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Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits

Award Number: R01ES036042
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/20/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits - ABSTRACT Human complex traits are jointly influenced by genetic and environmental risk factors, whose exact contributions are often subject to extensive debate. Detailed environmental risk factors are not often available, which makes it hard to jointly assess the genetic and environmental contributions. Yet, the emergence of large- scale national biobanks as well international genetic studies offers a great opportunity to make up for this knowledge gap. In particular, as study participants come from diverse locations, geospatial information of the study participants can be used as a proxy for environmental exposure. Models that incorporate geospatial information of study participants will lead to improved power for association analysis and more accurate heritability estimates. In this application, we propose to develop a Spatial MIxed Linear Effect model (SMILE) for improved association analysis and heritability estimation and Spatial Meta-Analysis Regression Test (SMART) for more powerful meta-analyses of genetic association studies. We will apply them to UK Biobank, MarketScan insurance billing database, TOPMed sequence data, and various large consortia studies on smoking/drinking addictions, lipids levels, and diabetes. To achieve the proposed research aims, we assembled a strong research team with complementary expertise from statistical genetics, addiction genetics, lung function genetics, biomedical informatics, and environmental epidemiology. Methods and tools developed from this study will open up new avenues for analyzing national biobanks such as UK Biobank and All of Us cohorts, and global consortium studies. The results from this study will help elucidate the genetic architecture of complex traits with significant


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $600,457 )
2026	2026	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	000	4	4/1/2026	NON-COMPETING CONTINUATION	$600,457
														Subtotal = $600,457

Issue Date FY: 2025 ( Subtotal = $600,457 )
2025	2025	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	000	3	3/27/2025	NON-COMPETING CONTINUATION	$600,457
2025	2025	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	001	3	9/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $600,457

Issue Date FY: 2024 ( Subtotal = $623,106 )
2024	2024	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	001	2	3/29/2024	NON-COMPETING CONTINUATION	$623,106
2024	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	000	1	1/15/2024	NEW	$0
														Subtotal = $623,106

Issue Date FY: 2023 ( Subtotal = $288,010 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Environmental Health	000	1	6/16/2023	NEW	$288,010
														Subtotal = $288,010

Grand Total All Awards = $2,112,030

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Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits

Award Number: R01ES036042

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/20/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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