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CAGED PROBES FOR CELLULAR PHYSIOLOGY

Award Number: R01GM056481
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1998
PERIOD OF PERFORMANCE END DATE: 01/02/2010

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CAGED PROBES FOR CELLULAR PHYSIOLOGY - DESCRIPTION (provided by applicant): A "caged" molecule is a photosensitive, but temporarily inert, precursor of a biologically active molecule. Light absorption transforms the precursor into a molecule with full bioactivity. Because a light beam can be easily focused and steered, and photochemical reactions are extremely fast, caged molecules are versatile tools for using light to manipulate biology with exceptionally high spatial and temporal resolution. The long-term objective is to develop a broad spectrum of novel photochemical tools that will enable cellular physiologists to use light to probe and control dynamic signaling processes in living cells and tissues. The proposed research has four foci: 1) Develop new "cages" that a) are strongly activated by light, b) show fast kinetics of product release on photolysis, c) give high yield of product when photolyzed, and d) are chemically and metabolically stable in the absence of light. 2) Develop new probes for cellular signaling, specifically cage neurotransmitters, lipid messengers, as well as probes that permit "photochemical knock-out" of neurotransmitter receptors and transporters, and ion channels. 3) Develop and optimize two probes of intracellular calcium signaling: a caged calcium and a caged "anti- calcium" for using light to rapidly generate and ablate intracellular calcium signals, respectively. 4) Apply the developed probes to cellular physiology research in the areas of signal processing by nerve terminals and dendrites, synaptic plasticity, and calcium regulation of cell excitability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $349,806 )
2010	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	12	5/12/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$349,806
2010	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	11	5/12/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $349,806

Issue Date FY: 2009 ( Subtotal = $395,223 )
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	002	11	3/31/2009	NON-COMPETING CONTINUATION	$38,160
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	11	3/10/2009	NON-COMPETING CONTINUATION	$343,438
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	10	2/18/2009	SUPPLEMENT FOR EXPANSION	$13,625
														Subtotal = $395,223

Issue Date FY: 2008 ( Subtotal = $349,807 )
2008	2008	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	10	3/5/2008	NON-COMPETING CONTINUATION	$349,807
														Subtotal = $349,807

Issue Date FY: 2007 ( Subtotal = $349,807 )
2007	2007	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	9	2/27/2007	COMPETING CONTINUATION	$349,807
														Subtotal = $349,807

Issue Date FY: 2006 ( Subtotal = $94,050 )
2006	2006	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	8	7/17/2006	SUPPLEMENT FOR EXPANSION	$94,050
														Subtotal = $94,050

Issue Date FY: 2005 ( Subtotal = $336,400 )
2005	2005	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	8	6/27/2005	NON-COMPETING CONTINUATION	$336,400
														Subtotal = $336,400

Issue Date FY: 2004 ( Subtotal = $350,460 )
2004	2004	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	7	7/5/2004	NON-COMPETING CONTINUATION	$350,460
														Subtotal = $350,460

Issue Date FY: 2003 ( Subtotal = $346,110 )
2003	2003	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	001	6	9/1/2003	SUPPLEMENT FOR EXPANSION	$63,960
2003	2003	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	000	6	7/2/2003	NON-COMPETING CONTINUATION	$282,150
														Subtotal = $346,110

Issue Date FY: 2002 ( Subtotal = $295,260 )
2002	2002	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	000	5	6/24/2002	COMPETING CONTINUATION	$295,260
														Subtotal = $295,260

Issue Date FY: 2001 ( Subtotal = $230,735 )
2001	2001	MARYLAND BIOTECHNOLOGY INSTITUTE	4321 HARTWICK ROAD	COLLEGE PARK	MD			USA	Cell Biology and Biophysics Research	000	4	3/23/2001	NON-COMPETING CONTINUATION	$230,735
														Subtotal = $230,735

Issue Date FY: 2000 ( Subtotal = $224,101 )
2000	2000	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	000	3	3/16/2000	NON-COMPETING CONTINUATION	$224,101
														Subtotal = $224,101

Issue Date FY: 1999 ( Subtotal = $217,844 )
1999	1999	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	000	2	3/26/1999	NON-COMPETING CONTINUATION	$217,844
														Subtotal = $217,844

Issue Date FY: 1998 ( Subtotal = $232,149 )
1998	1998	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Cell Biology and Biophysics Research	000	1	3/5/1998	NEW	$232,149
														Subtotal = $232,149

Grand Total All Awards = $3,771,752

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CAGED PROBES FOR CELLULAR PHYSIOLOGY

Award Number: R01GM056481

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1998

PERIOD OF PERFORMANCE END DATE: 01/02/2010

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