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FUNCTION OF THE GLI GENES IN SONIC HEDGEHOG SIGNALING

Award Number: R01NS037352
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/20/1998
PERIOD OF PERFORMANCE END DATE: 04/30/2008

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FUNCTION OF THE GLI GENES IN SONIC HEDGEHOG SIGNALING - DESCRIPTION (provided by applicant): In this renewal project we propose to continue our research on the functions of the Sonic hedgehog (Shh)-Gli pathway in neural development during embryonic, perinatal and adult stages using the mouse as an experimental model. Specifically, we will study the role of Gli protein function in Nestin progenitors during mouse brain growth and patterning, focusing on their role in the neocortex. We will also investigate Shh-Gli function in neural stem cells, from both the embryonic neocortex and the postnatal and adult subventricular zone of the lateral ventricle. The results of our proposed research will help in understanding how this important signaling pathway regulates the growth and patterning of the brain, with special emphasis placed on the neocortex, a preeminent structure in human brain function. Our ongoing research on how progenitor cells respond to Shh-Gli function will help in understanding how the brain is formed, which will also lead to an understanding of the bases of a number of mental deficits. Indeed, our findings will likely shed light into the possible mental deficits that patients with viable forms of holoprosencephaly (a disease that can arise from defective SHH signaling) may display. In addition, the knowledge of how the SHH-GLI pathway affects brain precursors will help our understanding of how brain tumors arise, an area of research covered under a different, yet related, project in the laboratory.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2005	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/20/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $321,853 )
2007	2007	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	8/28/2007	NON-COMPETING CONTINUATION	$321,853
														Subtotal = $321,853

Issue Date FY: 2006 ( Subtotal = $328,665 )
2006	2006	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	9/18/2006	NON-COMPETING CONTINUATION	$328,665
														Subtotal = $328,665

Issue Date FY: 2005 ( Subtotal = $349,353 )
2005	2005	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/12/2005	NON-COMPETING CONTINUATION	$349,353
														Subtotal = $349,353

Issue Date FY: 2004 ( Subtotal = $310,635 )
2004	2004	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	9/22/2004	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$310,635
														Subtotal = $310,635

Issue Date FY: 2003 ( Subtotal = $437,343 )
2003	2003	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/31/2003	COMPETING CONTINUATION	$437,343
														Subtotal = $437,343

Issue Date FY: 2002 ( Subtotal = $279,053 )
2002	2002	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/28/2002	NON-COMPETING CONTINUATION	$279,053
														Subtotal = $279,053

Issue Date FY: 2001 ( Subtotal = $270,957 )
2001	2001	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/11/2001	NON-COMPETING CONTINUATION	$270,957
														Subtotal = $270,957

Issue Date FY: 2000 ( Subtotal = $263,091 )
2000	2000	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	CHE	Biological Basis Research in the Neurosciences	000	3	4/20/2000	NON-COMPETING CONTINUATION	$263,091
														Subtotal = $263,091

Issue Date FY: 1999 ( Subtotal = $325,460 )
1999	1999	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	CHE	Biological Basis Research in the Neurosciences	001	2	4/30/1999	SUPPLEMENT FOR EXPANSION	$40,000
1999	1999	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	CHE	Biological Basis Research in the Neurosciences	000	2	3/3/1999	NON-COMPETING CONTINUATION	$285,460
														Subtotal = $325,460

Issue Date FY: 1998 ( Subtotal = $247,940 )
1998	1998	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	CHE	Biological Basis Research in the Neurosciences	000	1	2/13/1998	NEW	$247,940
														Subtotal = $247,940

Grand Total All Awards = $3,134,350

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FUNCTION OF THE GLI GENES IN SONIC HEDGEHOG SIGNALING

Award Number: R01NS037352

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/20/1998

PERIOD OF PERFORMANCE END DATE: 04/30/2008

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