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POST-EMBRYONIC DEVELOPMENT OF THE DROSOPHILA BRAIN

Award Number: R01NS042049
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2001
PERIOD OF PERFORMANCE END DATE: 07/31/2010

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POST-EMBRYONIC DEVELOPMENT OF THE DROSOPHILA BRAIN - DESCRIPTION (provided by applicant): Brain development involves orderly generation of distinct types of neurons, establishment of stereotyped neuronal connections, and developmentally programmed as well as activity-dependent remodeling of neuronal projections. In addition, like neurons, glial cells are integral to both formation and function of the brain. To elucidate the molecular mechanisms governing brain development, we propose to continue studying post-embryonic development of the Drosophila brain that involves various interesting developmental phenomena, such as extensive neurogenesis and gliogenesis in functional neural circuits and large-scale remodeling of neural circuits during metamorphosis. First, we will identify additional molecules required for various aspects of post-embryonic development of the Drosophila brain via isolating and characterizing more mushroom body mutants. Second, we will investigate whether and how numerous distinct DSCAM molecules operate collaboratively and/or differentially to mediate diverse cell type-specific neuronal morphogenesis. Third, we will develop novel MARCM technology for examining post-embryonic neurogenesis and gliogenesis systematically and simultaneously. Studying post-embryonic development of the Drosophila brain promises to shed new light on how complex neural circuits form in human brains. In particular, we expect to gain novel insights into the molecular mechanisms that govern (1) derivation of different types of neurons from common precursors, (2) chronologically appropriate neuronal morphogenesis, (3) formation/extension/guidance/arborization of dendrites versus axons, (4) remodeling of neuronal projections, (5) diverse cell type-specific neuronal morphogenesis, and (6) neuron-glial interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $356,309 )
2009	2009	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	7/20/2009	NON-COMPETING CONTINUATION	$356,309
														Subtotal = $356,309

Issue Date FY: 2008 ( Subtotal = $356,309 )
2008	2008	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	7/17/2008	NON-COMPETING CONTINUATION	$356,309
														Subtotal = $356,309

Issue Date FY: 2007 ( Subtotal = $356,309 )
2007	2007	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/6/2007	NON-COMPETING CONTINUATION	$356,309
														Subtotal = $356,309

Issue Date FY: 2006 ( Subtotal = $365,822 )
2006	2006	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	8/2/2006	NON-COMPETING CONTINUATION	$365,822
														Subtotal = $365,822

Issue Date FY: 2005 ( Subtotal = $345,831 )
2005	2005	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/11/2005	COMPETING CONTINUATION	$345,831
														Subtotal = $345,831

Issue Date FY: 2004 ( Subtotal = $222,379 )
2004	2004	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/8/2004	NON-COMPETING CONTINUATION	$222,379
														Subtotal = $222,379

Issue Date FY: 2003 ( Subtotal = $222,587 )
2003	2003	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/1/2003	NON-COMPETING CONTINUATION	$222,587
														Subtotal = $222,587

Issue Date FY: 2002 ( Subtotal = $222,788 )
2002	2002	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/19/2002	NON-COMPETING CONTINUATION	$222,788
														Subtotal = $222,788

Issue Date FY: 2001 ( Subtotal = $272,984 )
2001	2001	UNIVERSITY OF ILLINOIS URBANA CAMPUS	809 SOUTH WRIGHT STREET	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/27/2001	NEW	$272,984
														Subtotal = $272,984

Grand Total All Awards = $2,721,318

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POST-EMBRYONIC DEVELOPMENT OF THE DROSOPHILA BRAIN

Award Number: R01NS042049

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2001

PERIOD OF PERFORMANCE END DATE: 07/31/2010

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