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 | Issue Date FY: 2025 ( Subtotal = $44,932,960 ) (Continued on the next page) |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG085468 | Study Alzheimer's Disease Protective APOE Variants | 000 | 2 | NIH | 11/21/2024 | $847,228 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033381 | Molecular tools to decipher communication across the blood-brain barrier | 001 | 5 | NIH | 8/15/2025 | $1 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD033381 | Molecular tools to decipher communication across the blood-brain barrier | 001 | 5 | NIH | 8/15/2025 | $944,999 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS128909 | Elucidating microvascular contributions to cognitive impairment at single-cell resolution | 005 | 4 | NIH | 6/27/2025 | $1,165,270 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | UM1AI164559 | HOPE - HIV Obstruction by Programmed Epigenetics | 000 | 5 | NIH | 7/18/2025 | $4,951,244 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS121287 | Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity | 000 | 4 | NIH | 11/21/2024 | $371,162 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R21HL173710 | Targeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery Vehicles | 000 | 2 | NIH | 3/31/2025 | $283,500 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | K01HL173644 | Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations | 000 | 2 | NIH | 8/4/2025 | $179,280 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01DA059551 | Sorting and Sequencing Latent Reservoirs in HIV+ Opioid Users | 001 | 3 | NIH | 8/11/2025 | $1,557,466 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG072052 | C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | 001 | 3 | NIH | 6/10/2025 | $56,699 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG072052 | C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | 000 | 3 | NIH | 4/1/2025 | $637,876 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG085961 | Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model | 001 | 2 | NIH | 5/29/2025 | $0 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG085961 | Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model | 000 | 2 | NIH | 11/19/2024 | $76,756 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG092683 | Harnessing novel machine learning approaches for behavioral segmentation and brain signal integration in humanized models of Alzheimer's disease | 000 | 1 | NIH | 6/11/2025 | $817,357 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | K01AG083732 | Machine Learning Approaches for Behavioral Phenotyping of Humanized Knock-in Models of Alzheimer's Disease | 000 | 3 | NIH | 5/16/2025 | $150,630 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01DK131526 | Multiomics characterization, induction, and elimination of the HIV gut reservoir | 000 | 4 | NIH | 4/29/2025 | $724,238 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG082460 | Understanding how neuronal glucose metabolism changes in AD due to ApoE4 | 001 | 3 | NIH | 6/23/2025 | $1,428 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | F32AG082460 | Understanding how neuronal glucose metabolism changes in AD due to ApoE4 | 000 | 3 | NIH | 4/18/2025 | $83,932 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01CA276368 | Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy | 001 | 3 | NIH | 6/6/2025 | $74,919 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01CA276368 | Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy | 000 | 3 | NIH | 1/13/2025 | $674,268 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD036170 | Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease | 000 | 3 | NIH | 8/4/2025 | $1 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | DP5OD036170 | Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease | 000 | 3 | NIH | 8/4/2025 | $472,499 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG088324 | Proteostasis, Neuroinflammation and Neurodegeneration in Frontotemporal Dementia | 000 | 1 | NIH | 5/16/2025 | $630,496 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG092390 | Targeting Nell2 and GABAergic Dysfunction to Mitigate APOE4-Driven Pathogenesis in Alzheimer's Disease | 000 | 1 | NIH | 5/16/2025 | $804,450 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01DA063159 | Targeted small molecule recruitment to suppress the HIV transcriptionally active reservoir | 000 | 1 | NIH | 5/7/2025 | $687,416 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL160862 | Linking microbiome genetic variants with cardiovascular phenotypes in 50,000 individuals | 000 | 4 | NIH | 8/7/2025 | $685,007 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG078164 | Develop AD Connectivity Maps with Human iPSC-Derived Brain Cells and their Use | 000 | 4 | NIH | 5/22/2025 | $922,930 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R13NS143282 | American Society for Neural Therapy and Repair Annual Conference April 2025 | 000 | 1 | NIH | 4/25/2025 | $10,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R13NS143282 | American Society for Neural Therapy and Repair Annual Conference April 2025 | 001 | 1 | NIH | 5/30/2025 | $10,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R13NS143282 | American Society for Neural Therapy and Repair Annual Conference April 2025 | 001 | 1 | NIH | 5/30/2025 | -$10,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R61AG094667 | Enhancer-AAVs to monitor and restore cell-type selective inhibitory deficits and circuit dysfunction in humanized Alzheimer's disease models | 000 | 1 | NIH | 7/29/2025 | $1,459,072 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | P01AG073082 | Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease | 001 | 5 | NIH | 8/27/2025 | $0 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | P01AG073082 | Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease | 000 | 5 | NIH | 8/5/2025 | $4,564,091 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL114948 | Early cardiac progenitors | 001 | 13 | NIH | 7/30/2025 | $777,297 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01ES036325 | Investigating Novel Genetic Variants that Confer Susceptibility to Pesticide-induced Parkinson's Disease | 000 | 1 | NIH | 1/17/2025 | $728,408 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01LM013617 | Image Tools for Computational Cellular Barcoding and Automated Annotation | 001 | 4 | NIH | 6/6/2025 | $39,834 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01LM013617 | Image Tools for Computational Cellular Barcoding and Automated Annotation | 000 | 4 | NIH | 12/20/2024 | $358,515 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG087323 | Exploring NOX2-Mediated Network Impairment and Neurodegeneration in Alzheimer's Disease | 000 | 1 | NIH | 12/5/2024 | $842,175 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01AG071697 | Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease | 001 | 5 | NIH | 9/4/2025 | $65,386 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R00HD110319 | Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health | 001 | 3 | NIH | 8/21/2025 | $747,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R00HD110319 | Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health | 001 | 3 | NIH | 8/21/2025 | -$747,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R61DA065570 | Studying NeuroHIV and addictive substances in a human microglia-neuron chimera mouse model | 000 | 1 | NIH | 8/15/2025 | $1,088,600 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R00HD110319 | Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health | 000 | 3 | NIH | 8/7/2025 | $747,000 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R35NS143067 | Neurovascular Interactions: Mechanisms, Imaging, Therapeutics | 000 | 1 | NIH | 8/14/2025 | $1,375,478 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL175312 | Epigenomic mechanisms of cardiac fibrosis and heart failure | 000 | 1 | NIH | 9/12/2025 | $811,885 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL181372 | Chromatin Regulation of Immune Cells in Myocardial Inflammation | 000 | 1 | NIH | 9/12/2025 | $803,768 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01NS124848 | Dissecting the Etiology of The Lewy Body Dementias | 000 | 2 | NIH | 8/15/2025 | $764,836 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R01HL179702 | Mechanisms of Oxygen Toxicity | 000 | 1 | NIH | 8/19/2025 | $731,827 |
| | 2025 | 2025 | J.DAVID GLADSTONE INSTITUTES | 1650 OWENS ST | SAN FRANCISCO | CA | 94158-2261 | SAN FRANCISCO | USA | R33NS133257 | OPC-X screen: Discovery of small molecule inhibitors to overcome extrinsic inhibition of remyelination. | 000 | 2 | NIH | 8/18/2025 | $472,500 |
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