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 | Issue Date FY: 2025 ( Subtotal = $63,585,812 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS126821 | Cellular and Molecular Mechanisms Underlying Neuronal Type-specific Axon Regeneration | 000 | 3 | NIH | 1/16/2025 | $376,875 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM156361 | Structural mechanisms of multimeric ATPases | 000 | 1 | NIH | 12/24/2024 | $669,281 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | T32GM135751 | IMSD at the University of Massachusetts Chan Medical School | 000 | 6 | NIH | 1/31/2025 | $245,448 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01AI172987 | Development of targeted microbiome therapeutics and dietary interventions for potent intestinal barrier promotion to minimize GI-ARS | 000 | 3 | NIH | 12/5/2024 | $568,565 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI182355 | Combining B. thuringiensis crystal proteins with small molecule anthelmintics to combat parasitic nematode resistance | 000 | 1 | NIH | 12/16/2024 | $769,201 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS076991 | Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and Leukodystrophies | 001 | 11 | NIH | 1/22/2025 | $533,982 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01MH113743 | Microglia-Astrocyte Crosstalk Regulating SynapseRemodeling | 000 | 9 | NIH | 3/5/2025 | $459,516 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM148225 | Dissecting the Molecular Mechanisms of Exocytic Vesicle Tethering and Fusion | 001 | 3 | NIH | 4/4/2025 | $669,060 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01HD111505 | Unmasking the role of maternal transcript UTRs in reproductive fecundity | 000 | 2 | NIH | 4/4/2025 | $360,125 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01EB032674 | Next-Generation Thalamic Nuclei Visualization and Segmentation Methods | 000 | 4 | NIH | 4/17/2025 | $428,670 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | UH3HL145266 | 1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study | 002 | 7 | NIH | 3/26/2025 | $977,233 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R33HL158540 | Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients | 002 | 5 | NIH | 3/27/2025 | $1,586,887 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS106985 | A Chemosensory-Mechanotransduction System Regulating Ventricular Size and Brain Function | 000 | 6 | NIH | 4/9/2025 | $555,440 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI114495 | Role of Tspan5 in MHC I antigen presentation and cancer immune evasion | 000 | 10 | NIH | 4/9/2025 | $492,997 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK107603 | Mucosal Macrophages and Tertiary Lymphoid Structures in IBD | 000 | 10 | NIH | 2/20/2025 | $492,283 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM145263 | Transgenerational epigenetic regulation by Rlim | 001 | 4 | NIH | 2/20/2025 | $376,875 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R25DA058490 | The ANTIDOTE Institute- Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts | 000 | 3 | NIH | 4/9/2025 | $314,491 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM150669 | Discovery and characterization of bacterial cell envelope assembly and remodeling networks that modulate tolerance to antibiotics | 000 | 3 | NIH | 4/10/2025 | $418,750 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AA028240 | A Female-Specific Cognitive Behavioral Therapy Group for Alcohol Use Disorder in VA Primary Care Settings | 000 | 5 | NIH | 2/27/2025 | $581,852 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01CA271613 | Role of EZH2 as a Driver and Therapeutic Target of Hepatocellular Carcinoma | 000 | 3 | NIH | 4/10/2025 | $415,798 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01EB037025 | Synthetic RNA Switch-Based Temporal and Dose Control of in Vivo Gene Therapies | 000 | 1 | NIH | 2/26/2025 | $540,524 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U24HG012343 | A Comprehensive Genomic Community Resource of Transcriptional Regulation | 000 | 4 | NIH | 4/10/2025 | $878,671 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31CA288119 | Investigating replication gap suppression in distinct modelsof chemoresistant BRCA mutant cancers | 000 | 1 | NIH | 4/14/2025 | $33,784 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK136321 | EpoR & Stat5 regulation of ribosome biogenesis and protein synthesis in erythropoiesis | 000 | 3 | NIH | 3/14/2025 | $463,690 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI167009 | In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticles | 001 | 4 | NIH | 4/10/2025 | $125,000 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI167009 | In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticles | 001 | 4 | NIH | 4/10/2025 | $705,363 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM127094 | Translational Control: Discovery and Mechanisms | 001 | 8 | NIH | 4/15/2025 | $645,311 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01HD072122 | Epigenetic control of developmental gene regulation | 000 | 14 | NIH | 4/15/2025 | $482,124 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31NS143369 | Single-Cell Analysis of Somatic Mutation Rates, Mechanisms, and Impacts in Human Ataxia Telangiectasia Cerebellum | 000 | 1 | NIH | 4/17/2025 | $33,890 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AG083881 | Transcriptomics-based identification of cell type specific host genes and gene networks perturbed by HSV-1 in cerebral organoids. | 000 | 2 | NIH | 4/17/2025 | $753,743 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F32AI176649 | Glutamine Starvation as a Means to Enhance Antibiotic Efficacy against M. tuberculosis | 000 | 2 | NIH | 4/14/2025 | $76,756 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K22CA288784 | Deciphering the Immune Evasion Mechanisms in Mutant IDH1 Cancer | 000 | 1 | NIH | 3/18/2025 | $196,029 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01EB033581 | MINDER: Wearable sensor-based detection of digital biomarkers of adherence to medications for opioid use disorder | 000 | 3 | NIH | 4/15/2025 | $644,774 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21DA058174 | Single-cell molecular rhythm alterations in human nucleus accumbens associated with opioid use disorder | 000 | 2 | NIH | 3/31/2025 | $193,146 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21NS139100 | Investigating Dysfunction of Neuroimmune-Related Processes in Models of ALS/FTD TDP-43 | 000 | 1 | NIH | 3/20/2025 | $251,250 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K23NS126718 | MRI Paramagnetic Rim Lesions as Biomarkers and Agents of Neurodegeneration in Multiple Sclerosis | 000 | 4 | NIH | 3/19/2025 | $221,553 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31NS127555 | Establishing and Optimizing a Prime Editing Method in Neurons for Treatment of Rett Syndrome | 001 | 3 | NIH | 3/20/2025 | -$26,734 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AR081355 | Cellular and molecular regulators of melanocyte regeneration | 000 | 3 | NIH | 3/24/2025 | $388,205 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI159314 | Altered T Cell Responses in Myalgic Enchephalomeylitis/Chronic Fatigue Syndrome (ME/CFS) | 000 | 5 | NIH | 2/14/2025 | $474,267 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NR020439 | Structural Racism and Engagement of Family Caregivers in Serious Illness Care | 000 | 4 | NIH | 2/14/2025 | $631,908 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AG073238 | Effects of paternal aging on male reproductive biology and on future generations | 000 | 5 | NIH | 3/24/2025 | $458,024 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37CA282805 | Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis | 000 | 2 | NIH | 3/7/2025 | $344,841 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01GM145062 | Post-transcriptional regulation of germline mRNAs in C. elegans | 000 | 4 | NIH | 3/25/2025 | $310,546 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01CA258712 | Targeting MTOR signaling in pancreatic cancer | 000 | 4 | NIH | 4/8/2025 | $527,183 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS118145 | Protein Arginine Deiminase 2 (PAD2) and Protein Citrullination in ALS | 000 | 5 | NIH | 4/8/2025 | $487,663 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31AI191705 | Linking Mycobacterium Tuberculosis infection outcomes with transcriptional networks in genetically diverse mouse macrophages | 000 | 1 | NIH | 4/8/2025 | $34,566 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31NS132495 | Investigating the Role of cnb-1 and chpf-1 in GABA DD Motor Neuron Remodeling and Synapse Maintenance | 000 | 3 | NIH | 3/11/2025 | $36,260 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | H7600689 | Ryan White Part C Outpatient EIS Program | 00 | 24 | HRSA | 3/19/2025 | $120,229 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AR081941 | Dissecting the structural origin of relaxation in skeletal muscle | 000 | 3 | NIH | 3/3/2025 | $510,139 |
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