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STRUCTURE, FUNCTION AND STABILITY OF T4 PHAGE LYSOZYME

Award Number: R01GM021967
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/1978
PERIOD OF PERFORMANCE END DATE: 03/31/2009

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STRUCTURE, FUNCTION AND STABILITY OF T4 PHAGE LYSOZYME - DESCRIPTION (provided by applicant): The principal objective of this proposal is to use T4 lysozyme as a model system to better understand the factors that determine the folding, stability, structure and function of proteins. The specific research to be accomplished includes the following: (1) The body of structural, thermodynamic, and kinetic information on mutant T4 lysozymes will be used, both within the group and in collaboration with others, to test and improve computer-assisted protein design. (2) An attempt will be made to simplify the protein folding problem by identifying which residues, or combination of residues, are critical for the folding and stability of T4 lysozyme. We want to understand, not only how given residues contribute to stability, but also the relative importance of local versus non-local effects in protein folding. (3) Cavities within T4 lysozyme will be exploited to better understand protein-ligand interaction and to optimize rational approaches to drug selection and docking (in collaboration with B. Shoichet). (4) We will attempt to engineer a long-distance, ligand-induced conformational switch in a protein. (5) Neutron crystallography will be used to characterize catalytic intermediates and to compare dynamical processes in crystals of T4 lysozyme with those in solution. (6) The contribution of solvent to protein folding and stability will be further analyzed. (7) The effects of pressure on proteins with cavities will be determined.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $352,012 )
2008	2008	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	33	3/28/2008	NON-COMPETING CONTINUATION	$352,012
														Subtotal = $352,012

Issue Date FY: 2007 ( Subtotal = $352,012 )
2007	2007	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	32	3/28/2007	NON-COMPETING CONTINUATION	$352,012
														Subtotal = $352,012

Issue Date FY: 2006 ( Subtotal = $362,526 )
2006	2006	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	31	3/30/2006	NON-COMPETING CONTINUATION	$362,526
														Subtotal = $362,526

Issue Date FY: 2005 ( Subtotal = $371,563 )
2005	2005	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	30	4/1/2005	COMPETING CONTINUATION	$371,563
														Subtotal = $371,563

Issue Date FY: 2003 ( Subtotal = $363,902 )
2003	2003	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	29		NON-COMPETING CONTINUATION	$363,902
														Subtotal = $363,902

Issue Date FY: 2002 ( Subtotal = $364,137 )
2002	2002	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	28	3/25/2002	NON-COMPETING CONTINUATION	$364,137
														Subtotal = $364,137

Issue Date FY: 2001 ( Subtotal = $364,357 )
2001	2001	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	27	3/14/2001	NON-COMPETING CONTINUATION	$364,357
														Subtotal = $364,357

Issue Date FY: 2000 ( Subtotal = $364,563 )
2000	2000	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	26	3/17/2000	COMPETING CONTINUATION	$364,563
														Subtotal = $364,563

Issue Date FY: 1999 ( Subtotal = $329,882 )
1999	1999	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	25	3/22/1999	NON-COMPETING CONTINUATION	$329,882
														Subtotal = $329,882

Issue Date FY: 1998 ( Subtotal = $317,310 )
1998	1998	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Cell Biology and Biophysics Research	000	24	3/23/1998	NON-COMPETING CONTINUATION	$317,310
														Subtotal = $317,310

Grand Total All Awards = $3,542,264

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STRUCTURE, FUNCTION AND STABILITY OF T4 PHAGE LYSOZYME

Award Number: R01GM021967

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/1978

PERIOD OF PERFORMANCE END DATE: 03/31/2009

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