Wednesday, January 15, 2025 1/15/2025

BindingDB: Data and Tools for Drug Discovery, Chemical Biology and Systems Pharmacology

Award Number: R01GM070064
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Most medications are small organic molecules which work by binding disease-related proteins. As biomedical research yields ideas for additional proteins which could be targeted by new drugs, thousands of small molecules are synthesized and tested, in both industry and academia, for their ability to bind these targeted proteins. Chemical biologists also develop small molecules targeted to specific proteins in order to elucidate pathways and cellular mechanisms. The resulting flow of protein-ligand interaction data have many uses well beyond the specific projects which generated them, such as testing and improve computational drug design technologies, and generating hypotheses for the mechanisms of action of bioactive compounds. However, they are published almost exclusively in scientific articles and patents, where they cannot be readily and systematically searched, browsed, and retrieved. BindingDB, the first open database to collect these protein- small molecule binding data and make them available for query, download, and analysis, provides users worldwide with ready access to a growing data collection, currently 1.2 million data for 500K small molecules and thousands of proteins. In the forthcoming grant period, we plan to continue the core activity of expanding BindingDB’s data collection by harvesting relevant data from other on-line resources and continuing in-house curation of data from new scientific articles and patents. We will also carry out major upgrades of the BindingDB web-site, providing a less cluttered look and new features, such as ones to refine search results, gain overviews of the large BindingDB data collection, and customize the content of data downloads requested by users. New capabilities will also be developed to support applications in the emerging field of systems pharmacology, by annotating the proteins in biomolecular networks and pathways with small molecule binding data from BindingDB and constructing tools to qualitatively model the effects of perturbing pathways with small molecule binders. Finally, we will share information about BindingDB through a variety of channels, and will work with education experts to develop and disseminate instructional applications of BindingDB.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	16	7/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	16	2/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $367,203 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	16	2/28/2020	NON-COMPETING CONTINUATION	$36,721
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	16	12/30/2019	NON-COMPETING CONTINUATION	$330,482
														Subtotal = $367,203

Issue Date FY: 2019 ( Subtotal = $367,203 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	15	12/14/2018	NON-COMPETING CONTINUATION	$367,203
														Subtotal = $367,203

Issue Date FY: 2018 ( Subtotal = $368,381 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	14	5/7/2018	NON-COMPETING CONTINUATION	$36,839
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	14	12/6/2017	NON-COMPETING CONTINUATION	$331,542
														Subtotal = $368,381

Issue Date FY: 2017 ( Subtotal = $378,983 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	13	12/19/2016	COMPETING CONTINUATION	$378,983
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	003	13	5/25/2017	COMPETING CONTINUATION	$50,978
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	12	5/25/2017	EXTENSION WITH OR WITHOUT FUNDS	-$50,978
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	12	12/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $378,983

Issue Date FY: 2016 ( Subtotal = $513,070 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	12	12/17/2015	EXTENSION WITH OR WITHOUT FUNDS	$461,763
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	12	2/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$51,307
														Subtotal = $513,070

Issue Date FY: 2015 ( Subtotal = $514,707 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	11	12/16/2014	NON-COMPETING CONTINUATION	$463,236
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	11	2/2/2015	NON-COMPETING CONTINUATION	$51,471
														Subtotal = $514,707

Issue Date FY: 2014 ( Subtotal = $513,070 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	10	2/28/2014	NON-COMPETING CONTINUATION	$51,306
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	10	1/30/2014	NON-COMPETING CONTINUATION	$461,764
														Subtotal = $513,070

Issue Date FY: 2013 ( Subtotal = $274,849 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	9	2/7/2013	COMPETING CONTINUATION	$274,849
2013	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	8	2/6/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $274,849

Issue Date FY: 2012 ( Subtotal = $499,812 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	8	1/9/2012	NON-COMPETING CONTINUATION	$452,690
2012	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	8	5/17/2012	NON-COMPETING CONTINUATION	$47,122
														Subtotal = $499,812

Issue Date FY: 2011 ( Subtotal = $499,812 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	000	7	1/18/2011	NON-COMPETING CONTINUATION	$468,007
2011	2011	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	7	8/1/2011	NON-COMPETING CONTINUATION	$31,805
														Subtotal = $499,812

Issue Date FY: 2010 ( Subtotal = $462,440 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	002	6	7/15/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$47,591
2010	2010	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Biomedical Research and Research Training	001	6	5/27/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$510,031
2010	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	5	5/21/2010	COMPETING CONTINUATION	$0
														Subtotal = $462,440

Issue Date FY: 2009 ( Subtotal = $519,566 )
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	5	12/18/2008	COMPETING CONTINUATION	$519,566
2009	2007	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	4	12/18/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $519,566

Issue Date FY: 2007 ( Subtotal = $398,181 )
2007	2007	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	4	1/16/2007	NON-COMPETING CONTINUATION	$398,181
														Subtotal = $398,181

Issue Date FY: 2006 ( Subtotal = $412,757 )
2006	2006	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	3	2/10/2006	NON-COMPETING CONTINUATION	$412,757
														Subtotal = $412,757

Issue Date FY: 2005 ( Subtotal = $395,224 )
2005	2005	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	2	1/28/2005	NON-COMPETING CONTINUATION	$395,224
														Subtotal = $395,224

Issue Date FY: 2004 ( Subtotal = $400,475 )
2004	2004	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	1	1/23/2004	NEW	$400,475
														Subtotal = $400,475

Grand Total All Awards = $6,885,733

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BindingDB: Data and Tools for Drug Discovery, Chemical Biology and Systems Pharmacology

Award Number: R01GM070064

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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