtotal = $342,662 )
2016	2016	UNIVERSITY OF MASSACHUSETTS	406C-1 GOODELL BUILDING	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/22/2016	NON-COMPETING CONTINUATION	$342,662
														Subtotal = $342,662

Issue Date FY: 2015 ( Subtotal = $335,164 )
2015	2015	UNIVERSITY OF MASSACHUSETTS	406C-1 GOODELL BUILDING	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/6/2015	NON-COMPETING CONTINUATION	$335,164
														Subtotal = $335,164

Issue Date FY: 2014 ( Subtotal = $332,816 )
2014	2014	UNIVERSITY OF MASSACHUSETTS	406C-1 GOODELL BUILDING	AMHERST	MA	01003	HAMPSHIRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/28/2014	NEW	$332,816
														Subtotal = $332,816

Grand Total All Awards = $3,842,427

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Rapid Estrogen Signaling in Brain Circuits that Guide Complex Behavior

Award Number: R01NS082179

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/22/2014

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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