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 | Issue Date FY: 2023 ( Subtotal = $20,381,707 ) (Continued on the next page) |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NR020439 | Structural Racism and Engagement of Family Caregivers in Serious Illness Care | 000 | 2 | NIH | 1/11/2023 | $726,154 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI148784 | Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant | 000 | 4 | NIH | 12/1/2022 | $819,319 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37AI067497 | Gene Regulation in Innate Immunity | 001 | 14 | NIH | 11/29/2022 | $163,500 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37AI067497 | Gene Regulation in Innate Immunity | 000 | 14 | NIH | 11/28/2022 | $327,274 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS | 55 LAKE AVE NORTH | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AI173903 | Intestinal IgA B cell receptor-specific signals integrate germinal center selection with humoral responses to commensals | 000 | 1 | NIH | 11/9/2022 | $251,250 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS | 55 LAKE AVE NORTH | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI173076 | Novel histone-binding C-type lectin receptors and their role in sterile inflammation and tissue injury | 000 | 1 | NIH | 11/9/2022 | $593,865 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI152446 | Pathobiology of VPS45 severe congenital neutropenia | 000 | 4 | NIH | 1/23/2023 | $664,274 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI141181 | A novel vaccine against multidrug-resistant gonorrhea | 000 | 5 | NIH | 12/13/2022 | $298,787 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01AI172987 | Development of targeted microbiome therapeutics and dietary interventions for potent intestinal barrier promotion to minimize GI-ARS | 000 | 1 | NIH | 12/22/2022 | $601,576 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01HL167527 | Translating post-infarct ventricular tachycardia mechanisms into a therapy | 000 | 1 | NIH | 1/9/2023 | $823,836 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI150322 | Characterizing HIV-1 Env conformations susceptible to attack by non-neutralizing antibodies | 000 | 4 | NIH | 11/8/2022 | $538,456 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK089101 | Adipose Tissue Angiogenesis and Metabolic Disease | 000 | 12 | NIH | 1/24/2023 | $507,827 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS064263 | Molecular Analysis of Neural Circuit Excitation and Inhibition | 000 | 12 | NIH | 12/2/2022 | $404,351 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK068429 | Gene Regulatory Networks in Development and Physiology | 000 | 17 | NIH | 1/6/2023 | $600,844 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI060025 | From Drosophila Immunity to Anti-Inflammatories | 001 | 19 | NIH | 12/1/2022 | $629,033 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37MH070000 | The Wingless Transduction Pathway in Synapse Development | 000 | 20 | NIH | 11/22/2022 | $376,875 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37MH070000 | The Wingless Transduction Pathway in Synapse Development | 001 | 20 | NIH | 1/20/2023 | $41,875 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01MH121599 | 2/2-Testing the impact of early screening on the long-term outcomes of children with ASD | 005 | 4 | NIH | 1/19/2023 | $22,110 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21NR020231 | Improving patient care in severe acute brain injury: a web/mobile/tablet-based communication and decision support tool for clinicians and families in the neuro-ICU | 000 | 2 | NIH | 12/12/2022 | $185,006 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01MH121599 | 2/2-Testing the impact of early screening on the long-term outcomes of children with ASD | 004 | 4 | NIH | 1/13/2023 | $62,647 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21ES031802 | Impact of circadian disruption on pancreatic cancer development and progression | 000 | 2 | NIH | 11/10/2022 | $251,250 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI150866 | Automated high throughput compound screening for broadly active anti-parasitic nematode drugs | 000 | 4 | NIH | 1/19/2023 | $636,142 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI143976 | TCR signaling control of thymic Treg selection and immune homeostasis | 000 | 4 | NIH | 11/8/2022 | $577,145 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37NS057553 | Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1 | 001 | 17 | NIH | 12/7/2022 | $588,679 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21MH129040 | A role for the interpeduncular nucleus in innate defensive behaviors | 000 | 2 | NIH | 1/17/2023 | $209,375 