Thursday, November 21, 2024 11/21/2024

Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging

Award Number: R01ES033054
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The diversity supplement submission aims to fund Ms. Kelli Williams' participation in an environmental epidemiology study to gain knowledge about the design, conduct, and analysis of epidemiological research for environmental toxins in children, and to contribute her expertise in the social determinants of health combined with her enthusiasm for increasing diversity in research to the overall process by developing and conducting an ancillary study. Ms. Williams is currently enrolled in the Epidemiology PhD program at the University of Pennsylvania and is not funded by any other NIH grant. Some environmental chemicals of concern to children are polybrominated diphenyl ethers (PBDEs) and organophosphate esters (OPEs). PBDEs hyperactivity, shown particulates affects and of neurodevelopment ongoing prospective PBDEs assess modification health retardant using Holmes, minority are linked to memory issues, and cognitive impairment, disrupting vital t hyroid ormones. OPEs have been to have neurotoxicity and behavioral effects in animals and some human studies. Children exposed t o experience sleep disturbances, and sleep is crucial for proper neurodevelopment; its deficiency cognition, psychosocial development, and mental health. Research gaps exist regarding how prenatal postnatal PBDEs/OPEs influence U.S child sleep health and neurodevelopment with social determinants health (SDOH) considerations. No prior studies explore these chemicals' roles in sleep health-mediated and their SDOH interactions. Filling this gap demands epidemiological studies through an birth cohort assessing environmental toxicants ffects on human neurobehaviors. Through a pregnancy and birth cohort study, we will: 1) investigate the associations between pre/post-natal and sleep health; 2) investigate the associations between pre-/post-natal OPEs and sleep health; 3) the mediation effect of sleep health and PBDEs/OPEs on neurobehavior; and 4) determine the effect of specific SDOH between PBDEs/OPEs and sleep health and neurobehavior. Ms. Williams has an immense interest and background in population-research, social determinants of research. She will design and complete her doctoral issertation assessing the impact of prenatal flame- exposure on sleep health, neurodevelopment, and social determinants of health factors in children, innovative analysis techniques, under the guidance of her mentors, Dr. Aimin Chen and Dr. John with a goal of an independently unded research career to improve various disease outcomes for and/or underserved populations. h e d f


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	000	4	10/16/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $734,254 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	002	4	5/3/2024	NON-COMPETING CONTINUATION	$619,410
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	001	3	5/2/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	004	3	8/13/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	000	3	2/6/2024	SUPPLEMENT FOR EXPANSION	$26,365
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	003	4	5/6/2024	SUPPLEMENT FOR EXPANSION	$88,479
														Subtotal = $734,254

Issue Date FY: 2023 ( Subtotal = $624,770 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	000	3	5/12/2023	NON-COMPETING CONTINUATION	$624,770
														Subtotal = $624,770

Issue Date FY: 2022 ( Subtotal = $646,115 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	000	2	5/10/2022	NON-COMPETING CONTINUATION	$646,115
														Subtotal = $646,115

Issue Date FY: 2021 ( Subtotal = $683,695 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Environmental Health	000	1	6/30/2021	NEW	$683,695
														Subtotal = $683,695

Grand Total All Awards = $2,688,834

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Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging

Award Number: R01ES033054

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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