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Inter-organ crosstalk and the regulation of lipid metabolism

Award Number: R01GM154435
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Inter-organ crosstalk and the regulation of lipid metabolism - PROJECT SUMMARY Metabolic regulation is a complex and essential process for the survival of multicellular organisms, necessitating the coordination of various cell types and organ systems to adapt to changes in nutrient availability. Stressors, such as fasting, cold exposure, and exercise, further challenge this delicate balance and require efficient inter-organ communication to ensure optimal energy utilization. Adipocytes, as the primary site of energy storage, play a crucial role in providing fatty acids for tissues like the liver during such conditions. The goal of this proposed research is to gain a comprehensive in vivo understanding of the dynamic changes that occur in the liver upon activation of adipocyte lipolysis, with a specific focus on the impact of the glucocorticoid receptor (GR) pathway. This proposed research aims to investigate the intricate metabolic adaptations associated with adipocyte lipolysis and its influence on the glucocorticoid receptor (GR) pathway in the liver. Through a comprehensive in vivo approach, we will explore the impact of adipocyte lipolysis on the Corticotropin-Releasing Hormone (CRH) within the Hypothalamic-Pituitary-Adrenal (HPA) axis and its potential link to stress responses. We will also delve into the role of the hepatic glucocorticoid receptor in regulating fat oxidation and ketogenesis, crucial processes for energy utilization. Additionally, we will investigate whether the induction of Plin5 expression by GR activation promotes ketogenesis by facilitating interactions between mitochondria and lipid droplets. This proposal will also implement a learning module to train students in genetic engineering and teach them about CRISPR-Cas9 system used for biomedical research. The research seeks to advance our understanding of these intricate metabolic pathways and provide insights into stress-related metabolic regulation, with potential implications for therapeutic interventions in metabolic disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $533,171 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	5/8/2026	NEW	$533,171
														Subtotal = $533,171

Grand Total All Awards = $533,171

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Inter-organ crosstalk and the regulation of lipid metabolism

Award Number: R01GM154435

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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