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35HL140017 | Embryonic origins of endothelial heterogeneity | 000 | 6 | NIH | 11/21/2022 | $904,501 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AI166281 | Development of essential research tools for sustaining global programs for the elimination of human hookworms | 000 | 3 | NIH | 1/19/2023 | $199,915 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK126804 | Extracellular protease modulation of the cilium transition zone in kidney development and disease | 000 | 2 | NIH | 12/15/2022 | $331,650 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK126804 | Extracellular protease modulation of the cilium transition zone in kidney development and disease | 001 | 2 | NIH | 1/9/2023 | $36,850 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01GM134300 | The Mechanism of Cell Size Regulation | 000 | 4 | NIH | 1/6/2023 | $301,500 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31NS122493 | The Impact of Nucleotide Modification Patterns on Therapeutic Small Interfering RNA Activity in the Central Nervous System | 000 | 2 | NIH | 1/4/2023 | $31,506 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | P40OD028116 | Nonhuman Primate Antibody Resource for Immune Cell Depletion | 001 | 4 | NIH | 12/14/2022 | $558,914 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R03AI173522 | Establishing a model of recurrent/chronic urinary tract infection in lupus-prone mice | 000 | 1 | NIH | 11/18/2022 | $83,750 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS | 55 LAKE AVE NORTH | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI158832 | Cholesterol metabolites coordinate skin barrier immunity centered on innate dermal gammadelta T cells programmed to produce IL-17 | 000 | 2 | NIH | 10/31/2022 | $707,833 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F30AI150127 | Pathogen sensing by nuclear hormone receptors in C. elegans intestinal epithelial cells | 000 | 4 | NIH | 12/20/2022 | $37,814 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01GM127776 | Structural mechanisms of sliding clamp loader ATPases | 000 | 5 | NIH | 1/13/2023 | $316,575 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS | 55 LAKE AVE NORTH | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AI173593 | Harnessing Age-Associated B cells for a Universal Influenza Vaccine for the Aged | 000 | 1 | NIH | 11/3/2022 | $251,250 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31DK129018 | Elucidating the role of hepatic mTORC2 as a key regulator of carbohydrate metabolism in non-alcoholic fatty liver disease | 000 | 2 | NIH | 12/8/2022 | $33,958 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R61NS130604 | Comprehensive Harmonization and Analysis of Case/Control Whole Genome Sequencing Data from the ALS/FTD Compute Project | 000 | 1 | NIH | 1/23/2023 | $1,630,264 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01CA269711 | Targeting the detoxification function of the enzyme KDSR for cancer therapy | 000 | 1 | NIH | 1/16/2023 | $388,828 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI147869 | Role of cell polarity regulators in HIV spreading | 000 | 4 | NIH | 12/8/2022 | $532,811 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31NS127555 | Establishing and Optimizing a Prime Editing Method in Neurons for Treatment of Rett Syndrome | 000 | 1 | NIH | 1/15/2023 | $31,518 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01HL152078 | Lung-Protective Mechanisms of Metformin in TB | 000 | 3 | NIH | 1/23/2023 | $573,857 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01MH121599 | 2/2-Testing the impact of early screening on the long-term outcomes of children with ASD | 003 | 4 | NIH | 12/23/2022 | $198,987 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K01HL163254 | ActivityChoice: A clinic-delivered implementation program to increase physical activity and decrease cardiovascular disease risk amongst cancer survivors | 000 | 1 | NIH | 12/12/2022 | $162,485 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F30CA257270 | Targeting dormant leukemia-initiating cells in T-cell acute lymphoblastic leukemia | 000 | 3 | NIH | 11/2/2022 | $33,910 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R61NS123756 | Generation of a large animal model of Sialidosis to enable future translation of novel therapeutics | 000 | 1 | NIH | 12/28/2022 | $505,640 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31CA268847 | Activation of non-apoptotic cell death by the DNA damage response | 000 | 2 | NIH | 12/22/2022 | $31,506 |
| | 2023 | 2023 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01GM137529 | Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1 | 000 | 3 | NIH | 11/15/2022 | $469,003 |
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