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TNF in Injury and Repair Processes Following Traumatic SCI

Award Number: R01NS051709
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2005
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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TNF in Injury and Repair Processes Following Traumatic SCI - Abstract Chronic neuropathic pain (CNP) is a maladaptive pathological process that is poorly understood and a condition for which no effective therapies exist. It is largely recognized that neuroinflammation significantly contributes to the development of chronic pain, however the mechanisms are not well understood. A unifying mechanism through which pathological inflammation contributes to the development of chronic pain is by being a key mediator of neuropathology and maladaptive plasticity in brain regions critical for processing somatosensory information such as the somatosensory cortex (S1). The overarching hypothesis to be tested in this competitive renewal is that strategies designed to mitigate pathological neuroinflammation will be therapeutic for spinal cord injury (SCI)-Pain by promoting neurorepair and reducing maladaptive supraspinal plasticity. The studies proposed in this application are based upon extensive published and preliminary data demonstrating diverging roles for TNFR (TNFR1 and TNFR2) signaling and sex differences in the development and resolution of CNP in SCI and peripheral nerve injury (CCI) models. The overarching goals of our competitive renewal are to better understand mechanisms of CNP and to develop therapies that are effective in both women and men. The lack of understanding of neuron-immune cell interactions that lead to the development or resolution of chronic pain is the overarching scientific premise to this application. Our scientific premise and hypotheses will be tested in the following Specific Aims. Specific Aim1: Interrogate the mechanisms through which TNFR2 signaling mitigates neuroinflammation in CNP in males and females. Specific Aim 2: Interrogate the divergent roles for TNFR signaling in the development and resolution of CNP and maladaptive plasticity in males and females. Specific Aim 3: Interrogate the intersection between TNFR1 and ERβ in females and mechanisms whereby inhibiting ERβ in females renders them “male-like” with respect to therapies for CNP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $465,601 )
2025	2025	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	18	6/12/2025	NON-COMPETING CONTINUATION	$465,601
														Subtotal = $465,601

Issue Date FY: 2024 ( Subtotal = $497,283 )
2024	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	8/14/2024	COMPETING CONTINUATION	$497,283
														Subtotal = $497,283

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	3/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $516,653 )
2019	2019	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	8/29/2019	NON-COMPETING CONTINUATION	$516,653
														Subtotal = $516,653

Issue Date FY: 2018 ( Subtotal = $516,891 )
2018	2018	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	15	8/20/2018	NON-COMPETING CONTINUATION	$516,653
2018	2014	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	11/21/2017	NON-COMPETING CONTINUATION	$238
														Subtotal = $516,891

Issue Date FY: 2017 ( Subtotal = $516,653 )
2017	2017	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	14	8/18/2017	NON-COMPETING CONTINUATION	$516,653
2017	2015	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	2/7/2017	COMPETING CONTINUATION	$190,264
2017	2014	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	2/7/2017	NON-COMPETING CONTINUATION	-$190,264
														Subtotal = $516,653

Issue Date FY: 2016 ( Subtotal = $516,653 )
2016	2016	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	8/19/2016	NON-COMPETING CONTINUATION	$516,653
														Subtotal = $516,653

Issue Date FY: 2015 ( Subtotal = $524,468 )
2015	2015	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	9/18/2015	COMPETING CONTINUATION	$524,468
2015	2014	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	9/18/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $524,468

Issue Date FY: 2014 ( Subtotal = $442,297 )
2014	2014	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	11	7/2/2014	NON-COMPETING CONTINUATION	$442,297
2014	2013	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	4/4/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$123,152
2014	2013	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	4/4/2014	NON-COMPETING CONTINUATION	-$123,152
														Subtotal = $442,297

Issue Date FY: 2013 ( Subtotal = $428,208 )
2013	2013	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	4/4/2014	NON-COMPETING CONTINUATION	-$123,152
2013	2013	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	5/15/2013	NON-COMPETING CONTINUATION	$428,208
2013	2013	DREXEL UNIVERSITY	3201 ARCH STREET, SUITE 100	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	10	4/4/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$123,152
														Subtotal = $428,208

Issue Date FY: 2012 ( Subtotal = $446,022 )
2012	2012	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	4/17/2012	NON-COMPETING CONTINUATION	$446,022
														Subtotal = $446,022

Issue Date FY: 2011 ( Subtotal = $448,283 )
2011	2011	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/30/2011	NON-COMPETING CONTINUATION	$448,283
														Subtotal = $448,283

Issue Date FY: 2010 ( Subtotal = $477,918 )
2010	2010	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	5/12/2010	COMPETING CONTINUATION	$477,918
2010	2009	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/10/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $477,918

Issue Date FY: 2009 ( Subtotal = $332,190 )
2009	2009	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/18/2008	NON-COMPETING CONTINUATION	$298,970
2009	2009	UNIVERSITY OF MIAMI	P.O. BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	3/30/2009	NON-COMPETING CONTINUATION	$33,220
														Subtotal = $332,190

Issue Date FY: 2008 ( Subtotal = $332,190 )
2008	2008	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/6/2008	NON-COMPETING CONTINUATION	$332,190
														Subtotal = $332,190

Issue Date FY: 2007 ( Subtotal = $332,190 )
2007	2007	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/8/2007	NON-COMPETING CONTINUATION	$332,190
														Subtotal = $332,190

Issue Date FY: 2006 ( Subtotal = $342,111 )
2006	2006	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/2/2006	NON-COMPETING CONTINUATION	$342,111
														Subtotal = $342,111

Issue Date FY: 2005 ( Subtotal = $350,344 )
2005	2005	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/11/2005	NEW	$350,344
														Subtotal = $350,344

Grand Total All Awards = $7,485,955

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TNF in Injury and Repair Processes Following Traumatic SCI

Award Number: R01NS051709

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2005

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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