Sunday, May 11, 2025 5/11/2025

Neurotrophins and Epileptogenesis

Award Number: R01NS056217
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Neurotrophins and Epileptogenesis - Project Summary Lack of preventive and disease modifying treatments for common disorders of the human nervous system is a glaring unmet medical need critical to the mission of NINDS. The work proposed here represents a novel approach to uncover molecular signaling mechanisms underlying temporal lobe epilepsy (TLE). Work accomplished during the current funding period reveals a pivotal role for the brain-derived neurotrophic factor (BDNF) receptor tyrosine kinase,TrkB, in the development of TLE induced by status epilepticus. TrkB-mediated activation of the effector, phospholipase C1, is the dominant pathway by which TrkB promotes development of TLE. The objective of the current application is to explore the role of TrkB signaling in the persistence of TLE. To accomplish this objective, we will examine the effect of pharmacological and genetic perturbations of TrkB signaling on epilepsy induced in diverse models of TLE. Successful completion of the work proposed may pave the way to preventive and/or disease modifying therapy of TLE, a common disorder of the human central nervous system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $493,338 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	3/30/2023	NON-COMPETING CONTINUATION	$493,338
														Subtotal = $493,338

Issue Date FY: 2022 ( Subtotal = $493,338 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	3/31/2022	NON-COMPETING CONTINUATION	$493,338
														Subtotal = $493,338

Issue Date FY: 2021 ( Subtotal = $493,338 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	15	3/10/2021	NON-COMPETING CONTINUATION	$493,338
														Subtotal = $493,338

Issue Date FY: 2020 ( Subtotal = $493,338 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	14	3/16/2020	NON-COMPETING CONTINUATION	$493,338
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	1/15/2020	COMPETING CONTINUATION	$0
														Subtotal = $493,338

Issue Date FY: 2019 ( Subtotal = $515,911 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	5/31/2019	COMPETING CONTINUATION	$515,911
2019	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	2/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $515,911

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	6/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $342,196 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	5/30/2017	NON-COMPETING CONTINUATION	$342,196
														Subtotal = $342,196

Issue Date FY: 2016 ( Subtotal = $342,412 )
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	5/10/2016	NON-COMPETING CONTINUATION	$342,412
														Subtotal = $342,412

Issue Date FY: 2015 ( Subtotal = $342,619 )
2015	2015	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	6/9/2015	NON-COMPETING CONTINUATION	$342,619
														Subtotal = $342,619

Issue Date FY: 2014 ( Subtotal = $338,614 )
2014	2014	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	6/9/2014	COMPETING CONTINUATION	$338,614
														Subtotal = $338,614

Issue Date FY: 2013 ( Subtotal = $322,720 )
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	6/20/2013	NON-COMPETING CONTINUATION	$322,720
														Subtotal = $322,720

Issue Date FY: 2012 ( Subtotal = $334,425 )
2012	2012	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/21/2012	NON-COMPETING CONTINUATION	$334,425
														Subtotal = $334,425

Issue Date FY: 2011 ( Subtotal = $334,425 )
2011	2011	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/18/2011	NON-COMPETING CONTINUATION	$334,425
														Subtotal = $334,425

Issue Date FY: 2010 ( Subtotal = $341,250 )
2010	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/13/2010	COMPETING CONTINUATION	$341,250
														Subtotal = $341,250

Issue Date FY: 2009 ( Subtotal = $382,731 )
2009	2009	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/5/2009	NON-COMPETING CONTINUATION	$382,731
														Subtotal = $382,731

Issue Date FY: 2008 ( Subtotal = $375,024 )
2008	2008	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/12/2008	NON-COMPETING CONTINUATION	$375,024
														Subtotal = $375,024

Issue Date FY: 2007 ( Subtotal = $389,090 )
2007	2007	DUKE UNIVERSITY	BOX 104135	DURHAM	NC	27708	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/2/2007	NON-COMPETING CONTINUATION	$389,090
														Subtotal = $389,090

Issue Date FY: 2006 ( Subtotal = $388,977 )
2006	2006	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/14/2006	NEW	$388,977
														Subtotal = $388,977

Grand Total All Awards = $6,723,746

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Neurotrophins and Epileptogenesis

Award Number: R01NS056217

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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