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 | Issue Date FY: 2025 ( Subtotal = $167,345,875 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI159314 | Altered T Cell Responses in Myalgic Enchephalomeylitis/Chronic Fatigue Syndrome (ME/CFS) | 000 | 5 | NIH | 2/14/2025 | $474,267 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AR078230 | Novel approaches to promote healing of bone loss in inflammatory arthritis | 001 | 4 | NIH | 5/22/2025 | $36,883 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AR078230 | Novel approaches to promote healing of bone loss in inflammatory arthritis | 000 | 4 | NIH | 2/17/2025 | $474,212 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NR021522 | A clinical-community partnership to understand health impacts of a food insecurity intervention | 001 | 2 | NIH | 7/1/2025 | $556,541 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI185024 | Immunobiology of a novel human DAMP receptor, its murine homolog, & their ligand | 000 | 1 | NIH | 2/24/2025 | $578,093 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37CA282805 | Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis | 001 | 2 | NIH | 5/22/2025 | $38,315 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37CA282805 | Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis | 000 | 2 | NIH | 3/7/2025 | $344,841 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AI191052 | Comprehensive analysis of epistasis in drug resistance potential of Mpro from SARS-CoV-2 | 000 | 1 | NIH | 2/1/2025 | $243,713 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01EB037025 | Synthetic RNA Switch-Based Temporal and Dose Control of in Vivo Gene Therapies | 001 | 1 | NIH | 7/3/2025 | $77,214 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01EB037025 | Synthetic RNA Switch-Based Temporal and Dose Control of in Vivo Gene Therapies | 000 | 1 | NIH | 2/26/2025 | $540,524 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM152201 | Cell Biology of Mammalian Nuclei | 001 | 2 | NIH | 4/29/2025 | $418,750 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AI189245 | Discovery of viral and host pathways that protect HIV-infected macrophages from NK cell ADCC | 000 | 1 | NIH | 1/27/2025 | $243,713 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K00DA062570 | Investigating the role of microglia molecular rhythms in the nucleus accumbens in OUD | 002 | 3 | NIH | 7/29/2025 | $100,436 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM149284 | Mechanisms of the gut-brain axis that regulate innate immunity | 001 | 3 | NIH | 5/15/2025 | $435,500 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01AI176310 | Predictive drivers of new onset, relapse, and progression of human autoimmunity in skin | 000 | 3 | NIH | 4/16/2025 | $1,248,082 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM149216 | RNA Control of Neural Function | 001 | 3 | NIH | 4/3/2025 | $714,341 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U24MH136793 | PsychENCODE Data Analysis and Coordination Center | 001 | 2 | NIH | 8/6/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U24MH136793 | PsychENCODE Data Analysis and Coordination Center | 000 | 2 | NIH | 5/14/2025 | $831,440 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01CA294209 | Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics | 000 | 2 | NIH | 7/8/2025 | $414,820 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01CA269711 | Targeting the detoxification function of the enzyme KDSR for cancer therapy | 001 | 3 | NIH | 6/9/2025 | $38,703 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01CA269711 | Targeting the detoxification function of the enzyme KDSR for cancer therapy | 000 | 3 | NIH | 1/8/2025 | $348,322 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U24HG012343 | A Comprehensive Genomic Community Resource of Transcriptional Regulation | 001 | 4 | NIH | 4/29/2025 | $97,629 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U24HG012343 | A Comprehensive Genomic Community Resource of Transcriptional Regulation | 000 | 4 | NIH | 4/10/2025 | $878,671 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AI181309 | RNA splicing factor Raver1 controls cell death, inflammation, and innateimmunity | 000 | 2 | NIH | 5/29/2025 | $835,485 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS139268 | AAV Gene Therapy for Sialidosis: from Mice to IND | 000 | 2 | NIH | 5/28/2025 | $654,844 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DA059640 | Craving-based Digital Phenotyping During MOUD Treatment | 001 | 2 | NIH | 6/23/2025 | $821,462 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K22CA282268 | New Proteomics Approaches to Study the Full Human Kinome, Inhibitor Resistance, and Kinase Degraders | 000 | 2 | NIH | 6/3/2025 | $211,918 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DA061243 | Novel roles for the circadian transcription factor NPAS2 and striatal dopamine D3 receptor signaling in diurnal fentanyl craving and relapse | 000 | 2 | NIH | 5/12/2025 | $466,181 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R21AR084644 | Precision Gene Editing on Osteogenesis Imperfecta | 000 | 2 | NIH | 8/4/2025 | $165,825 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK138198 | Influence of MHC-II polymorphisms on autoimmune T cell repertoire development and function | 000 | 2 | NIH | 6/9/2025 | $530,890 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R00HD109359 | First murine animal model and adeno-associated virus (AAV)-based gene therapy for MTATP6 mitochondrial diseases | 001 | 4 | NIH | 6/30/2025 | $245,217 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | K99CA281094 | Identifying and examining the effects of source and presentation on responses to electronic cigarette public education messages in young adult vapers and non-vapers | 000 | 2 | NIH | 1/15/2025 | $137,562 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R35GM152194 | Systems and Network-level Regulation of Cell Death | 001 | 2 | NIH | 4/30/2025 | $418,750 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DK068429 | C. elegans models of metabolism in health and disease | 002 | 19 | NIH | 6/6/2025 | $666,525 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R24AI192252 | Fungal Antigen Resources for Development of Vaccines and Diagnostics | 000 | 1 | NIH | 7/21/2025 | $1,193,457 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01CA305435 | MEDUSA(GM): an analysis platform for resolving mechanisms of action for anti-cancer drugs | 000 | 1 | NIH | 8/6/2025 | $415,491 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | F31HL180004 | Investigating the role of endothelial and fibroblastic reticular cells in lung inflammation caused by STING gain-of-function autoinflammation | 000 | 1 | NIH | 7/30/2025 | $37,577 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS145295 | Evaluating the efficiency of in vivo gene transfer to correct the molecular neuropathology causing psychiatric disease in MSUD | 000 | 1 | NIH | 7/30/2025 | $613,528 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01AI165524 | A systems immunology approach to evaluate malaria vaccine performance in endemic regions of Kenya | 000 | 4 | NIH | 2/13/2025 | $958,026 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01DA063146 | Discovery and functional characterization of long non-coding RNAs in opioid use disorder within the context of HIV at single cell resolution | 000 | 1 | NIH | 7/4/2025 | $585,975 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | T32GM159591 | Medical Scientist Training at UMCMS | 000 | 1 | NIH | 8/6/2025 | $1,003,507 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01AR086572 | Development of a long-lasting, bone-targeted gene therapy for osteogenesis imperfecta | 000 | 1 | NIH | 7/4/2025 | $667,125 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R00AR082987 | Developing a programmable siRNA-based therapeutic platform for gene silencing in the skin | 000 | 3 | NIH | 6/30/2025 | $249,000 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R37AI155901 | The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation | 000 | 5 | NIH | 2/12/2025 | $494,929 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R01NS111990 | Multi-Targeting Oligonucleotide Therapeutics for Familial and Sporadic Amyotrophic Lateral Sclerosis | 002 | 7 | NIH | 5/13/2025 | $665,737 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | U01AI168640 | Parsing cholesterol metabolite regulation of skin immunocytes in children to identify archetypes of human neonatal immune system | 000 | 4 | NIH | 2/12/2025 | $792,392 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | R00NS127857 | Dissection of Cell Type Specific Contributions to Motor Learning Circuits | 000 | 3 | NIH | 8/7/2025 | $224,100 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | P50AR080593 | Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT) | 002 | 4 | NIH | 8/7/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 55 LAKE AVE N | WORCESTER | MA | 01655-0002 | WORCESTER | USA | P50AR080593 | Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT) | 001 | 4 | NIH | 7/15/2025 | $1,495,911 |
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