Wednesday, February 5, 2025 2/5/2025

High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics Screening

Award Number: R01HL166522
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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In order to accurately determine the volume concentrations of different molecular components of the vascularized thrombosis organ-on-a-chip models developed in the parent grant, the proposed supplement application will focus on building and testing a new imaging technology, which can acquire the experimental absorption spectra of various tissue components. Specifically, Colton McGarraugh at the Yao lab at Duke University will develop the ‘photoacoustic fingerprinting’ method, which will be used to identify different concentrations of varying molecules by comparing a variety of different photoacoustic measurements at different wavelengths and their ‘matched’ models in the simulated library. This new technology will have the potential to identify different proteins and larger molecules in the engineered tissues of the organ-on-a-chip system beyond hemoglobin, such as fat, proteins, fibrin, platelets, and glucose, and thus will enhance the technical capabilities of the photoacoustic imaging technology proposed in the parent grant.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $636,048 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	000	3	12/12/2024	NON-COMPETING CONTINUATION	$556,579
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	001	3	12/16/2024	SUPPLEMENT FOR EXPANSION	$79,469
														Subtotal = $636,048

Issue Date FY: 2024 ( Subtotal = $659,939 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	002	2	6/8/2024	NON-COMPETING CONTINUATION	$49,907
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	001	2	5/7/2024	SUPPLEMENT FOR EXPANSION	$48,578
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	000	2	11/10/2023	NON-COMPETING CONTINUATION	$561,454
														Subtotal = $659,939

Issue Date FY: 2023 ( Subtotal = $635,893 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Blood Diseases and Resources Research	000	1	12/15/2022	NEW	$635,893
														Subtotal = $635,893

Grand Total All Awards = $1,931,880

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High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics Screening

Award Number: R01HL166522

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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