Thursday, May 29, 2025 5/29/2025

Laminin Receptors and Signals in Schwann Cells

Award Number: R01NS045630
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Laminin Receptors and Signals in Schwann Cells - Peripheral neuropathies are a common cause of disability and have no cure. The extracellular signals that drive Schwann cell differentiation are important for peripheral nervous system myelination and are potentially accessible to improve failure in certain human peripheral neuropathies. In previous grant cycles, my laboratory identified essential Schwann cell signaling pathways that are modulated by LAMININS in the extracellular matrix. Among them, RAC1, a small-RhoGTPase and YAP and TAZ, effectors of the HIPPO pathway, are essential for normal Schwann cell development. The proposed research will characterize how RAC1 and the HIPPO pathway intersect and identify novel components of these pathways. The novel components include STRIATIN3 and MOB4, members of the STRIPAK complex that we identified as novel RAC1 interactors, and the atypical cadherin CELSR2, a putative mediator of Schwann cell-axon interactions. Preliminary data show that STRIATIN3 and CELSR2 may be important for myelination. Furthermore, this research will identify upstream regulators of the HIPPO pathway in Schwann cells using unbiased approaches. YAP and TAZ may also modulate human neuropathies by mediating mechanical signals and by controlling the expression of genes such as Peripheral Myelin Protein 22 (PMP22), whose altered gene dosage causes 80% of Charcot-Marie-Tooth disease (CMT) cases. To determine if YAP and TAZ modulate PMP22 expression in the context of CMT, YAP and TAZ mutants will be crossed with CMT1 models to determine if PMP22 expression and the consequent phenotypes are modulated. This work will reveal novel fundamental regulators of two important signaling pathways in Schwann cells. As the function of RAC1 and the HIPPO pathway is conserved in different cell types, this work will elucidate novel aspects of cell biology, in addition to myelination, and may reveal ways to modulate signaling pathways relevant in human neuropathies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$40 )
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	19	4/29/2025	NON-COMPETING CONTINUATION	-$40
														Subtotal = -$40

Issue Date FY: 2024 ( Subtotal = $376,510 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	19	4/2/2024	NON-COMPETING CONTINUATION	$376,510
														Subtotal = $376,510

Issue Date FY: 2023 ( Subtotal = $367,100 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	18	2/11/2023	NON-COMPETING CONTINUATION	$367,100
														Subtotal = $367,100

Issue Date FY: 2022 ( Subtotal = $403,609 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	3/31/2022	NON-COMPETING CONTINUATION	$403,609
														Subtotal = $403,609

Issue Date FY: 2021 ( Subtotal = $399,475 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	1/30/2021	NON-COMPETING CONTINUATION	$399,475
														Subtotal = $399,475

Issue Date FY: 2020 ( Subtotal = $405,006 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	15	7/8/2020	COMPETING CONTINUATION	$34,943
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	15	1/29/2020	COMPETING CONTINUATION	$405,006
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	14	7/8/2020	NON-COMPETING CONTINUATION	-$34,943
														Subtotal = $405,006

Issue Date FY: 2018 ( Subtotal = $345,268 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	14	4/27/2018	NON-COMPETING CONTINUATION	$34,527
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	1/18/2018	NON-COMPETING CONTINUATION	$310,741
														Subtotal = $345,268

Issue Date FY: 2017 ( Subtotal = $343,943 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	1/20/2017	NON-COMPETING CONTINUATION	$309,548
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	6/20/2017	NON-COMPETING CONTINUATION	$34,395
														Subtotal = $343,943

Issue Date FY: 2016 ( Subtotal = $409,888 )
2016	2016	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	2/11/2016	NON-COMPETING CONTINUATION	$404,671
2016	2016	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	12/26/2015	SUPPLEMENT FOR EXPANSION	$5,217
														Subtotal = $409,888

Issue Date FY: 2015 ( Subtotal = $346,982 )
2015	2015	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	1/22/2015	NON-COMPETING CONTINUATION	$346,982
														Subtotal = $346,982

Issue Date FY: 2014 ( Subtotal = $346,484 )
2014	2014	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	2/10/2014	COMPETING CONTINUATION	$346,484
														Subtotal = $346,484

Issue Date FY: 2011 ( Subtotal = $339,784 )
2011	2011	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	8/3/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$339,784
2011	2010	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/3/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $339,784

Issue Date FY: 2010 ( Subtotal = $233,888 )
2010	2010	ISTITUTO SCIENTIFICO SAN RAFFAELE	VIA OLGETTINA, 60 MILAN	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	6/9/2010	NON-COMPETING CONTINUATION	$233,888
														Subtotal = $233,888

Issue Date FY: 2009 ( Subtotal = $236,250 )
2009	2009	ISTITUTO SCIENTIFICO SAN RAFFAELE	VIA OLGETTINA, 60 MILAN	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	6/16/2009	NON-COMPETING CONTINUATION	$236,250
														Subtotal = $236,250

Issue Date FY: 2008 ( Subtotal = $236,250 )
2008	2008	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/3/2008	NON-COMPETING CONTINUATION	$236,250
														Subtotal = $236,250

Issue Date FY: 2007 ( Subtotal = $236,250 )
2007	2007	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/30/2007	COMPETING CONTINUATION	$236,250
														Subtotal = $236,250

Issue Date FY: 2006 ( Subtotal = $225,425 )
2006	2006	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/25/2006	NON-COMPETING CONTINUATION	$225,425
														Subtotal = $225,425

Issue Date FY: 2005 ( Subtotal = $230,850 )
2005	2005	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/25/2005	NON-COMPETING CONTINUATION	$230,850
														Subtotal = $230,850

Issue Date FY: 2004 ( Subtotal = $230,850 )
2004	2004	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/13/2004	NON-COMPETING CONTINUATION	$230,850
														Subtotal = $230,850

Issue Date FY: 2003 ( Subtotal = $230,850 )
2003	2003	SAN RAFFAELE SCIENTIFIC INSTIUTE	VIA OLGETTINA 60	MILAN				ITA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/28/2003	NEW	$230,850
														Subtotal = $230,850

Grand Total All Awards = $5,944,622

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Laminin Receptors and Signals in Schwann Cells

Award Number: R01NS045630

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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