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Network Properties of Circadian Clock Modulation and Entrainment

Award Number: R01NS077933
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Network Properties of Circadian Clock Modulation and Entrainment - Abstract Circadian clocks orchestrate endogenous daily rhythms in physiology, metabolism, and behavior that must be adjusted (i.e., entrained) to environmental cycles to maintain properly timed outputs. Post- industrial environments have significantly reduced the reliability of the time cues that the circadian system relies upon for entrainment and this has had widespread and negative consequences for human health. Understanding the network properties of circadian timekeeping in the brain and the ways in which time cues impinge upon it is required if we are to address the adverse effects of circadian misalignment and dysfunction. The complexity of the brain’s clock center is a significant barrier to our understanding of the daily adjustment of the circadian system. Work in relatively “simple” clock neuron networks can therefore enrich and inform our understanding of circadian timekeeping and entrainment in the mammalian brain. The goal of this competing renewal application is to continue a productive and impactful research program on the network properties of circadian timekeeping and entrainment in Drosophila melanogaster, which, despite its relative simplicity, shares molecular, anatomical, and physiological features that are remarkably similar to those of mammalian clock networks. Within the fly’s clock neuron network, we will determine how endogenous circadian timekeeping is supported by the network structure of the of the brain’s clock center and how specific neural pathways and neurotransmitters mediate entrainment to environmental cycles. The goals of our three specific aims are to elucidate: 1) the nature and timekeeping functions of the synaptic and modulatory connections of the circadian clock neuron network, 2.) how the CCNN integrates light input to entrain circadian rhythms, and 3) how neurons that do not themselves express molecular clocks participate in the clock neuron network to support endogenous timekeeping. The unifying goal of this research program is to advance our understanding of circadian timekeeping and entrainment in the brain. The results of this work will inform future interventions for the alleviation of the adverse health effects of circadian dysfunction in post-industrial environments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	3/6/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $375,165 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	13	8/6/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$375,165
2024	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	12	8/5/2024	COMPETING CONTINUATION	$0
2024	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	6/5/2024	COMPETING CONTINUATION	$0
2024	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	11/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $375,165

Issue Date FY: 2023 ( Subtotal = $395,000 )
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	7/20/2023	COMPETING CONTINUATION	$392,500
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	8/10/2023	COMPETING CONTINUATION	$2,500
														Subtotal = $395,000

Issue Date FY: 2022 ( Subtotal = $339,467 )
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	10/29/2021	NON-COMPETING CONTINUATION	$305,520
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 SAINT NICHOLAS TER	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	3/25/2022	NON-COMPETING CONTINUATION	$33,947
														Subtotal = $339,467

Issue Date FY: 2021 ( Subtotal = $339,577 )
2021	2021	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	12/1/2020	NON-COMPETING CONTINUATION	$305,619
2021	2021	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	1/18/2021	NON-COMPETING CONTINUATION	$33,958
														Subtotal = $339,577

Issue Date FY: 2020 ( Subtotal = $339,683 )
2020	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	11/8/2019	NON-COMPETING CONTINUATION	$305,714
2020	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	2/10/2020	NON-COMPETING CONTINUATION	$33,969
														Subtotal = $339,683

Issue Date FY: 2019 ( Subtotal = $344,122 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	11/23/2018	NON-COMPETING CONTINUATION	$329,038
2019	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	8	3/22/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$343,438
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	3/22/2019	NON-COMPETING CONTINUATION	-$328,354
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	7	6/7/2019	NON-COMPETING CONTINUATION	-$684
2019	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	85 ST NICHOLAS TERRACE	NEW YORK	NY	10031	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	8	6/7/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$24,526
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	6/7/2019	COMPETING CONTINUATION	-$23,842
														Subtotal = $344,122

Issue Date FY: 2018 ( Subtotal = $328,354 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	5/2/2018	COMPETING CONTINUATION	$198,946
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	11/9/2017	COMPETING CONTINUATION	$328,354
2018	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	11/7/2017	NON-COMPETING CONTINUATION	$0
2018	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	5/2/2018	NON-COMPETING CONTINUATION	-$198,946
														Subtotal = $328,354

Issue Date FY: 2017 ( Subtotal = $321,907 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	11/3/2016	NON-COMPETING CONTINUATION	$289,716
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/14/2017	NON-COMPETING CONTINUATION	$32,191
														Subtotal = $321,907

Issue Date FY: 2016 ( Subtotal = $322,940 )
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	11/11/2015	EXTENSION WITH OR WITHOUT FUNDS	$290,646
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/11/2016	EXTENSION WITH OR WITHOUT FUNDS	$32,294
														Subtotal = $322,940

Issue Date FY: 2015 ( Subtotal = $323,915 )
2015	2015	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/4/2014	NON-COMPETING CONTINUATION	$323,915
														Subtotal = $323,915

Issue Date FY: 2014 ( Subtotal = $321,586 )
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/21/2013	NON-COMPETING CONTINUATION	$292,351
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/17/2014	NON-COMPETING CONTINUATION	$29,235
														Subtotal = $321,586

Issue Date FY: 2012 ( Subtotal = $325,701 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/24/2012	NEW	$325,701
														Subtotal = $325,701

Grand Total All Awards = $4,077,417

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Network Properties of Circadian Clock Modulation and Entrainment

Award Number: R01NS077933

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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