The goal of this proposal is to investigate the role of a novel Telomere associated protein that
we termed TZAP in telomere homeostasis. Telomeres are essential nucleoprotein structures
that cap chromosome ends. Alterations in telomere function are associated with various human
diseases including cancer, premature aging, dyskeratosis congenita, aplastic anemia, and
idiopathic pulmonary fibrosis. Our preliminary data show that TZAP is a novel telomere specific
binding protein that is involved in telomere length homoeostasis. Several questions remain to be
addressed to define the role of this novel telomere associated protein in telomere homeostasis.
To address this questions, we have devised a research proposal that will define the mechanism
of TZAP binding to telomeres, its role on telomere length regulation and the impact of its
depletion in respect to genome stability and tissue homoeostasis.