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The WikiPathways Project: At the Intersection of Big Data and Researcher Knowledge

Award Number: R01GM100039
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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The WikiPathways Project: At the Intersection of Big Data and Researcher Knowledge - PROJECT SUMMARY WikiPathways aims to capture the full diversity of biological pathway information as both human readable diagrams and computational models. Our pioneering approach, especially among biomedical databases, has been to dramatically decentralize collection and curation, opening the process up to any interested researcher or citizen scientist, while maintaining multiple tiers of quality assurance prior to distribution. The approach is working. In the midst of an already exceptional growth curve, we are now targeting new sources of published pathway information yet to be modeled by any other database and new onramps for researchers to become contributors. Further, we intend to make pathway information more accessible and relevant by supplying multiple image and data formats, and also by taking the time to integrate our pathway data with public and user datasets, semantic resources, publications, and bioinformatics workflows. These new inputs and output also depend on stable, scalable infrastructure, thus our aims: 1. To target new content streams from published figures and consortia, while also expanding the potential base of contributors and curators through innovative training systems and improved web-based pathway modeling tools. 2. To enhance research results through the integration of pathway information with specific datasets, resources and workflows, enabling custom visualizations, semantic queries, and enrichment analyses. 3. To provide researchers with a reliable set of services through specific software hardening and modularizing steps that will support scalable and sustainable hardware options. Over the next 5 years, we will redefine (yet again) what is expected from a pathway database by capturing the full diversity of biological pathway models and providing dynamic and integrated views of these pathway data. Our aim to include more researchers in our collaborative pathway collection and curation process serves the database, and also will expose researchers to the direct benefits of open science practices. Ultimately, our goal remains to support and enhance efforts across all areas of biomedical and disease research. A comprehensive collection of pathway models continuously maintained by an open, collaborative process will provide valuable context and connections for diverse datasets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	9	10/30/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $388,928 )
2020	2020	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	9	5/1/2020	NON-COMPETING CONTINUATION	$388,928
														Subtotal = $388,928

Issue Date FY: 2019 ( Subtotal = $388,928 )
2019	2019	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	8	5/1/2019	NON-COMPETING CONTINUATION	$388,928
														Subtotal = $388,928

Issue Date FY: 2018 ( Subtotal = $388,928 )
2018	2018	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	002	7	4/25/2018	NON-COMPETING CONTINUATION	$388,928
2018	2017	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	6	12/2/2017	COMPETING CONTINUATION	$226,661
2018	2016	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	12/2/2017	EXTENSION WITH OR WITHOUT FUNDS	-$226,661
														Subtotal = $388,928

Issue Date FY: 2017 ( Subtotal = $388,928 )
2017	2017	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	6	7/24/2017	COMPETING CONTINUATION	$388,928
2017	2016	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	7/19/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $388,928

Issue Date FY: 2016 ( Subtotal = $375,400 )
2016	2016	J DAVID GLADSTONE INSTITUTES	P.O. BOX 419100	SAN FRANCISCO	CA	94141	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	6/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$375,400
														Subtotal = $375,400

Issue Date FY: 2015 ( Subtotal = $375,400 )
2015	2015	J DAVID GLADSTONE INSTITUTES	P.O. BOX 419100	SAN FRANCISCO	CA	94141	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	4	5/14/2015	NON-COMPETING CONTINUATION	$375,400
														Subtotal = $375,400

Issue Date FY: 2014 ( Subtotal = $368,384 )
2014	2014	J DAVID GLADSTONE INSTITUTES	P.O. BOX 419100	SAN FRANCISCO	CA	94141	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	3	5/27/2014	NON-COMPETING CONTINUATION	$368,384
														Subtotal = $368,384

Issue Date FY: 2013 ( Subtotal = $352,105 )
2013	2013	J DAVID GLADSTONE INSTITUTES	P.O. BOX 419100	SAN FRANCISCO	CA	94141	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	2	5/30/2013	NON-COMPETING CONTINUATION	$352,105
														Subtotal = $352,105

Issue Date FY: 2012 ( Subtotal = $368,384 )
2012	2012	J DAVID GLADSTONE INSTITUTES	P.O. BOX 419100	SAN FRANCISCO	CA	94141	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	1	8/24/2012	NEW	$368,384
														Subtotal = $368,384

Grand Total All Awards = $3,395,385

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The WikiPathways Project: At the Intersection of Big Data and Researcher Knowledge

Award Number: R01GM100039

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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