Sunday, May 11, 2025 5/11/2025

Hotspots_COVID Supplement II

Award Number: R01GM109718
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Hotspots_COVID Supplement II - Summary This application is in response to the urgent need to understand the epidemiological impact of non-uniform uptake of the newly approved SARS-CoV-2 vaccine for children in the US. Despite the continuing infections and hospitalizations due to COVID-19, there is no doubt that vaccination has led to significantly improved outcomes. With the recent approval of vaccinations for young children, we now have a real opportunity for controlling COVID-19. However, several factors could pose roadblocks towards this goal: opposition to the vaccine and other policies such as masking, occupancy limits and testing (especially in schools), new variants and waning immunity. As a result, the risk for even well vaccinated subgroups, such as seniors, could increase in the coming months. Modeling this increased risk, and finding the most vulnerable subgroups is a very challenging problem with high public health impact. Our project will develop a rigorous data and model driven approach to identify and characterize the most vulnerable subgroups, and study strategies for mitigating their risk; this approach will be evaluated for Virginia. Team members have been supporting the Virginia Dept of Health’s (VDH) COVID-19 response since the start of the pandemic, and have novel high resolution datasets and domain expertise through this collaboration. We will extend a detailed, age-stratified agent based model (ABM) for SARS-CoV-2 transmis- sion in Virginia by incorporating detailed datasets on vaccine hesitancy, immunization, and school mixing and interventions. The calibration, simulation and analysis of such an ABM is difficult in itself due to its large scale. Using such a model to identify the most vulnerable populations in such large models is computationally very challenging, and has not been done before. An innovative as- pect of the project is the combination of tools from AI and high performance computing with large scale ABMs for such problems. The project will build significantly on tools and models developed by team members as part of the parent grant.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$406 )
2024	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	9	9/24/2024	SUPPLEMENT FOR EXPANSION	-$205
2024	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	9	9/24/2024	NON-COMPETING CONTINUATION	-$200
														Subtotal = -$406

Issue Date FY: 2022 ( Subtotal = $637,593 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	9	6/27/2022	NON-COMPETING CONTINUATION	$31,461
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	9	4/6/2022	SUPPLEMENT FOR EXPANSION	$323,000
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	9	3/18/2022	NON-COMPETING CONTINUATION	$283,132
														Subtotal = $637,593

Issue Date FY: 2021 ( Subtotal = $332,315 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	8	4/27/2021	NON-COMPETING CONTINUATION	$321,062
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	003	8	7/1/2021	SUPPLEMENT FOR EXPANSION	$11,253
2021	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	7	4/1/2021	COMPETING CONTINUATION	$9,994
2021	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	6	4/1/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$9,994
														Subtotal = $332,315

Issue Date FY: 2020 ( Subtotal = $706,126 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	7	6/18/2020	COMPETING CONTINUATION	$324,178
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	003	7	7/3/2020	SUPPLEMENT FOR EXPANSION	$381,948
2020	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	000	5	2/23/2020	NON-COMPETING CONTINUATION	-$1
2020	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	6	2/23/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
														Subtotal = $706,126

Issue Date FY: 2019 ( Subtotal = $11,437 )
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	002	5	9/5/2019	NON-COMPETING CONTINUATION	$225,876
2019	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	006	6	9/9/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$387,119
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	005	5	9/9/2019	SUPPLEMENT FOR EXPANSION	-$149,807
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	001	5	5/10/2019	SUPPLEMENT FOR EXPANSION	-$149,807
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	004	5	9/9/2019	NON-COMPETING CONTINUATION	-$225,875
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	003	5	9/5/2019	SUPPLEMENT FOR EXPANSION	$149,807
2019	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	000	5	5/10/2019	NON-COMPETING CONTINUATION	-$225,876
														Subtotal = $11,437

Issue Date FY: 2018 ( Subtotal = $499,916 )
2018	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	001	5	8/31/2018	SUPPLEMENT FOR EXPANSION	$149,807
2018	2018	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	000	5	5/11/2018	NON-COMPETING CONTINUATION	$350,109
														Subtotal = $499,916

Issue Date FY: 2017 ( Subtotal = $350,797 )
2017	2017	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW, SUITE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	001	4	6/5/2017	NON-COMPETING CONTINUATION	$35,080
2017	2017	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW, SUITE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Biomedical Research and Research Training	000	4	5/15/2017	NON-COMPETING CONTINUATION	$315,717
														Subtotal = $350,797

Issue Date FY: 2016 ( Subtotal = $351,445 )
2016	2016	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	460 TURNER STREET, SUITE 306	BLACKSBURG	VA	24060	MONTGOMERY	USA	Biomedical Research and Research Training	000	3	5/6/2016	NON-COMPETING CONTINUATION	$351,445
														Subtotal = $351,445

Issue Date FY: 2015 ( Subtotal = $352,057 )
2015	2015	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	460 TURNER STREET, SUITE 306	BLACKSBURG	VA	24060	MONTGOMERY	USA	Biomedical Research and Research Training	000	2	5/12/2015	NON-COMPETING CONTINUATION	$352,057
														Subtotal = $352,057

Issue Date FY: 2014 ( Subtotal = $352,634 )
2014	2014	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	460 TURNER STREET, SUITE 306	BLACKSBURG	VA	24060	MONTGOMERY	USA	Biomedical Research and Research Training	000	1	7/30/2014	NEW	$352,634
														Subtotal = $352,634

Grand Total All Awards = $3,593,914

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Hotspots_COVID Supplement II

Award Number: R01GM109718

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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