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Protein Interactions that Regulate Cell Polarity

Award Number: R01GM068032
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): The long-term objective of this work is to understand the molecular basis by which cells are polarized. Polarity is a fundamental property of cells that is required for proper development as well as adult physiology. For example, during development cell fate determinants are polarized in dividing cells as a mechanism for generating cell type diversity and the loss of cell polarity is a hallmark of many disease states, including cancer. For spatially and temporally precise establishment of cell polarity to occur, cellular signals must be interpreted and ultimately coupled to the segregation of the relevant cellular components. In diverse cell types, polarity is controlled by the evolutionarily conserved Par complex consisting of Bazooka (Baz; aka Par-3), Par-6, and atypical Protein Kinase C (aPKC). It has recently become clear that aPKC activity is the primary output of the Par complex. In this grant we seek to answer three fundamental aspects of aPKC-how it is targeted to specific cellular sites, how its activity is regulated, and how phosphorylation of substrates regulate their localization. Understanding the molecular events that lead to the coupled recruitment and activation of the Par complex will yield new insight into cell polarity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$17,321 )
2022	2016	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	13	10/1/2021	NON-COMPETING CONTINUATION	-$17,321
														Subtotal = -$17,321

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	13	2/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	003	12	2/24/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$17,321
2017	2014	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	002	11	2/24/2017	NON-COMPETING CONTINUATION	-$17,321
2017	2013	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	10	2/23/2017	COMPETING CONTINUATION	$17,321
2017	2012	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	9	2/23/2017	NON-COMPETING CONTINUATION	-$17,321
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $310,538 )
2016	2016	UNIVERSITY OF OREGON	POST OFFICE BOX 3237	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	13	8/18/2016	NON-COMPETING CONTINUATION	$310,538
														Subtotal = $310,538

Issue Date FY: 2015 ( Subtotal = $310,538 )
2015	2015	UNIVERSITY OF OREGON	POST OFFICE BOX 3237	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	12	8/25/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$310,538
														Subtotal = $310,538

Issue Date FY: 2014 ( Subtotal = $310,538 )
2014	2014	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	11	8/27/2014	NON-COMPETING CONTINUATION	$310,538
														Subtotal = $310,538

Issue Date FY: 2013 ( Subtotal = $310,538 )
2013	2013	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	10	9/18/2013	COMPETING CONTINUATION	$310,538
2013	2012	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	9	9/13/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $310,538

Issue Date FY: 2012 ( Subtotal = $304,871 )
2012	2012	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	9	3/26/2012	NON-COMPETING CONTINUATION	$30,487
2012	2012	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	9	12/2/2011	NON-COMPETING CONTINUATION	$274,384
														Subtotal = $304,871

Issue Date FY: 2011 ( Subtotal = $305,866 )
2011	2011	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	8	6/16/2011	NON-COMPETING CONTINUATION	$27,806
2011	2011	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	8	12/22/2010	NON-COMPETING CONTINUATION	$278,060
														Subtotal = $305,866

Issue Date FY: 2010 ( Subtotal = $309,896 )
2010	2010	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	7	3/4/2010	NON-COMPETING CONTINUATION	$28,173
2010	2010	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	7	12/10/2009	NON-COMPETING CONTINUATION	$281,723
														Subtotal = $309,896

Issue Date FY: 2009 ( Subtotal = $313,915 )
2009	2009	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	002	6	11/24/2008	COMPETING CONTINUATION	$313,915
2009	2008	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	5	11/24/2008	SUPPLEMENT FOR EXPANSION	$0
2009	2007	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	5	11/24/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $313,915

Issue Date FY: 2008 ( Subtotal = $114,065 )
2008	2008	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	5	4/21/2008	SUPPLEMENT FOR EXPANSION	$114,065
														Subtotal = $114,065

Issue Date FY: 2007 ( Subtotal = $344,180 )
2007	2007	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	5	5/1/2007	NON-COMPETING CONTINUATION	$344,180
														Subtotal = $344,180

Issue Date FY: 2006 ( Subtotal = $351,974 )
2006	2006	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	4	5/1/2006	NON-COMPETING CONTINUATION	$351,974
														Subtotal = $351,974

Issue Date FY: 2005 ( Subtotal = $333,668 )
2005	2005	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	3	8/22/2005	SUPPLEMENT FOR EXPANSION	$72,918
2005	2005	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	3	4/22/2005	NON-COMPETING CONTINUATION	$260,750
														Subtotal = $333,668

Issue Date FY: 2004 ( Subtotal = $260,750 )
2004	2004	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	2	4/29/2004	NON-COMPETING CONTINUATION	$260,750
														Subtotal = $260,750

Issue Date FY: 2003 ( Subtotal = $260,750 )
2003	2003	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	1		NEW	$260,750
														Subtotal = $260,750

Grand Total All Awards = $4,124,766

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Protein Interactions that Regulate Cell Polarity

Award Number: R01GM068032

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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