Sunday, August 31, 2025 8/31/2025

Education and employment support for HIV prevention in young adults (ENSPIRE)

Award Number: R01MD016815
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2027

Group Awards By:

View Award Description

Education and employment support for HIV prevention in young adults (ENSPIRE) - Abstract: This study evaluates the effectiveness of a combination intervention providing education, employment support, resources, and mentoring on uptake of HIV prevention medication and behaviors in U.S. young adults. Approximately 1.2 million Americans are currently living with HIV, and many more are at risk of HIV infection. While new HIV diagnoses have declined in recent years, an estimated 38,000 Americans are newly diagnosed each year. Young adults represent a growing proportion of new HIV diagnoses in the U.S. and are more likely to acquire HIV infection compared to older adults due to limited education on prevention of sexually transmitted infections (STI), higher rates of sexual risk behaviors, and lower access to HIV prevention therapies. Young adults also face higher rates of economic hardship, such as unemployment, job instability, homelessness, or low wage – which are associated with higher rates of HIV. Pre-exposure prophylaxis (PrEP) is a medication that can prevent HIV infection in individuals who do not have HIV but are at risk of contracting it. Research has shown that PrEP is highly effective in preventing HIV transmission through sexual activity among individuals who are at risk of HIV infection. Yet, young adults make-up a small proportion of PrEP users in the United States. Barriers to uptake of PrEP are often economic in nature if potential users are uninsured or if, even with health insurance, potential users lack income to pay for out-of-pocket expenses relating to medications, lab monitoring, or travel to clinics. In addition, young adults experiencing economic hardship are often unaware of the benefits of PrEP, how to access it, how to pay for it, and how to discuss HIV prevention medications and behaviors with their sex partners or healthcare providers. Therefore, interventions that provide education on HIV prevention and that provide support to enhance access to employment and cost-assistance programs are needed. This study will randomize U.S. young adults to an experimental group that will receive HIV prevention education (i.e., PrEP, condomless sex), economic resources, job announcements, job readiness training, and employment mentoring or to a control group that will receive job announcements only. We will recruit sexually active young adults, aged 18 to 24, who are experiencing economic hardship. The specific aims are to: (1) evaluate the effectiveness of the intervention on condomless sex and PrEP initiation, as well as participants’ economic stability as achieved by enhanced employment; (2) assess heterogeneity of intervention effects by sex and by peer support; and (3) examine mechanisms of change and component experiences using statistical and qualitative methods.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $692,975 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	001	5	4/17/2025	NON-COMPETING CONTINUATION	$692,975
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	000	4	3/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $692,975

Issue Date FY: 2024 ( Subtotal = $713,379 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	001	4	5/29/2024	NON-COMPETING CONTINUATION	$49,936
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	000	4	3/24/2024	NON-COMPETING CONTINUATION	$642,042
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	002	4	6/12/2024	NON-COMPETING CONTINUATION	$21,401
														Subtotal = $713,379

Issue Date FY: 2023 ( Subtotal = $712,493 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	004	3	5/14/2023	NON-COMPETING CONTINUATION	$712,493
2023	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Minority Health and Health Disparities Research	000	1	12/7/2022	NEW	-$791,988
2023	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Minority Health and Health Disparities Research	002	1	4/10/2023	NEW	-$15,462
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	001	2	12/7/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$791,988
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Minority Health and Health Disparities Research	003	2	4/10/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$15,462
														Subtotal = $712,493

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Minority Health and Health Disparities Research	000	1	1/12/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $807,450 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Minority Health and Health Disparities Research	000	1	7/8/2021	NEW	$807,450
														Subtotal = $807,450

Grand Total All Awards = $2,926,297

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Education and employment support for HIV prevention in young adults (ENSPIRE)

Award Number: R01MD016815

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer