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Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal

Award Number: R01EY012549
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/03/1999
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal - PROJECT SUMMARY This proposal is a renewal application for R01 EY012549 entitled Cell-Cell Signaling in Embryonic and Retinal Development . The question of how complex tissues like the eye achieve the cellular organization and three-dimensional form required for vision is of fundamental importance to understanding both normal developmental progression and disease mechanisms that perturb cell shapes, structures and patterns. A great deal is known about the genetically controlled terminal differentiation programs that produce the specialized cytoskeletal structures, cell-cell junctional adhesions and cell-extracellular matrix contacts unique to each retinal cell type. How the resulting cell shapes, structures and connections introduce physical constraints that influence final organ shape and function is not well-studied. This is particularly critical to a complex organ like the eye, because the organization of its diverse and highly specialized cell types must be precise to support vision. The goal of this proposal is to understand the cellular and tissue-scale properties and interactions that together sculpt the final form of the Drosophila compound eye. The fly retina provides a superbly tractable and well- defined experimental model, with a proven track record in uncovering conserved mechanisms. The stereotyped patterning and architecture of the fly retina facilitates the identification and tracking of individual cell types over space and time, and the wealth of available markers permits detailed analysis and quantification of cell shapes, structures, interactions and tissue-level patterns. Improving our understanding of fundamental morphogenetic processes has relevance not only to normal development and regenerative biology, but also to considering how disease-associated defects in one cell type or in one organ may influence adjacent cell types or organs. Thus, the knowledge gained from the studies described in this proposal will improve understanding of an important area of developmental biology and impact human health. Aim 1 will investigate how interactions between different retinal cell types elaborate and maintain the precise 3D tissue organization and structure required for vision. Our hypothesis is that cell-cell and cell-ecm interactions provide redundant mechanical coupling that organizes pattern, drives cellular differentiation and ensures robustness of the retinal morphogenetic program. Aim 2 will explore how tissue-intrinsic properties and the retinal-extrinsic environment contribute to the establishment and maintenance of retinal curvature, a tissue-level property critical for vision. We hypothesize that the pupal retina transitions from an initial “floppy” or viscous-like state that can be influenced by its physical environment to a rigid or elastic solid-like state that can autonomously support tissue shape.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $478,870 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	20	2/14/2025	NON-COMPETING CONTINUATION	$478,870
														Subtotal = $478,870

Issue Date FY: 2024 ( Subtotal = $478,870 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	19	1/17/2024	COMPETING CONTINUATION	$478,870
														Subtotal = $478,870

Issue Date FY: 2023 ( Subtotal = -$35,311 )
2023	2019	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	18	5/15/2023	NON-COMPETING CONTINUATION	-$35,311
														Subtotal = -$35,311

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	18	1/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	18	6/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $344,364 )
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	18	6/13/2019	NON-COMPETING CONTINUATION	$344,364
														Subtotal = $344,364

Issue Date FY: 2018 ( Subtotal = $379,675 )
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	17	9/10/2018	NON-COMPETING CONTINUATION	$379,675
														Subtotal = $379,675

Issue Date FY: 2017 ( Subtotal = $401,387 )
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Vision Research	000	16	6/27/2017	NON-COMPETING CONTINUATION	$401,387
														Subtotal = $401,387

Issue Date FY: 2016 ( Subtotal = $436,698 )
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	14	12/14/2015	SUPPLEMENT FOR EXPANSION	$35,311
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	002	15	6/16/2016	NON-COMPETING CONTINUATION	$401,387
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	001	14	12/22/2015	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $436,698

Issue Date FY: 2015 ( Subtotal = $344,364 )
2015	2015	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	14	6/11/2015	COMPETING CONTINUATION	$344,364
														Subtotal = $344,364

Issue Date FY: 2011 ( Subtotal = $358,917 )
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	13	8/25/2011	NON-COMPETING CONTINUATION	$358,917
														Subtotal = $358,917

Issue Date FY: 2010 ( Subtotal = $370,133 )
2010	2010	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	001	12	8/26/2010	NON-COMPETING CONTINUATION	$370,133
2010	2007	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	10	4/22/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $370,133

Issue Date FY: 2009 ( Subtotal = $373,872 )
2009	2009	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	002	11	8/27/2009	COMPETING CONTINUATION	$373,872
2009	2007	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	10	4/20/2009	NON-COMPETING CONTINUATION	$0
2009	2007	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	001	10	8/27/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $373,872

Issue Date FY: 2007 ( Subtotal = $370,206 )
2007	2007	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	10	5/30/2007	NON-COMPETING CONTINUATION	$370,206
														Subtotal = $370,206

Issue Date FY: 2006 ( Subtotal = $374,732 )
2006	2006	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Vision Research	000	9	6/21/2006	NON-COMPETING CONTINUATION	$374,732
														Subtotal = $374,732

Issue Date FY: 2005 ( Subtotal = $471,850 )
2005	2005	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	7	9/26/2005	NON-COMPETING CONTINUATION	$471,850
														Subtotal = $471,850

Issue Date FY: 2004 ( Subtotal = $461,500 )
2004	2004	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	6	4/12/2004	COMPETING CONTINUATION	$461,500
														Subtotal = $461,500

Issue Date FY: 2003 ( Subtotal = $359,156 )
2003	2003	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	5	6/19/2003	NON-COMPETING CONTINUATION	$318,876
2003	2003	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	001	5	9/1/2003	SUPPLEMENT FOR EXPANSION	$40,280
														Subtotal = $359,156

Issue Date FY: 2002 ( Subtotal = $313,308 )
2002	2002	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	4	5/17/2002	NON-COMPETING CONTINUATION	$313,308
														Subtotal = $313,308

Issue Date FY: 2001 ( Subtotal = $300,578 )
2001	2001	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	3	5/2/2001	NON-COMPETING CONTINUATION	$300,578
														Subtotal = $300,578

Issue Date FY: 2000 ( Subtotal = $295,494 )
2000	2000	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	2	5/1/2000	NON-COMPETING CONTINUATION	$295,494
														Subtotal = $295,494

Issue Date FY: 1999 ( Subtotal = $271,021 )
1999	1999	WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH	9 CAMBRIDGE CENTER	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	1	5/3/1999	NEW	$271,021
														Subtotal = $271,021

Grand Total All Awards = $7,149,684

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Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal

Award Number: R01EY012549

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/03/1999

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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