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FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (FNIRI)

Award Number: R01NS036633
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/1998
PERIOD OF PERFORMANCE END DATE: 07/31/2006

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FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (FNIRI) - DESCRIPTION (Provided by Applicant): Significant progress over three and a half years of support on the three proposed aims has enabled: 1) in-depth cognitive function studies (over 2,000 studies) with seven high school subjects in Year 3. The preferred prefrontal imaging modality was developed and tested in Year 2 (600 validation studies) with the result that maximal optical signals in fruitful prefrontal voxels are sharply imaged when the "difficulty matches ability" in anagram solutions using a time multiplex pulsed light system (ACTM). This provides a fast, safe, and economical brain function NIR imager. 2) Quantitative brain oximetry requires measures of tissue optical properties for which the IQ oximeter has been tested on piglet models and the brain oxygen tissue value is found to be near the average of arterial and venous values. 3) Thick hair oximetry has been solved by higher laser power (FDA Class 3) and by intercalculating light fibers inserted through ferrules in a rigid helmet. This progress affords a sound basis for the design of a wearable, portable brain function imager which will be constructed and tested on various age groups to further validate difficulty/ability match and to extrapolate to younger groups where testing is more difficulty due to disattention. Quantitative brain tissue oximetry will now output arterial and venous values and, in animal models, wifi be correlated with corresponding localized 3-D images of the mitochondrial redox state in hypoxia, in order to correlate critical desaturation of hemoglobin and mitochondrial hypoxia in the piglet brain model and serve as a warning signal in evaluating stroke-induced hypoxias in neonates. In order to explore the time range of optical signals beyond vasomotor and metabolic effects, a fast (15 Hz) high localized (approximately 1 mm3) phased array system with sequential lock-in?s will provide very sensitive phase measurements. This frequency domain system will be used to evaluate the feasibility of detection of light scattering changes due to iterated visual responses in the occipital region with a go/no-go point in Year 3. These projects represent logical continuations of current activities into new and related researches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $363,375 )
2005	2005	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/11/2005	NON-COMPETING CONTINUATION	$363,375
														Subtotal = $363,375

Issue Date FY: 2004 ( Subtotal = $363,375 )
2004	2004	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	9/15/2004	NON-COMPETING CONTINUATION	$363,375
														Subtotal = $363,375

Issue Date FY: 2003 ( Subtotal = $363,375 )
2003	2003	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/21/2003	NON-COMPETING CONTINUATION	$363,375
														Subtotal = $363,375

Issue Date FY: 2002 ( Subtotal = $363,375 )
2002	2002	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/20/2002	COMPETING CONTINUATION	$363,375
														Subtotal = $363,375

Issue Date FY: 2001 ( Subtotal = $174,098 )
2001	2001	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/3/2001	NON-COMPETING CONTINUATION	$174,098
														Subtotal = $174,098

Issue Date FY: 2000 ( Subtotal = $185,240 )
2000	2000	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Biological Basis Research in the Neurosciences	000	3	8/17/2000	NON-COMPETING CONTINUATION	$177,123
2000	2000	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Biological Basis Research in the Neurosciences	001	2	11/30/1999	SUPPLEMENT FOR EXPANSION	$8,117
														Subtotal = $185,240

Issue Date FY: 1999 ( Subtotal = $163,998 )
1999	1999	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Biological Basis Research in the Neurosciences	000	2	9/3/1999	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$163,998
														Subtotal = $163,998

Issue Date FY: 1998 ( Subtotal = $172,310 )
1998	1998	UNIVERSITY CITY SCIENCE CENTER	3624 MARKET STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/17/1998	NEW	$172,310
														Subtotal = $172,310

Grand Total All Awards = $2,149,146

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FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (FNIRI)

Award Number: R01NS036633

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/1998

PERIOD OF PERFORMANCE END DATE: 07/31/2006

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