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The role of superoxide dismutase SOD-1 in microbe-gut-brain interaction

Award Number: R01GM131156
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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The role of superoxide dismutase SOD-1 in microbe-gut-brain interaction - Gut microbes play an important role in regulating host physiology and metabolism. Recent studies indicate that gut microbes affect memory formation and neurodegenerative disease manifestation. However, it is not fully understood how gut microbes influence gut–brain communication. The nematode C. elegans has a relatively simple nervous system and will readily ingest microbes from a petri dish. Therefore, C. elegans is a well-established model organism for studying the neural basis of behaviors and host–microbe interactions. By combining the two areas of research, we recently discovered that superoxide dismutase-1 (SOD-1), an enzyme that converts superoxide to less harmful peroxide, acts as a reactive sensor of reactive oxygen species in the nervous system and regulates the behavioral response to microbes. Our data indicate a previously unknown function of SOD-1 and suggest a potential role for SOD-1 in regulating microbe-induced gut–brain communication. In aim 1, we will determine how bacteria activate SOD-1. In aim 2, we will determine whether a neuropeptide functions as a signaling molecule between the gut and the nervous system to modulate the SOD-1 dependent response. In aim 3, we will define how SOD-1 and glutamatergic signaling regulate behavioral response to microbes. The proposed work will advance our knowledge in several ways. Our genetic model will open up a new research area for understanding the microbe-induced communication at the gut–brain axis. In addition, the proposed experiments will unveil new regulatory pathways of SOD-1. Our results may help to elucidate the underlying mechanisms of gut dysbiosis among elderly adults and patients with neurodegenerative diseases and may lead to the identification of potential therapeutic target.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	000	6	6/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $338,100 )
2023	2023	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	000	6	5/12/2023	NON-COMPETING CONTINUATION	$338,100
														Subtotal = $338,100

Issue Date FY: 2022 ( Subtotal = $338,100 )
2022	2022	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	000	5	5/19/2022	NON-COMPETING CONTINUATION	$338,100
														Subtotal = $338,100

Issue Date FY: 2021 ( Subtotal = $338,100 )
2021	2021	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	000	4	5/7/2021	NON-COMPETING CONTINUATION	$338,100
														Subtotal = $338,100

Issue Date FY: 2020 ( Subtotal = $328,510 )
2020	2020	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	002	3	5/1/2020	NON-COMPETING CONTINUATION	$338,100
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	003	1	8/30/2020	NEW	$0
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	3/30/2020	NEW	-$285,444
2020	2019	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	004	2	8/30/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2019	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Biomedical Research and Research Training	001	2	4/1/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$275,854
														Subtotal = $328,510

Issue Date FY: 2019 ( Subtotal = $316,400 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	7/19/2019	NEW	$316,400
														Subtotal = $316,400

Grand Total All Awards = $1,659,210

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The role of superoxide dismutase SOD-1 in microbe-gut-brain interaction

Award Number: R01GM131156

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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