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Catalytic C−C Activation/Functionalization of Ketones and Amides

Award Number: R01GM109054
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Catalytic C−C Activation/Functionalization of Ketones and Amides - Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C) bond activation for developing new, general and synthetically useful methods. Our objective, in the proposed funding period, is to focus on C−C activation and functionalization of ketones and amides, as they are easily accessible and widely found in feedstock chemicals. Through harnessing the power of transition-metal catalysts, sometimes assisted by an organic activator, a suite of new, selective, and efficient methods involving C−C activation of ketones and amides will be developed. Specifically, we will: (i) explore new C−C activation modes that allow rapid access to complex sp3-rich ring systems, (ii) enable a novel and broadly applicable cross-coupling reaction via deacylation of unstrained ketones, and (iii) allow selective activation of α-C−C bonds of unstrained amides. The research proposed is expected to offer an atom-economical approach for preparing novel complex sp3-rich molecular scaffolds from readily available substrates, which should help to access greater chemical space beyond the “flatland”. It is also expected to simplify synthesis through new strategies for bond disconnections and to enable skeletal editing of complex molecules under redox-neutral conditions, capitalizing on C−C activation/functionalization of ketones and amides.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $334,335 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	11	6/25/2024	NON-COMPETING CONTINUATION	$334,335
2024	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	003	10	9/27/2024	COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	9	9/27/2024	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	002	9	9/27/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $334,335

Issue Date FY: 2023 ( Subtotal = $334,335 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	10	7/20/2023	COMPETING CONTINUATION	$334,335
2023	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	9	7/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $334,335

Issue Date FY: 2022 ( Subtotal = $393,431 )
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	9	6/23/2022	SUPPLEMENT FOR EXPANSION	$88,268
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	9	6/22/2022	NON-COMPETING CONTINUATION	$305,163
														Subtotal = $393,431

Issue Date FY: 2021 ( Subtotal = $386,623 )
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	8	7/19/2021	SUPPLEMENT FOR EXPANSION	$80,912
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	8	7/7/2021	NON-COMPETING CONTINUATION	$305,711
														Subtotal = $386,623

Issue Date FY: 2020 ( Subtotal = $306,244 )
2020	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	002	7	6/16/2020	NON-COMPETING CONTINUATION	$306,244
2020	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	6	5/6/2020	COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	5	5/6/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $306,244

Issue Date FY: 2019 ( Subtotal = $419,392 )
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	6	7/30/2019	SUPPLEMENT FOR EXPANSION	$112,630
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	6	5/27/2019	COMPETING CONTINUATION	$306,762
														Subtotal = $419,392

Issue Date FY: 2018 ( Subtotal = $290,727 )
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	5	6/27/2018	NON-COMPETING CONTINUATION	$290,727
														Subtotal = $290,727

Issue Date FY: 2017 ( Subtotal = $290,727 )
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	003	4	6/19/2017	NON-COMPETING CONTINUATION	$290,727
2017	2016	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	002	3	1/19/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$361,058
2017	2014	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	001	2	1/19/2017	NON-COMPETING CONTINUATION	-$286,094
2017	2013	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	1	1/19/2017	NEW	-$74,964
														Subtotal = $290,727

Issue Date FY: 2016 ( Subtotal = $252,688 )
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	3	8/11/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$252,688
2016	2014	UNIVERSITY OF TEXAS AT AUSTIN	101 EAST 27TH STREET	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	001	2	8/11/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $252,688

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2014	UNIVERSITY OF TEXAS AT AUSTIN	101 EAST 27TH STREET	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	2	9/2/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $286,094 )
2014	2014	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Biomedical Research and Research Training	000	2	6/20/2014	NON-COMPETING CONTINUATION	$286,094
														Subtotal = $286,094

Issue Date FY: 2013 ( Subtotal = $286,094 )
2013	2013	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Biomedical Research and Research Training	000	1	9/27/2013	NEW	$286,094
														Subtotal = $286,094

Grand Total All Awards = $3,580,690

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Catalytic C−C Activation/Functionalization of Ketones and Amides

Award Number: R01GM109054

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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