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 | Issue Date FY: 2025 ( Subtotal = $49,322,369 ) (Continued on the next page) |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG071697 | Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease | 001 | 5 | NIH | 9/4/2025 | $65,386 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG071697 | Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease | 000 | 5 | NIH | 5/12/2025 | $735,586 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL163268 | Small molecule therapeutic for calcific aortic valve disease | 000 | 3 | NIH | 4/25/2025 | $718,293 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033362 | Self-Assembling Spike-EBR Nanoparticles as a Vaccine Platform Technology Against SARS-CoV-2 and Future Pandemic Coronaviruses | 005 | 4 | NIH | 8/8/2025 | $1 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL163268 | Small molecule therapeutic for calcific aortic valve disease | 001 | 3 | NIH | 7/3/2025 | $79,811 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033362 | Self-Assembling Spike-EBR Nanoparticles as a Vaccine Platform Technology Against SARS-CoV-2 and Future Pandemic Coronaviruses | 005 | 4 | NIH | 8/8/2025 | $944,999 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG085468 | Study Alzheimer's Disease Protective APOE Variants | 001 | 2 | NIH | 8/4/2025 | $75,308 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG085468 | Study Alzheimer's Disease Protective APOE Variants | 000 | 2 | NIH | 11/21/2024 | $847,228 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AI183286 | Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV | 000 | 2 | NIH | 4/10/2025 | $891,217 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033381 | Molecular tools to decipher communication across the blood-brain barrier | 001 | 5 | NIH | 8/15/2025 | $1 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033381 | Molecular tools to decipher communication across the blood-brain barrier | 001 | 5 | NIH | 8/15/2025 | $944,999 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS142087 | Understanding and Treating NAXD Deficiency Using Vitamin B3-Based Approaches | 000 | 1 | NIH | 7/25/2025 | $574,921 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG076647 | Study Susceptibility and Resistance to ApoE4 in Alzheimer's Disease | 000 | 2 | NIH | 7/29/2025 | $861,422 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL179702 | Mechanisms of Oxygen Toxicity | 000 | 1 | NIH | 8/19/2025 | $731,827 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R35NS143067 | Neurovascular Interactions: Mechanisms, Imaging, Therapeutics | 000 | 1 | NIH | 8/14/2025 | $1,375,478 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS124848 | Dissecting the Etiology of The Lewy Body Dementias | 000 | 2 | NIH | 8/15/2025 | $764,836 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AI191341 | Transforming HIV vaccine design with a hybrid technology that leverages features of mRNA and protein nanoparticle platforms | 000 | 1 | NIH | 9/26/2025 | $3,559,750 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32HD114427 | Transcriptional variation in human milk | 001 | 2 | NIH | 6/6/2025 | $1,236 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32HD114427 | Transcriptional variation in human milk | 000 | 2 | NIH | 12/19/2024 | $77,284 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HG013736 | Methods to build and annotate tissue atlases using spatial genomic data | 000 | 2 | NIH | 9/18/2025 | $829,659 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R37AI109593 | Modulating Stochastic Gene Expression for Cell-fate Control and Therapeutics | 003 | 9 | NIH | 3/26/2025 | $1,927,847 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R21HL173710 | Targeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery Vehicles | 000 | 2 | NIH | 3/31/2025 | $283,500 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R21AI184073 | Targeting CD127-expressing tissue reservoir cells as a strategy for HIV cure | 000 | 2 | NIH | 7/23/2025 | $252,348 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS128909 | Elucidating microvascular contributions to cognitive impairment at single-cell resolution | 005 | 4 | NIH | 6/27/2025 | $1,165,270 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS121287 | Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity | 000 | 4 | NIH | 11/21/2024 | $371,162 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | UM1AI164559 | HOPE - HIV Obstruction by Programmed Epigenetics | 000 | 5 | NIH | 7/18/2025 | $4,951,244 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG092683 | Harnessing novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease | 000 | 1 | NIH | 6/11/2025 | $817,357 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG072052 | C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | 001 | 3 | NIH | 6/10/2025 | $56,699 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG072052 | C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | 000 | 3 | NIH | 4/1/2025 | $637,876 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | K01HL173644 | Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations | 000 | 2 | NIH | 8/4/2025 | $179,280 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG085961 | Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model | 000 | 2 | NIH | 11/19/2024 | $76,756 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG085961 | Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model | 001 | 2 | NIH | 5/29/2025 | $0 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01DA059551 | Sorting and Sequencing Latent Reservoirs in HIV+ Opioid Users | 001 | 3 | NIH | 8/11/2025 | $1,557,466 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R37AI083139 | Role of Factor Acetylation in the Regulation of HIV Transcription | 002 | 16 | NIH | 6/23/2025 | $737,100 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | K99HL177318 | Uncovering the Mechanisms that Enable Cardiac Progenitors to Build the Linear Heart Tube | 000 | 1 | NIH | 7/9/2025 | $134,998 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL057181 | Cardiogenesis: Molecular Mechanisms | 002 | 30 | NIH | 5/27/2025 | $803,250 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL057181 | Cardiogenesis: Molecular Mechanisms | 001 | 28 | NIH | 2/19/2025 | $803,250 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AT013724 | A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies | 001 | 1 | NIH | 8/14/2025 | $20,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AT013724 | A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies | 001 | 1 | NIH | 8/14/2025 | -$20,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AT013724 | A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies | 000 | 1 | NIH | 8/12/2025 | $1,321,208 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | K01AG083732 | Machine Learning Approaches for Behavioral Phenotyping of Humanized Knock-in Models of Alzheimer's Disease | 000 | 3 | NIH | 5/16/2025 | $150,630 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01DK131526 | Multiomics characterization, induction, and elimination of the HIV gut reservoir | 000 | 4 | NIH | 4/29/2025 | $724,238 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG082460 | Understanding how neuronal glucose metabolism changes in AD due to ApoE4 | 001 | 3 | NIH | 6/23/2025 | $1,428 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG082460 | Understanding how neuronal glucose metabolism changes in AD due to ApoE4 | 000 | 3 | NIH | 4/18/2025 | $83,932 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD036170 | Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease | 000 | 3 | NIH | 8/4/2025 | $1 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD036170 | Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease | 000 | 3 | NIH | 8/4/2025 | $472,499 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01CA276368 | Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy | 001 | 3 | NIH | 6/6/2025 | $74,919 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01CA276368 | Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy | 000 | 3 | NIH | 1/13/2025 | $674,268 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG088324 | Proteostasis, Neuroinflammation and Neurodegeneration in Frontotemporal Dementia | 000 | 1 | NIH | 5/16/2025 | $630,496 |
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